Effect of orally ingested diosgenin into diet on skin collagen content in a low collagen skin mouse model and its mechanism of action

Haratake, Akinori; Watase, Daisuke; Setoguchi, Shuichi; Nagata-Akaho, Nami; Matsunaga, Kazuhisa; Takata, Jiro

doi:10.1016/j.lfs.2017.02.013

Cited by 11 publications

(7 citation statements)

References 26 publications

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“…Withaferin A, the active ingredient of Withania somnifera commonly known as ashwagandha or Indian ginseng, is also a plant steroid implicated in treatment of scleroderma [10]. Another plant steroid is diosgenin, a component of Dioscorea plant that showed improvement of skin collagen [11]. Several of these plant steroids have been implicated to possess anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor

Morsy

Patel

El-Sheikh

et al. 2019

Mediators of Inflammation

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Despite the usefulness of glucocorticoids, they may cause hazardous side effects that limit their use. Searching for compounds that are as equally efficient as glucocorticoids, but with less side effects, the current study compared plant steroids, namely, glycyrrhetinic acid, guggulsterone, boswellic acid, withaferin A, and diosgenin with the classical glucocorticoid, fluticasone. This was approached both in silico using molecular docking against glucocorticoid receptor (GR) and in vivo in two different animal models. All tested compounds interacted with GR, but only boswellic acid and withaferin A showed docking results comparable to fluticasone, as well as similar in vivo anti-inflammatory effects, by significantly decreasing serum levels of interleukin-6 and tumor necrosis factor-α in cotton pellet-induced granuloma in rats. In addition, both compounds significantly decreased the percent of change in ear weight in croton oil-induced ear edema in mice and the granuloma weight in cotton pellet-induced granuloma in rats, to levels comparable to that of fluticasone. Both boswellic acid and withaferin A had no effect on adrenal index, but only withaferin A significantly increased the thymus index. In conclusion, boswellic acid may have comparable anti-inflammatory effects to fluticasone with fewer side effects.

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Section: Introductionmentioning

confidence: 99%

Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor

Morsy

Patel

El-Sheikh

et al. 2019

Mediators of Inflammation

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“…25 It has been reported that diosgenin, which is a steroidal sapogenin, exhibited biological activities including antioxidant, anti-diabetes, anti-inflammatory, anti-cancer and antiadipogenic activities. 26 Haratake et al 27 concluded that diosgenin can improve skin collagen content by shifting the dynamics of the fibroblasts from proliferation to differentiation via cell cycle arrest. They therefore revealed a new therapeutic potential of diosgenin for human breast cancer metastasis therapy.…”

Section: Health Benefits Of Diosgeninmentioning

confidence: 99%

A Mini-review of Galactomannas and Diosgenin in Fenugreek

Shahrajabian¹,

Sun²,

Shen³

et al. 2021

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Introduction: Galactomannas are polysaccharides similar to cellulose and starch. Methods: A literature search was conducted in Medline, Scopus, PubMed and Google scholar databases. The keywords were fenugreek, health benefits, bioactive components, galactomannans, diosgenin and pharmaceutical science. Results: Fenugreek galactomannan is a heteropolysaccharide which reduces blood glucose level as normalize the surface activities inside the small intestine. They are also used in food products in order to increase the thickness of the water content. The most important health benefits of galactomanna are reduction in LDL cholesterol levels in hypercholesterolemic, blood lipids, as well as to reduce blood pressure and fibrinolysis. Diosgenin is an isospirostane derivative and the product of acids or enzymes hydrolysis process of dioscin and protodioscin. Conclusion:Diosgenin shows biological activities including antioxidant, anti-diabetes, anti-inflammatory, anti-cancer and anti-adipogenic effects.

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“…Through computational and biological comparison, few plant-derived steroidal compounds have been suggested as modulators of in ammation through interactions with GR (Dean et al, 2017; Morsy et al, 2019). Such plant-derived anti-in ammatory steroids like glycyrrhetinic acid [23], guggulsterone [24], boswellic acid [25], withaferin A [26] and diosgenin [27] have a common cyclopentanoperhydrophenanthrene steroid ring structure. Pregnanes are naturally occurring C21 steroidal compounds that have been documented with wide range of bioactivities including anti-in ammatory activity [20,[28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes in silico

Gyebi

Ogunyemi

Ibrahim

et al. 2021

Preprint

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The high morbidity and mortality rate of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection arises majorly from the Acute Respiratory Distress Syndrome and “cytokine storm” syndrome, which is sustained by an aberrant systemic inflammatory response and elevated pro-inflammatory cytokines. Thus, phytocompounds with broad-spectrum anti-inflammatory activity that target multiple SARS-CoV-2 proteins will enhance the development of effective drugs against the disease. In this study, an in-house library of 106 steriodal plant-derived pregnanes (PDPs) was docked in the active regions of human glucocorticoid receptors (hGRs) in a comparative molecular docking analysis. Based on the minimal binding energy and a comparative dexamethason binding mode analysis, a list of top twenty ranked PDPs docked in the agonist conformation of hGR, with binding energies ranging between -9.8 and -11.2 Kcal/mol, was obtained and analyzed for interactions with the human Janus kinases 1 and Interleukins-6 and SARS-CoV-2 3-chymotrypsin-like protease, Papain-like protease and RNA-dependent RNA polymerase. For each target protein, the top three ranked PDPs were selected. Eight PDPs (bregenin, hirundigenin, anhydroholantogenin, atratogenin A, atratogenin B, glaucogenin A, glaucogenin C and glaucogenin D) with high binding tendencies to the catalytic residues of multiple targets were identified. A high degree of structural stability was observed from the 100 ns molecular dynamics simulation analyses of glaucogenin C and hirundigenin complexes of hGR. The selected top-eight ranked PDPs demonstrated favourable druggable and in silico ADMET properties. Thus, the therapeutic potentials of glaucogenin C and hirundigenin can be explored for further in vitro and in vivo studies.

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Effect of orally ingested diosgenin into diet on skin collagen content in a low collagen skin mouse model and its mechanism of action

Cited by 11 publications

References 26 publications

Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor

Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor

A Mini-review of Galactomannas and Diosgenin in Fenugreek

Dual targeting of cytokine storm and viral replication in COVID-19 by plant-derived steroidal pregnanes in silico

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