Effect of Oral Tizanidine on Local-anesthetic Infiltration Pain during Epidural Catheterization

Imanaga, Kazuyuki; Wajima, Zen’ichiro; Inoue, Tetsuo; Ogawa, Ryo

doi:10.1272/jnms.71.105

Cited by 10 publications

(22 citation statements)

References 34 publications

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“…Modifications firstly concerned the aromatic core by introducing various substituents or by replacing the phenyl ring with the pyridine (60), pirimidine (for example moxonidine (61) [143]) or thiophene ones (62), or else by enlarging it (63) as in the case of tizanidine (18), recommended as premedication for patients undergoing epidural catheterization [144].…”

Section: Clonidine Analogsmentioning

confidence: 99%

Agonists and Antagonists Targeting the Different α2-Adrenoceptor Subtypes

Gentili

Pigini²,

Piergentili³

et al. 2007

CTMC

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Chemical and biological strategies have provided evidence for alpha(2)-receptor heterogeneity, to date classified in three different subtypes, alpha(2A), alpha(2B), and alpha(2C). These are widely distributed throughout the body and mediate numerous effects; therefore, the potential therapeutic indications of agonists and antagonists are numerous. Nevertheless, the lack of subtype-selectivity of the well-known compounds represents a major limit for their use. SAR studies may help to design new and more selective drugs.

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Section: Clonidine Analogsmentioning

confidence: 99%

Agonists and Antagonists Targeting the Different α2-Adrenoceptor Subtypes

Gentili

Pigini²,

Piergentili³

et al. 2007

CTMC

View full text Add to dashboard Cite

show abstract

“…As the spinal cord is the primary site of tizanidine effect and it prevents the release of excitatory amino acids (aspartic and glutamic acids) by stimulating the 2α presynaptic receptors, this drug can be useful to reduce postoperative pain and the need for tranquilizers through inhibition of CS. [ 3 7 ] As far as tizanidine can be administered orally, this procedure is much preferable than injection procedures.…”

Section: Introductionmentioning

confidence: 99%

The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy

2016

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Background:Cholecystectomy is considered as the most important and relatively common postoperative pain control often begins in recovery room by using systemic narcotics that may have some side effects. The aim of this study is to evaluate the effect of premedication with oral tizanidine on pain relief after elective laparoscopic cholecystectomy.Materials and Methods:In this double-blinded clinical trial, 70 adults of American Society of Anesthesiologist physiologic state 1 and 2 scheduled for elective laparoscopic cholecystectomy under general anesthesia were studied and randomly divided in two study and control groups. Ninety minutes before the induction of anesthesia, patients received either 4 mg tizanidine (study group) orally in 50cc or the same volume of plain water as a placebo (control group). Then, the vital signs, pain intensity, duration of stay in recovery, and the analgesic consumption were measured and then compared in both groups during 24 h postoperatively.Results:There was no significant difference in patient characteristics, with respect to age, weight, gender, and duration of anesthesia and surgery between the groups (P > 0.05). The pain intensity, need for analgesic drugs (34.57 ± 8.88 mg vs. 101.86 ± 5.08 mg), and the duration of stay in recovery room (67.43 ± 1.59 min vs. 79.57 ± 5.48 min) were significantly lower in tizanidine group than that of the control group.Conclusion:Oral administration of 4 mg tizanidine before laparoscopic cholecystectomy reduces postoperative pain, opioid consumption, and consequence of the duration of stay in recovery room without any complication.

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“…Tizanidine is a α 2 -receptor agonist derived from Clonidine which possesses sedative, anxiolytic and analgesic properties. Its major side-effects include heart rate and blood pressure decrease which are observed less frequently when compared to the side effects of the remaining drugs in this class, such as Clonidine (4). α 2 -agonists have sedative, anxiolytic and analgesic effects and serve to decrease autonomic nervous system responses, i.e., increase in blood pressure and heart rate and the catecholamines release, caused by preoperative anxiousness, laryngoscopy, tracheal intubation and stimulation due to the surgery (5); They are effective in postoperative shivering control as well (6, 7).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Oral Tiazinidine Effects on [intraoperative] Hemodynamic Responses During Direct Laryngoscopy Under General Anesthesia

Tabari

Alipour

Esalati

2013

Iran Red Crescent Med J

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BackgroundDirect laryngoscopy and tracheal intubation can result in blood pressure and heart rate increase which in turn may lead to myocardial ischemia, cerebral hemorrhage, and even death in susceptible patients. Tizanidine is α2-receptor agonists that suppresses central sympathetic system.ObjectivesThis study evaluates the effects of oral Tizanidine on hemodynamic responses during operations and aims to determine the appropriate Propofol dosage to maintain anesthesia under BIS monitoring.Materials and MethodsA double-blind clinical trial has been performed on 70 candidates for elective abdominal surgery undergoing general anesthesia in Educational Hospital of Ghaem, Mashhad, Iran. 35 randomly selected patients (the case group) were given 4 mg of oral Tizanidine 90 minutes before the induction of anesthesia whereas the remaining subjects (the control group) were given placebo. Blood pressure and heart rate before and after induction of anesthesia, and after intubation and extubation, existence of postoperative shivering, and the needed Propofol dosage were measured and recorded. Data analysis was done with T-test and Chi-squared test, using SPSS software version 16.ResultsVariations of blood pressure and heart rate after anesthesia induction, intubation and extubation were less in Tizanidine group generally. Postoperative shivering was reported in 28.6% and 11.4% of patients in control and case group respectively. Average propofol needed dose for anesthesia maintenance in case group was 25% less than the needed amount in the control group.ConclusionsUsing oral Tizanidine as a premedication, yielded stability in blood pressure and heart rate during surgery and decreased required Propofol. Considering its short duration of action, Tizanidine use as a premedication is recommended for sedation and stabilization of hemodynamic responses during the operations.

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Effect of Oral Tizanidine on Local-anesthetic Infiltration Pain during Epidural Catheterization

Cited by 10 publications

References 34 publications

Agonists and Antagonists Targeting the Different α2-Adrenoceptor Subtypes

Agonists and Antagonists Targeting the Different α2-Adrenoceptor Subtypes

The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy

Evaluation of Oral Tiazinidine Effects on [intraoperative] Hemodynamic Responses During Direct Laryngoscopy Under General Anesthesia

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Effect of Oral Tizanidine on Local-anesthetic Infiltration Pain during Epidural Catheterization

Cited by 10 publications

References 34 publications

Agonists and Antagonists Targeting the Different &#945;2-Adrenoceptor Subtypes

Agonists and Antagonists Targeting the Different &#945;2-Adrenoceptor Subtypes

The effect of oral tizanidine on postoperative pain relief after elective laparoscopic cholecystectomy

Evaluation of Oral Tiazinidine Effects on [intraoperative] Hemodynamic Responses During Direct Laryngoscopy Under General Anesthesia

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Product

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Agonists and Antagonists Targeting the Different α2-Adrenoceptor Subtypes

Agonists and Antagonists Targeting the Different α2-Adrenoceptor Subtypes