Effect of Oral Prostaglandin E1 on Intestinal Transit in Man

Misiewicz, J. J.; Waller, Sheila L.; Kiley, Nancy; Horton, E. W.

doi:10.1016/s0140-6736(69)92012-1

Cited by 152 publications

(22 citation statements)

References 14 publications

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“…The results of animal experiments show that PGEX adminis tered orally loses its effect on the gastric secretion since it is metabolised in the upper gastrointestinal tract [13]. The influence exercised on the intestinal motility after oral administration of PGEX is possibly due to its metabolites [12].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Prostaglandin E<sub>1</sub> on the Pentagastrin-Stimulated Gastric Secretion in Man

et al. 1971

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In 8 volunteer male test subjects having an average age of 25.5 years, the influence of i.v. infused PGE₁ on the gastric secretion stimulated with pentagastrin was investigated. Pentagastrin was infused continuously over a period of 2 h at a dose of 2 μg/kg body wt./h. Sixty minutes after the start of the infusion, an additional 460 μg PGE₁ (5–7 μg/kg body wt.) in 250 ml saline were infused over a period of 30 min. During the infusion of PGE₁ the volume and H ion output of the gastric juice were significantly reduced. The most marked reduction occurred in the time period between 15 and 45 min after the start of PGE₁ administration. With these experiments it has been proved for the first time that with i.v. administration of PGE₁ as opposed to oral administration, not only the basal but also the stimulated human gastric secretion is inhibited. The side effects in this series of experiments were tolerable.

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Section: Discussionmentioning

confidence: 99%

The Effect of Prostaglandin E<sub>1</sub> on the Pentagastrin-Stimulated Gastric Secretion in Man

et al. 1971

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“…Under this pretreatment intravenous injection of iloprost had also no effect. * glandins that stimulate intestinal secretion in the small and large intestine [2][3][4]10]. This assumption is based on enteropooling experiments in which prostacyclin did not enhance intraluminal fluid accumulation but inhibited enteropooling caused by PGEz or cholera toxin.…”

Section: Ileal Loopsmentioning

confidence: 99%

“…Whereas prostaglandins of the Eseries stimulate intestinal secretion [2][3][4], prostacyclin and its stable analogue iloprost are considered to have no secretory activity on the intestinal mucosa. In 124 enteropooling experiments it was shown that PGh and iloprost inhibit the secretory activity ofPGE 2 , choleratoxin and ricinoleic acid [5,6].…”

Section: Introductionmentioning

confidence: 99%

Effect of the stable prostacyclin analogue iloprost on water and electrolyte transfer of the rat ileum and colon in vivo

Goerg

Wanitschke

Becker

et al. 1988

Eur J Clin Investigation

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The effect of iloprost on water and ion transfer was measured simultaneously in tied-off loops of the rat ileum and colon in vivo. (1) In the ileal loops iloprost had no effect on water and ion transfer neither by intraluminal, nor intraaortal or intravenous application. (2) In the colonic loops only intraaortal bolus application of the high dose of 500 micrograms iloprost significantly decreased net water, sodium and chloride absorption, but did not induce net secretion. (3) Inhibition of endogenous prostaglandin synthesis by indomethacin did not change net water and electrolyte transfer in the ileum and colon. (4) Under this pretreatment i.v.-application of 100 micrograms iloprost, ineffective without indomethacin, induced a net secretion of water and sodium and inhibited absorption of chloride in the colon. (5) At the same time iloprost had no effect in the ileal loops of the same animals. (6) Potassium secretion was activated already by 100 micrograms iloprost administered intraluminally. We conclude from this study, that prostacyclin and iloprost have a specific secretory action in the colon. However this effect is masked under in-vivo conditions, either by interactions of ineffective prostaglandin metabolites with the concerned receptors or by counteracting prostaglandins, and becomes evident only after inhibition of the prostaglandin biosynthesis.

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“…13, 16]. Early studies have concentrated on the effects o f orally administered PGE| on the gastrointestinal tract, and it was noted that the ingestion o f small amounts o f PGE| re sulted in increased gastrointestinal motility and diarrhea [8], Such effects could have been produced by PGEi that reached the muscle coat o f the intestine through the mu cosa in concentrations sufficient to produce propulsive activity [11]. Other studies claim that specific and unspecific [6] stimuli may provoke PG release which plays a role in the control of gastrointestinal motility [1].…”

mentioning

confidence: 99%

Factors Regulating Prostaglandin Uptake by Rat Small Intestine

Nassar¹,

Haddad²,

Khuri³

1982

Digestion

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The uptake of prostaglandin E₁ by rat intestine mucosal strips was investigated. The results indicate that: (1) PGE₁ did not accumulate in the epithelial cells of rat intestine. The intracellular to extracellular distribution ratio did not reach unity in spite of the extended periods of incubation. (2) A decrease in the sodium gradient across the brush-border membrane of intestinal cells significantly inhibited PGE₁ uptake by the mucosal strips. (3) PGE₁uptake increases with increasing concentration of potassium in the incubation medium with a tendency for saturation at high K⁺ levels. (4) Calcium and magnesium ions had no effect on the steady-state uptake of PGE₁ by the epithelial cells of rat intestine. (5) Addition of sodium carbonate or phosphate to the incubation medium significantly decreased PGE₁ uptake by the intestinal cells. (6) Further studies of PGE₁ uptake reveal a temperature-dependent process with a Q₁₀ of 2.8.

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Effect of Oral Prostaglandin E1 on Intestinal Transit in Man

Cited by 152 publications

References 14 publications

The Effect of Prostaglandin E<sub>1</sub> on the Pentagastrin-Stimulated Gastric Secretion in Man

The Effect of Prostaglandin E<sub>1</sub> on the Pentagastrin-Stimulated Gastric Secretion in Man

Effect of the stable prostacyclin analogue iloprost on water and electrolyte transfer of the rat ileum and colon in vivo

Factors Regulating Prostaglandin Uptake by Rat Small Intestine

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