Effect of Orally Administered Potentized Capsaicin and Dihydrocapsaicin in Humans: A Homeopathic Pathogenetic Trial

Abstract

Background: A homeopathic pathogenetic trial is a procedure to examine the disease-producing effect of any substance on humans. Capsaicin and dihydrocapsaicin are known as pain-producing agents. According to the homeopathic law of similars, any substance having the capacity to produce certain symptoms should also be able to treat them in return, when administered in small (potentized) dose. Methods: In a doubleblind, randomized placebo-controlled homeopathic pathogenetic trial with 22 volunteers, 15 received a combination of capsaicin and dihydrocapsaicin as a single remedy in 30c potency, while 7 received placebo. The volunteers' symptoms during 5 weeks were carefully noted as per protocol. The participants signed an informed consent, the study was approved by the ethics committee, and laboratory investigations were documented and safety measures adopted. Results: A preparation of orally administered ultra-high diluted capsaicin and dihydrocapsaicin unveiled qualitatively and quantitatively distinct symptoms, comparable with effects of the crude substance. Compared to placebo, the homeopathic preparation produced significant symptoms in healthy human volunteers. These findings can subsequently be used therapeutically. Conclusion: The administration of potentized capsaicin and dihydrocapsaicin combination produced symptoms of pain (and others) in healthy volunteers. This preparation can be applied therapeutically following a basic homeopathic principle. Further research to confirm the assumptions is warranted.

Randomized, Placebo-controlled Homeopathic Drug-proving of SARS CoV-2 nosode (BiosimCovex) in healthy volunteers

“…Since the phase 1 safety trial [4] was not placebo-controlled, we conducted this controlled HDP, which has shown many symptoms comparable to that of phase 1 (Table 2). The presumed nanomaterials [14] in homeopathic potencies have shown effects comparable with that of the source materials (SARS CoV 2 virus) in this study (Table 3), as well as in other studies such as HIV Nosode [15], Hepatitis C Nosode [16], and Capsaicin [17], drawing attention to the fact that the ultra-dilute format of the potentized medicines retains the ability to alter human physiology. Homeopathically, the primary effects of the BiosimCovex on healthy volunteers are suggestive of its therapeutic role for the conditions such as acute colds and coughs, bronchitis, COVID-19 illness, fibromyalgia, arthritis, headaches, anxiety, and sleeplessness.…”

Quantitative and Qualitative Pathogenetic Indices for Review of Data Derived from Homeopathic Pathogenetic Trials

“…HPTs of human immunodeficiency virus (HIV) nosode, 12 hepatitis C nosode, 9 capsaicin alkaloids (capsaicin and dihydrocapsaicin), 11 and hydroquinone (HQ) 10 were included in this analysis. These trials were published in peer-reviewed journals.…”

“…Symptoms that were exhibited by volunteers who dropped out from the study due to adverse events were also excluded from analysis. These additional filters were introduced by the author [9][10][11][12] to minimise the interference of psychological effects of the medicine. Additionally, the author introduced a method of qualifying each symptom by its intensity, on a scale of þ (mild), þþ (moderate), þþþ (severe) and þþþþ (very severe).…”

“…From 2010 to 2013, the author conducted four randomised controlled HPTs, in which he had been the lead researcher. [9][10][11][12] During the process of working on those HPTs, he methodically scrutinised the symptomatology and attempted to introduce a Quantitative Pathogenetic Index and a Qualitative Pathogenetic Index, as analytical tools to evaluate the data. With additional trial data, these indices could be validated and developed further.…”

The Science of the “Simile”

“…Hence, the specificity of the reported symptoms and the differences in these symptoms compared to those reported by people taking a placebo are not clear. The Similia principle was demonstrated to also work in the difficult field of human investigation when "conventional" statistics was applied to the HPT by our group [137] and others [138][139][140].…”