Effect of Oral Prophylactic Measures on the Occurrence of Pre-Eclampsia (OP-PE) in High-Risk Pregnant Women: A Cluster Randomized Controlled Trial

Kanouté, Aida; Gare, Jocelyne; Méda, Nicolas; Viennot, Stéphane; Tramini, Paul; Fraticelli, Laurie; Carrouel, Florence; Bourgeois, Denis

doi:10.3390/mps4030061

Cited by 2 publications

(2 citation statements)

References 38 publications

(36 reference statements)

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“…This cross-sectional study is a part of the randomized controlled trial OP-PE protocol published by Kanoute et al (2021) and registered at ClinicalTrials.gov (NCT04989075). The ethical committee of Dakar (Senegal) approved the protocol on 8 June 2021 (000086/MSAS/ CNERS/SP).…”

Section: Study Design and Settingmentioning

confidence: 99%

Periodontal pathogens of the interdental microbiota in a 3 months pregnant population with an intact periodontium

Carrouel,

Kanoute,

Lvovschi

et al. 2023

Front. Microbiol.

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Steroid hormones and the oral microbiota of pregnant women both appear as cumulative risk factors for gingivitis. This cross-sectional study, using real-time PCR, investigated the composition and diversity of the microbiota in interdental spaces of 3 months pregnant women with intact periodontium according the 2018 EFP/AAP classification. Bacteria identified were belonged to the red (Porphyromonas gingivalis Treponema denticola, and Tanerella forsythia), orange (Fusobacterium nucleatum, Prevotella intermedia, Campylobacter rectus, and Parvimonas micra), and green (Eikenella corrodens and A. actinomycetencomitans) Socransky complexes. Approximatively 109.11 bacteria were counted per interdental space in pregnant women. Bacteria from the red complex represented 33.80% versus 62.81% for the orange group versus 3.39% for the green group of the total number spread over the 3 groups. Dietary habits and physical activity did not have a significant impact on interdental microbiota, although a decrease in the median amount of 9 periodontopathogens was observed when fruit and vegetable consumption increased. Pregnant women who brushed their teeth at least twice a day had lower counts of total bacteria and 9 periodontal pathogens than those who brushed less. In 3 months pregnant women at high risk of periodontal disease (>30% bleeding sites), the dendogram revealed 2 clusters of the 9 periodontopathogens. This provides further support for the “key pathogen” hypothesis, among which Porphyromonas gingivalis plays a key role, indicating that specific bacteria in limited quantities can influence the host immune system and convert the microbiota from symbiotic to dysbiotic to induce inflammatory disorder. As a result, this study reported that 3 months pregnant women with healthy periodontium had high levels of interdental bleeding and a dysbiotic microbiota with periodontal pathogens of the Socransky orange and red complexes. These subjects were therefore potentially at increased risk of developing periodontal disease and, consequently, an adverse pregnancy outcome. So, preventive oral prophylaxis measures, in particular individual interdental prophylaxis, should be implemented as soon as pregnancy is established.

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Section: Study Design and Settingmentioning

confidence: 99%

Periodontal pathogens of the interdental microbiota in a 3 months pregnant population with an intact periodontium

Carrouel,

Kanoute,

Lvovschi

et al. 2023

Front. Microbiol.

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“…This analysis was a part of the randomized controlled trial OP-PE protocol published by Kanoute et al (2021) [28] and registered at ClinicalTrials.gov (NCT04989075). Two hundred and twenty women at 3 months of pregnancy were recruited between March 2022 and August 2022 at the first obstetrical visit to 6 National Hospital Centers of Dakar (Senegal).…”

Section: Study Design and Settingmentioning

confidence: 99%

Prevalence, Severity of Extension, and Risk Factors of Gingivitis in a 3-Month Pregnant Population: A Multicenter Cross-Sectional Study

Gare

Kanouté

Orsini

et al. 2023

JCM

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The scope of this study was to assess the prevalence, severity of extension, and risk factors of gingivitis among pregnant women. In this cross-sectional study, 220 nulliparous women at 3 months of pregnancy were recruited in 2022 at the first obstetrical visit in Dakar, Senegal. Demographic characteristics, lifestyle habits, prenatal clinical status, and oral clinical parameters were recorded. Multivariable logistic regression modeling was used to assess relationships between gingivitis and risk factors. Eighty-eight percent of women had gingivitis, 15% were classified as moderate and 73% as severe. A total of 66.7% (95% CI [28.8–92.1]) of the sites had bleeding on interdental brushing. The odds for gingivitis decreased significantly for women consuming more than five portions of fruits and vegetables per day (OR = 0.15; 95% CI [0.03–0.66]) and increased in women who had a professional activity (OR = 6.75; 95% CI [1.27–35.87]) and high education. Concomitantly, the percentage of dental plaque (OR = 131.6; 95% CI [10.80–1619.71] and the severity of clinical attachment loss (OR = 7.70; 95% CI [3.16–18.92]) were important risk factors. Inverse associations were observed with increasing body mass index (OR = 0.76; 95% CI [0.63–0.93]). Our results underline that gingivitis cases and bleeding were particularly high among 3-month pregnant women. Literacy and adequate oral hygiene actions to modify behaviors and to achieve meticulous biofilm disorganization could make a favorable change in the gingival health outcome. Additionally, further research is necessary to precisely determine the role of biofilm-induced gingivitis and systemic-induced gingivitis in improving gingival conditions.

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Effect of Oral Prophylactic Measures on the Occurrence of Pre-Eclampsia (OP-PE) in High-Risk Pregnant Women: A Cluster Randomized Controlled Trial

Cited by 2 publications

References 38 publications

Periodontal pathogens of the interdental microbiota in a 3 months pregnant population with an intact periodontium

Periodontal pathogens of the interdental microbiota in a 3 months pregnant population with an intact periodontium

Prevalence, Severity of Extension, and Risk Factors of Gingivitis in a 3-Month Pregnant Population: A Multicenter Cross-Sectional Study

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