Effect of organic and inorganic acids on concentrated chitosan solutions and gels

Hamdine, Mélina; Heuzey, Marie‐Claude; Bégin, André

doi:10.1016/j.ijbiomac.2005.09.009

Cited by 93 publications

(51 citation statements)

References 23 publications

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“…Scaffolds were obtained only with 0.5 wt.% of gelatin since higher concentrations lowered mechanical resistance and formed higher volumes of foam that prevented cement's setting. Furthermore, chitosan addition was necessary in order to maintain the foam stability by gelling CPC liquid phase and avoiding the collapse of the porous structure during cement setting 9,10 . Samples without gelatin (B and BC) exhibited lower porosity than those containing gelatin (BC0.5G, BC1G, BC0.5Gf).…”

Section: Resultsmentioning

confidence: 99%

“…Gelatin was employed as a foaming agent and chitosan was added to stabilize the foam 9,10,14 . All formulations are described in Table 1.…”

Section: Calcium Phosphate Cement (Cpc) and Scaffoldsmentioning

confidence: 99%

“…Foam stability was obtained by increasing wt.% of gelatin. A different path to obtain foam stability is to employ chitosan 7,9,10 , a biopolymer originated from chitin; that is non-toxic, biodegradable, and biocompatible. It is insoluble in water or in body fluid, but soluble below pH 6.5 in most of the acidic mediums.…”

Section: Introductionmentioning

confidence: 99%

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Scaffolds of calcium phosphate cement containing chitosan and gelatin

et al. 2013

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Calcium phosphate cements (CPCs) have potential to be used on repairing damaged bones due to their moldability, bioactivity and bioresorbability. These materials combine calcium orthophosphate powders with a liquid leading to a paste that hardens spontaneously at low temperatures. Hence, CPCs could be applied as scaffolds to support cell/tissue growth. This paper studies CPC scaffolds processing by foaming cement's liquid phase in which was added gelatin and chitosan. The former acted to increase the foam stability while the ladder acted as a foaming agent. Moreover, these polymers would enhance scaffold's biological properties by controlling material's total porosity and in vivo resorption. The method proposed led to scaffolds with 58.71% porosity with sizes ranging from 160 to 760 µm and compressive strength of 0.70MPa. After foaming, pores' size, distribution and interconnectivity changed significantly leading to a material that could be applied on bone regeneration since it would allow nutrient's transport, cell attachment and an increase in material degradation rate.

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Section: Resultsmentioning

confidence: 99%

“…Gelatin was employed as a foaming agent and chitosan was added to stabilize the foam 9,10,14 . All formulations are described in Table 1.…”

Section: Calcium Phosphate Cement (Cpc) and Scaffoldsmentioning

confidence: 99%

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Scaffolds of calcium phosphate cement containing chitosan and gelatin

et al. 2013

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“…The biocompatibility, non-toxicity and antibacterial activity is excellent properties for development of new biomaterials, on the other hand, shows a strong resource sustainability, originating from biomass, or to be in the food industry, which further reinforce potential and the applicability of these polymers in health area [15].…”

Section: Introductionmentioning

confidence: 99%

“…Changes in chemical and biological properties depend on the nature of the side group. Furthermore, the characteristics of chitosan, such as cationic, hemostatic and insoluble at high pH, can be completely reversed, which can make the anionic watersoluble molecule and also presenting anticoagulants properties [15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Structure and Properties of Nanocrystalline Chitosan

Pighinelli

et al. 2016

JABB

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Chitosan and its derivatives are polymers with excellent properties to be used in regenerative medicine because they guarantee efficiency in the healing process. This polymer has a great potential for the development of a new generation of biomaterials that can be used in regenerative medicine and tissue engineering. The nanocrystalline chitosan (nCh) is a modified form of chitosan prepared by the method of obtaining chitosan salts. It is characterized by having the same special properties of the precursor chitosan as biocompatibility, bioactivity, be non-toxic and biodegradable. The aim of this study was to develop a new method of obtaining nanocrystalline chitosan according to their chemical and physical characterization. The material was characterized by Absorption Spectroscopy in the Infrared Region -with the Fourier transform (FTIR-ATR), scanning electron microscopy, SEM, Nuclear Magnetic Resonance, NMR, Diffraction of X-rays, particle size analysis and the potential Zeta. The results indicated that the process of obtaining nanocrystalline chitosan did not change the structure of the precursor chitosan. The analysis in the FTIR showed the same functional groups of the precursor chitosan. The 1H-NMR spectroscopy was helpful in the analysis of the chitosan samples in a wide range of values to determine the degree of deacetylation (GD). The morphology indicates the homogeneity of the structure and the surface. The X-ray diffraction shows the reduction of crystallinity of QNC, which corresponds to the amorphous structure thereof. The value of the zeta potential of the chitosan acetate (AQ) in acid media (pH 4.43) was 43.6 mV, while the value of QNC (pH 7.3) was 15.4 mV due to its high polydispersity. The variation in particle size of samples and AQ using QNC 0.450 uM mesh filter, indicated the average particle size of 55.52 and 266.0 nm, respectively.

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Synergistic antibacterial and anticancer activity in gadolinium–chitosan nanocomposite films: A novel approach for biomedical applications

Khalil,

Bashal,

Habeeb

et al. 2024

Applied Organom Chemis

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Driven by the continuous search for materials with antibacterial and anticancer applications, this study focuses on the fabrication of nanocomposite films using chitosan as the basis material, with the addition of gadolinium oxide nanoparticles at varying weight percentages (5 and 10 wt.% Gd2O3/CS). The films were made using the coprecipitation‐solution cast approach. The structural characteristics of the Gd2O3/CS films that were formed were investigated and confirmed using a range of analytical techniques, including Fourier transform infrared, X‐ray diffraction, and scanning electron microscopy–energy‐dispersive X‐ray spectroscopy. The X‐ray diffraction study provided unambiguous evidence of an increased degree of crystallinity in chitosan with the inclusion of gadolinia. The particle size was determined using the Debye–Scherrer formula, resulting in an estimated value of 36 nm. Following this, a thorough examination was undertaken to evaluate the antibacterial effectiveness against one strain of Gram‐positive bacteria and two strains of Gram‐negative bacteria. Our research has revealed that the efficacy of the inspected Gd2O3/CS as bactericides is superior to that of CS alone. Furthermore, the MCF‐7, HCT‐116, and HepG‐2 cell lines exhibited anticancer activity when exposed to the Gd2O3/CS nanocomposites. In addition, nanocomposites exhibit significant antioxidant activity in comparison with the conventional vitamin C. These findings provide evidence for the viability of our nanocomposites in combating breast cancer.

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Effect of organic and inorganic acids on concentrated chitosan solutions and gels

Cited by 93 publications

References 23 publications

Scaffolds of calcium phosphate cement containing chitosan and gelatin

Scaffolds of calcium phosphate cement containing chitosan and gelatin

Structure and Properties of Nanocrystalline Chitosan

Synergistic antibacterial and anticancer activity in gadolinium–chitosan nanocomposite films: A novel approach for biomedical applications

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