Effect of orally administered magnesium on postoperative pain level and trismus after surgical removal of the lower third molars: a randomized, double-blind, placebo-controlled trial

Jerković, Daniel; Tadin, Antonija; Gavić, Lidija; Vladislavić, Nada Zorica; Grgić, Nino; Macan, Darko

doi:10.1007/s00784-020-03335-z

Cited by 6 publications

(6 citation statements)

References 42 publications

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“…Oral magnesium also affects pain control. The pain attenuation effect of orally-administered magnesium was observed by Jerkovic et al [ 53 ] in patients who underwent surgical removal of their lower third molar. Patients who were administered oral magnesium before and after surgery showed lower pain intensity and degree of trismus.…”

Section: Magnesium and Perioperative Painmentioning

confidence: 93%

Magnesium and Pain

Shin

Hwan

2020

Nutrients

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In terms of antinociceptive action, the main mode of action of magnesium involves its antagonist action at the N-methyl-d-aspartate (NMDA) receptor, which prevents central sensitization and attenuates preexisting pain hypersensitivity. Given the pivotal function of NMDA receptors in pain transduction, magnesium has been investigated in a variety of pain conditions. The oral and parenteral administration of magnesium via the intravenous, intrathecal, or epidural route may alleviate pain and perioperative anesthetic and analgesic requirements. These beneficial effects of magnesium therapy have also been reported in patients with neuropathic pain, such as malignancy-related neurologic symptoms, diabetic neuropathy, postherpetic neuralgia, and chemotherapy-induced peripheral neuropathy. In addition, magnesium treatment is reportedly able to alleviate fibromyalgia, dysmenorrhea, headaches, and acute migraine attacks. Although magnesium plays an evolving role in pain management, better understanding of the mechanism underlying its antinociceptive action and additional clinical studies is required to clarify its role as an adjuvant analgesic.

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Section: Magnesium and Perioperative Painmentioning

confidence: 93%

Magnesium and Pain

Shin

Hwan

2020

Nutrients

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“…Magnesium sulfate has been used for analgesia in various surgeries, such as hysterectomy, abdominal surgery, orthopedics, and the thorax, which reduces pain levels and opioid usage [17][18][19][20][21]. Magnesium is used as a loading dose or infusion for regional anesthesia, intra-articular injection, and oral administration after surgery [11][12][13]. Intra-articular injection of magnesium after arthroscopy helped patients to move faster and reduce their pain [22].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, intraoperative magnesium injection can lead to dangerous side effects, such as prolonged muscle relaxant effects, prolonged recovery, and sometimes severe heart disturbances. The effects of magnesium on the bispectral index (BIS) and sedation were also studied, and it was shown that magnesium could significantly reduce BIS [ 12 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Magnesium inhibits calcium channels and N-methyl-D-aspar-tate (NMDA) receptors for pain relief; however, the mechanism is unknown [10]. Magnesium sulfate is used for local and regional anesthesia, intravenous injections, and oral consumption [11][12][13]. However, magnesium can prolong muscle relaxation, sedation, slow recovery time, dysrhythmia, and negative inotropic effects [5,14].…”

Section: Introductionmentioning

confidence: 99%

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Effect of intravenous magnesium on postoperative pain control for major abdominal surgery: a randomized double-blinded study

Yazdi

Esmaeeli²,

Gilani³

2022

Anesth Pain Med

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Background: Magnesium sulfate has been used in different studies as a pain control agent; however, the results are contradictory. This study aimed to evaluate the effect of magnesium sulfate on postoperative pain management during abdominal surgery. Methods: This randomized double-blinded study involved 84 patients candidates for abdominal surgery, who were divided into two groups (42 patients in each group). In the magnesium group, 25 mg/kg magnesium sulfate was infused for 1 h; then, 100 mg/kg/24 h was infused in the intensive care unit. The patients’ pain intensity, which was the primary outcome, was assessed using the numeric rating scale (NRS) every 3 h. If the NRS was > 3, morphine was used and evaluated as a secondary outcome after 24 h. The patients and nurses who assessed the patients were blinded to the drug groups. The results were analyzed using SPSS ver. 19 software, and statistical significance was set at P < 0.05.Results: Age, sex, body mass index (BMI) and surgery duration were similar between the groups. The pain intensity was 4 ± 0.2 in the control and 3.8 ± 0.2 in the magnesium group at first and then 3.98 ± 0.2 in the control and 3.45 ± 0.2 in the magnesium group at the third hour, which were similar in both groups (P = 0.39 and P = 0.17, respectively), but thereafter between 6 and 24 h, the pain severity was significantly lower in the magnesium group (4.4 ± 1.3 in the control and 3.34 ± 1 in the magnesium group at 6th hour and P = 0.001). In addition, morphine intake in the first 24 h in the two groups had a significant difference, with 13.2 ± 5.7 in control group and 8 ± 3.5 in magnesium group (P = 0.001). Hemodynamic state and muscle relaxation were similar in both groups.Conclusions: In this study, intravenous magnesium sulfate after abdominal surgeries for 24 h resolved the pain intensity after six hours and reduced morphine dosage.

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“…The reason lies in the invasive operation on both the soft and the hard tissues in order to eliminate all resistances as mentioned above during the extraction of impacted teeth 4,5 . This kind of invasive operation will cause different degrees of trauma, which will further increase the postoperative pain and the discomfort of patients 6,7 . Therefore, reducing surgical trauma is important for the extraction of impacted teeth.…”

Section: Discussionmentioning

confidence: 99%

New bone conservation technology of impacted teeth extraction

2021

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Object: To introduce an impacted wisdom tooth extraction method based on the new concept of bone preservation.Methods: About 60 cases with impacted mandibular third molars in our clinic were reviewed from January to March 2021. Two senior attending doctors were selected to perform the extraction operations. Two different techniques were used to extract the impacted third molar. The duration of the operation time, the postoperative swelling scaling and the pain scaling were reviewed. Research results:There was no significant difference between the two groups in operation time, the postoperative swelling scaling and the pain scaling. Both methods can remove wisdom teeth, and clinicians should choose less invasive methods. Conclusion:The extraction of impacted teeth should be improved with more precision and less trauma.

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Effect of orally administered magnesium on postoperative pain level and trismus after surgical removal of the lower third molars: a randomized, double-blind, placebo-controlled trial

Cited by 6 publications

References 42 publications

Magnesium and Pain

Magnesium and Pain

Effect of intravenous magnesium on postoperative pain control for major abdominal surgery: a randomized double-blinded study

New bone conservation technology of impacted teeth extraction

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