Effect of orally administered cimetidine and ranitidine on abomasal luminal pH in clinically normal milk-fed calves

Abstract

Abomasal acid secretion in milk-fed calves is mediated in part by histamine type-2 receptors. Cimetidine and ranitidine may be efficacious in the treatment of abomasal ulcers in milk-fed calves.

Ultrasonographic measurement of abomasal volume, location, and emptying rate in calves

“…Each calf had a cannula b surgically placed in the abomasal body, as previously described. 21 After the calves had recovered from surgery and anesthesia, they were kept unrestrained in individual stalls that were bedded with sawdust; calves were fed (60 mL/kg) twice a day with a medicated all milk-protein milk replacer c (minimum crude protein, 20%; minimum crude fat, 20%; maximum crude fiber, 0.15%; minimum calcium, 0.5%; maximum calcium, 1.0%; minimum phosphorus, 0.6%; and decoquinate, 45.4 g/ton [providing 0.5 mg/kg of body weight]) and had access to fresh water at all times.…”

“…Each calf had a cannula b surgically placed in the abomasal body, as previously described. 21 After the calves had recovered from surgery and anesthesia, they were kept unrestrained in individual stalls that were bedded with sawdust; calves were fed (60 mL/kg) twice a day with a medicated all milk-protein milk replacer c (minimum crude protein, 20%; minimum crude fat, 20%; maximum crude fiber, 0.15%; minimum calcium, 0.5%; maximum calcium, 1.0%; minimum phosphorus, 0.6%; and decoquinate, 45.4 g/ton [providing 0.5 mg/kg of body weight]) and had access to fresh water at all times.Experimental protocols-At least 2 days after surgical cannulation, at least 36 hours after completion of the previous ultrasonographic study, and at least 10 hours after the previous feeding of milk replacer, each calf was weighed and placed in a movable calf stall that allowed sitting and standing but prevented extensive lateral and forward movement. Calves were between 7 and 40 days of age when studied in 3 separate experiments.…”

Assessment of the effects of erythromycin, neostigmine, and metoclopramide on abomasal motility and emptying rate in calves

“…Each calf had a cannula b surgically placed in the abomasal body, as previously described. 34 After the calves recovered from surgery and anesthesia, they were kept unrestrained in individual stalls that were bedded with sawdust; calves were fed (60 mL/kg) twice a day with a commercially available medicated all milk-protein milk replacer c (minimum crude protein, 20%; minimum crude fat, 20%; maximum crude fiber, 0.15%; minimum calcium, 0.5%; maximum calcium, 1.0%; minimum phosphorus, 0.6%; and decoquinate 45.4 g/ton [providing 0.5 mg/kg of body weight]) and had access to fresh water at all times. The calves had been used previously in a scintigraphic study 35 to validate ultrasonography as a measure of abomasal location and emptying rate.…”

Determination of abomasal emptying rate in suckling calves by use of nuclear scintigraphy and acetaminophen absorption

“…A cannula b was surgically inserted in the abomasal body of each calf within 5 days after birth, as described elsewhere. 22 After the calves recovered from surgery, they were housed unrestrained in separate stalls bedded with wood shavings. Calves were fed twice per day.…”