Effect of Oral Methadone on ECG Characteristics and Endocrine Hormonal Changes and Their Inter-relationship

Bonakdaran, Shokoufeh; Daloee, Mahdi Hassan Zadeh; Manteghi, Ali Akhoondpoor; AkbariRad, Mina; Firoozi, Abdollah; Akbarirad, Fatemeh

doi:10.2174/1871530316666161026142930

Cited by 3 publications

(3 citation statements)

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“…Methadone therapy for opioid abuse does not change FSH levels in pre-and post-menopausal females (30). Psychoneuroendocrinology consuming prescribed sustained-action opioids in women receiving opiate drug treatment for pain management, including methadone, lead to reductions in FSH levels, whereas FSH levels in pre-menopausal females are not changed from premenopausal controls.…”

Section: Effect Of Methadone On Luteinizing Hormone and Follicle Stim...mentioning

confidence: 95%

“…Serum samples from females receiving methadone for pain management revealed no changes in estradiol levels compared to control group samples (32). Bonakdaran et al reported that methadone has no significant effect on estradiol levels in women receiving methadone therapy for opioid abuse (30). However, another study indicated that estradiol levels reduce in menopausal women receiving methadone for chronic pain in comparison to the pre-menopausal control group (31).…”

Section: Effect Of Methadone On Estrogenmentioning

confidence: 96%

“…Bonakdaran et al found that methadone treatment for opioid abuse in menopause women does not alter LH levels compared to controls without methadone (30). According to another study, in women who consumed prescribed sustained-action opioids (including methadone) for control of nonmalignant pain, LH levels decreased compared to control pre-and post-menopausal females, and more significant effects were observed in post-menopausal women.…”

Section: Effect Of Methadone On Luteinizing Hormone and Follicle Stim...mentioning

confidence: 98%

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The complications of tramadol and methadone use to women’s sexual hormone

Saravani,

Ramezannezhad,

Delpisheh

et al. 2023

J Shahrekord Univ Med Sci

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Background and aims: Tramadol and methadone are synthetic opioid drugs that are widely used in various fields of medicine. This review article was performed to investigate the hormone disturbance of long-term tramadol and methadone use in women. Methods: Keywords were determined using the MeSH browser and then searched in ISI, Scopus, EMBASE, and PubMed databases on 25.5.2022. The articles with non-English language, articles whose full text was not retrieved, and studies that were irrelevant to the aim of this study were excluded from the investigation. Results: Methadone and tramadol affected a sexual hormone in women through an impact on the hypothalamic-pituitary-gonadal axis. They could reduce the levels of follicle stimulating hormone and luteinizing hormone, increase prolactin production, and finally, reduce gonadal steroids. Opioids also could influence thyroid and adrenal glands and subsequently increase thyroid-stimulating hormone, and reduce dehydroepiandrosterone. Eventually, this mechanism caused a disturbance in sexual hormone disturbance in women. Conclusion: Overall, long-term methadone and tramadol consumption as opioid substances could cause sexual hormone disturbance in women.

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Section: Effect Of Methadone On Luteinizing Hormone and Follicle Stim...mentioning

confidence: 95%