Effect of Oral Vitamin E on Oxidative Stress in Diabetic Kidney Disease：A Protocol of Systematic Review and Meta-Analysis

Abstract

BackgroundThe occurrence and progression of diabetic nephropathy is closely related to oxidative stress response. Vitamin E, as a lipid soluble antioxidant, has a long history of use. It may improve oxidative stress response to some extent, but there is no relevant support of evidence-based medicine. The purpose of this study was to systematically evaluate the effect of oral vitamin E on oxidative stress response in patients with diabetic nephropathy.MethodsA computer was used for retrieving data from English database (PubMed, Embase, Web of Science, the Cochrane Library) and Chinese database (CNKI, Wangfang, VIP, CBMDISC) between the creation time to October 2020, a randomized controlled clinical study on oral vitamin E treatment of diabetic nephropathy. Two investigators conducted data extraction and literature quality evaluation for the included studies, and a Meta- analysis on the included articles was conducted using RevMan5.3 software.ConclusionsThis study will summarize up-to-date high-quality RCTs to assess the antioxidant effects of oral vitamin E on diabetic nephropathy. The findings of this study will help to determine whether oral vitamin E is effective and safe in patients with diabetic nephropathy.Systematic review registration: PROSPERO CRD42020213945