Effect of Oral Pregabalin as Preemptive Analgesic in Patients Undergoing Lower Limb Orthopedic Surgeries under Spinal Anaesthesia

Sebastian, Bon; Talikoti, Anand T; Nelamangala, Kiran; Krishnamurthy, Dinesh

doi:10.7860/jcdr/2016/18854.8081

Cited by 19 publications

(18 citation statements)

References 9 publications

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“…16,17 Our study also concluded the same as sedation was the most common side effect followed by nausea. Similar results were reported by Sebastian B et al 15 who found that hypotension (33.33%) and dizziness (26.66%) as the most common side effects. Akhavanakbari and colleagues however found that nausea and vomiting scores and sedation levels at 2 h and 6 h were reduced in the pregabalin group.…”

Section: Discussionsupporting

confidence: 90%

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The role of preoperative oral pregabalin on acute post?operative pain after orthopedic lower limb surgery

Jain¹,

Sahni²,

Sreen³

et al. 2020

IJOR

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Introduction: Postoperative pain after orthopedic surgery has remained a challenging problem, which prolongs hospital stay and early rehabilitation. Pregabalin comes under class of gabapentinoids that have been used in postoperative pain in arthroplasty and spine surgeries but studies regarding its role as preemptive analgesia in orthopedic limb surgeries are very few. Aim: To study the efficacy and safety of pregabalin as preemptive medication for acute postoperative pain management in patients undergoing orthopedic lower limb fracture surgeries. Materials and Methods: A randomized double blinded prospective study was undertaken. Sixty patients were enrolled with age between 18-70 years and were divided into 2 groups. Group A -received 150mg of oral pregabalin capsule, Group Breceived matched colour empty capsules. Standard spinal anaesthesia was given. Breakthrough analgesia was given with Inj. Diclofenac 1.5 mg/kg i/m. Assessment of pain was done with visual analog scale (VAS). Results: There was marked reduction in postoperative VAS score in group A and the amount of breakthrough analgesia needed in the 24hour postoperative period was also much lower in the Group A as compared to the Group B. Conclusion: 150mg of oral pregabalin as preemptive medication offers satisfactory postoperative analgesia in orthopaedic lower limb fracture surgeries with very few undesirable side effects.

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Section: Discussionsupporting

confidence: 90%

“…A number of authors showed pregabalin 150mg is a better choice. 14,15 Few studies used multiple doses of pregabalin pre and postoperatively and others showed only a single preoperative dose of pregabalin 150mg is sufficient. 4,5 Headache, dizziness and sedation are the most commonly reported adverse effects of pregabalin (22-29%).…”

Section: Discussionmentioning

confidence: 99%

The role of preoperative oral pregabalin on acute post?operative pain after orthopedic lower limb surgery

Jain¹,

Sahni²,

Sreen³

et al. 2020

IJOR

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“…At other points of time, however, the scores were comparable between the groups. The findings of Sebastian et.al, in their study also showed increased sedation scores with pregabalin when compared to control, in terms of the proportion of patients having a higher Ramsay sedation score 10 .…”

Section: Discussionmentioning

confidence: 67%

Preemptive use of oral gabapentin or pregabalin for acute postoperative pain following lower limb orthopaedic surgery under spinal anaesthesia

Acharya

Ghimire

Bhattarai

et al. 2019

J. Kathmandu Med. Coll.

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Background: Postoperative pain is a major cause of perioperative morbidity and functional impairment. Preemptive analgesia is an analgesia regimen instituted before the surgery, to desensitize the pain pathways. Pregabalin and gabapentin have been claimed to be effective in reducing postoperative pain without significant alterations in hemodynamics. Objectives: This study was conducted to compare the effectiveness of pregabalin and gabapentin in reducing postoperative pain, total opioid consumption, postoperative nausea and vomiting and sedation in patients undergoing lower limb orthopaedic surgeries under spinal anaesthesia. Methodology: Eighty patients undergoing lower limb orthopaedic surgeries under spinal anaesthesia were divided into two groups, to either receive 300mg gabapentin or 150mg pregabalin, one hour before surgery. The patients were evaluated at one, two, six, 12 and 24 hours postoperatively and Visual Analogue Scale score for pain, postoperative nausea vomiting, and sedation score were monitored. Tramadol 50 mg was used as rescue analgesic and total consumption over 24 hours was recorded. Results: The mean duration of postoperative analgesia was significantly higher with pregabalin (282±106 minutes versus 234 ± 97minutes, p=0.009). The sedation score was significantly higher with pregabalin in the first hour (p=0.001). The total tramadol consumption was higher with gabapentin; however, it was statistically insignificant. The occurrence of postoperative nausea and vomiting was comparable between the groups. Minor adverse effects such as dizziness, sedation and headache were observed in both groups. Conclusion: Pregabalin 150 mg orally significantly increases the duration of postoperative analgesia than gabapentin 300mg following lower limb orthopaedic surgeries. Although sedation is frequently observed, it doesn’t alter the hemodynamics and thus, may be used safely.

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“…14 Pregabalin has been used in preemptive analgesia for the treatment of laparoscopic cholecystectomy, laparoscopic hysterectomy, arthroscopic Bankart repair, arthroscopic rotator cuff repair, lumbar fusion surgery, total knee arthroplasty, septoplasty, laparoscopic prostatectomy, radical neck dissection surgery, lower limb orthopedic surgery, molar extraction and endoscopic thyroidectomy. 9,15,16,17,18,19,20,21,22,23,24, 25,26 gabapentinoids was able to reduce postoperative pain, total morphine consumption, and morphine-related complications following arthroscopic shoulder surgery. Further studies should determine the optimal dose and whether pregabalin is superior to gabapentin in controlling acute pain after shoulder surgery.…”

Section: Introductionmentioning

confidence: 99%

Eficacia y seguridad de la analgesia preventiva con gabapentinoides para pacientes sometidos a cirugía artroscópica de hombro: una revisión sistemática y metanálisis

Galindo-Avalos

Colin-Vázquez²,

López-Valencia³

et al. 2019

Acta Ortopédica Mexicana

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Effect of Oral Pregabalin as Preemptive Analgesic in Patients Undergoing Lower Limb Orthopedic Surgeries under Spinal Anaesthesia

Cited by 19 publications

References 9 publications

The role of preoperative oral pregabalin on acute post?operative pain after orthopedic lower limb surgery

The role of preoperative oral pregabalin on acute post?operative pain after orthopedic lower limb surgery

Preemptive use of oral gabapentin or pregabalin for acute postoperative pain following lower limb orthopaedic surgery under spinal anaesthesia

Eficacia y seguridad de la analgesia preventiva con gabapentinoides para pacientes sometidos a cirugía artroscópica de hombro: una revisión sistemática y metanálisis

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