Effect of Oral Phosphate and Alendronate on Bone Mineral Density When Given as Adjunctive Therapy to Growth Hormone Replacement in Adult Growth Hormone Deficiency

Ahmad, Aftab; Durham, B; Joshi, AA; Fraser, William D.; Vora, Jiten

doi:10.1210/jc.2010-1929

Cited by 10 publications

(1 citation statement)

References 42 publications

(72 reference statements)

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“…GH promotes the longitudinal bone growth in children and plays an important role in bone mass maintenance in adults. In addition, GH stimulates the activity of chondrocytes and osteoblasts and influences the proliferation and differentiation of their precursors [24,25]. Furthermore, GH regulates the secretion of parathyroid hormone, thereby affecting bone remodeling.…”

Section: Discussionmentioning

confidence: 99%

Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency

Zhong

Zheng

et al. 2020

Biochemistry Research International

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Aim. Adult growth hormone deficiency (AGHD) is associated with an increased risk of fractures. The interactions between various body composition and bone are known to be complex in nature. However, very few studies have examined this crosstalk in AGHD. In this study, we sought to investigate the relationship between various parameters of body composition and bone mineral density (BMD) as well as determine the role of visceral fat in determining the bone mass in patients with AGHD. Methods. We conducted a cross-sectional study on 57 patients with AGHD. Anthropometry, biochemistry, and analysis of body composition and BMD were performed according to standard protocols. Male and female patients were classified into those with osteoporosis and those without osteoporosis (normal subjects and patients with osteopenia). Further, we analyzed the correlation between the BMD and measurements obtained for various body composition parameters in male and female AGHD patients. Results. Our findings indicated that among female AGHD patients, those with osteoporosis had a significantly higher levels of fat mass (FM) and visceral adipose tissue mass (VATM) (both, P<0.05) than those without osteoporosis. Further, Pearson correlation analysis showed that the values of age, body mass index (BMI), FM, and VATM correlated negatively with BMD in women with AGHD (all P<0.05); however, this association was not noted in men. After adjusting for the other covariates, VATM was found to be independently correlated with the BMD in female patients with AGHD. Conclusions. A close correlation was noted between VATM and BMD in female patients with AGHD.

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Section: Discussionmentioning

confidence: 99%

Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency

Zhong

Zheng

et al. 2020

Biochemistry Research International

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The effects of high serum growth hormone and IGF-1 levels on bone mineral density in acromegaly

et al. 2016

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Update on vertebral fractures in pituitary diseases: from research to clinical practice

et al. 2021

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Effect of Oral Phosphate and Alendronate on Bone Mineral Density When Given as Adjunctive Therapy to Growth Hormone Replacement in Adult Growth Hormone Deficiency

Abstract: Phosphate and alendronate therapy given in combination with GHR confer advantage in terms of BMD increase. Phosphate appears to exert its effect by increasing PTH target-organ action, whereas alendronate acts primarily through reduction in bone resorption.

Cited by 10 publications

References 42 publications

Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency

Association between Visceral Fat and Bone Mineral Density in Both Male and Female Patients with Adult Growth Hormone Deficiency

The effects of high serum growth hormone and IGF-1 levels on bone mineral density in acromegaly

Update on vertebral fractures in pituitary diseases: from research to clinical practice

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