Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials

Li, Shaohua; Liu, Xuxia; Bai, Yulong; Wang, Xiaojian; Sun, Kai; Chen, Jingzhou; Hui, Rutai

doi:10.3945/ajcn.2009.28203

Cited by 104 publications

(68 citation statements)

References 45 publications

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“…Cutoff value for FMD was found to be o7% for intervention studies with arginine (Bai et al, 2009). Cutoff for cholesterolemia was found to be 4228 mg/dl (Li et al, 2010), a value compatible with the mild hypercholesterolemia of the present patients (6.4 mmol/l or 247 mg/dl; Table 2). FMD measured at the end of each intervention period did not differ between the HP and LP apples neither did any of the other cardiovascular disease risk factors estimated ( Table 2).…”

Section: Polyphenol-rich Apple and Endothelial Function S Auclair Et Almentioning

confidence: 48%

The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults

et al. 2010

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Background/objectives: Epidemiological studies suggest that apple consumption is associated with a reduction in cardiovascular disease risk. Apple polyphenols may contribute to explain these effects. Endothelial dysfunction has been associated with early stage of atherosclerosis and polyphenols from various dietary sources have been shown to reverse it. The aim of the present study was to investigate the effect of the consumption of a polyphenol-rich apple on endothelial function. Subjects/methods: In all, 30 hypercholesterolemic volunteers were included in a double-blind, randomized crossover trial. They successively consumed 40 g of two lyophilized apples, polyphenol-rich and polyphenol-poor, providing respectively 1.43 and 0.21 g polyphenols per day during two 4-week periods separated by a 4-week washout period. Results: Brachial artery flow-mediated vasodilation (FMD) was assessed at the beginning and at the end of each intervention period. FMD did not differ between the polyphenol-rich and the polyphenol-poor apples, neither did the other cardiovascular disease risk factors (plasma lipids, homocysteine, antioxidant capacity). Conclusions: These data suggest that over a 4-week period, the consumption of a polyphenol-rich apple does not improve vascular function in hypercholesterolemic patients.

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Section: Polyphenol-rich Apple and Endothelial Function S Auclair Et Almentioning

confidence: 48%

The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults

et al. 2010

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“…Soy isoflavones are an important class of flavonoids that include genistein and daidzein, also classified as phytoestrogens, that have been extensively studied for their beneficial effects on endothelial function [138], osteoporosis [139], endometrial hyperplasia [140], cardiovascular system and homocysteine levels [141].…”

Section: Soy Isoflavonesmentioning

confidence: 99%

“…A meta-analysis of 9 RCTs in postmenopausal women, showed that isoflavone improves endothelial function in women with low baseline flow-mediated dilatation (FMD), a marker of endothelial function, but not in women with high baseline FMD levels [138]. Another meta-analysis of RCTs assessing the effects of soy isoflavone supplementation on bone turnover markers in postmenopausal women, revealed that isoflavone moderately decreased urinary deoxypyridinoline (DPD), a bone resorption marker, but did not affect serum bone alkaline phosphatase and serum osteocalcin, 2 bone formation markers [139].…”

Section: Soy Isoflavonesmentioning

confidence: 99%

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Miotto¹,

Striebel²,

Cho

et al. 2013

Drug and Alcohol Dependence

120

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Abstract:Reactive oxygen species (ROS) are widely believed to cause or aggravate several human pathologies such as neurodegenerative diseases, cancer, stroke and many other ailments. Antioxidants are assumed to counteract the harmful effects of ROS and therefore prevent or treat oxidative stress-related diseases. In this report, recent human studies exploring the efficiency of antioxidants in prevention and treatment of various diseases are reviewed. Few antioxidants including edaravone (for ischemic stroke in Japan), Nacetylcysteine (for acetaminophen toxicity), alfa-lipoic acid (for diabetic neuropathy) and some flavonoids (polyphenolic compounds present in dietary plants), such as micronized purified flavonoid fraction (diosmin and hesperidin) and oxerutins (for chronic venous insufficiency) as well as baicalein and catechins (for osteoarthritis) have found accepted clinical use. However, despite much enthusiasm in the 1980s and 1990s, many well-known agents such as antioxidant vitamins and also more recently developed compounds such as nitrones have not successfully passed the scrutiny of clinical trials for prevention and treatment of various diseases. This has given rise to a pessimistic view of antioxidant therapy, however, the evidence from human epidemiological studies about the beneficial effects of dietary antioxidants and preclinical in vitro and animal data are compelling. We have probably wasted too much time on agents like antioxidant vitamins instead of focusing on more disease specific, target-directed, highly bioavailable antioxidants. We here discuss possible reasons for the lack of success in some clinical trials and seek to provide some suggestions to be considered if antioxidant therapy is to succeed as an effective therapeutic strategy.

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“…A placebo-controlled, double-blinded trial of postmenopausal women supplemented with isoflavone soy protein showed no statistically significant effect on atherosclerosis progression [63]. Similarly, a meta-analysis of randomized controlled trials revealed that isoflavone supplementation did not improve endothelial function in postmenopausal women with high baseline flow-mediated dilation levels, but significant benefits were found for those with low baseline flow-mediated levels [64]. A cross-sectional study on middle-aged men in the U.S. reported that usual intake of isoflavones was not associated with a favorable cardiovascular risk profile [65].…”

Section: Discussionmentioning

confidence: 99%

Urinary phytoestrogens and cancer, cardiovascular, and all-cause mortality in the continuous National Health and Nutrition Examination Survey

et al. 2015

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2 AbstractPurpose: Experimental studies suggest that phytoestrogen intake alters cancer and cardiovascular risk. This study investigated the associations of urinary phytoestrogens with total cancer (n=79), cardiovascular (n=108), and allcause (n=290) mortality among 5,179 participants in the continuous National Health and Nutrition Examination Survey (1999Survey ( -2004.Methods: Urinary phytoestrogens were measured using high performance liquid chromatography with tandem mass spectrometric detection. Survival analysis was performed to evaluate hazard ratios (HRs) and 95% confidence intervals (CIs) for each of the three outcomes in relation to urinary phytoestrogens.Results: After adjustment for confounders, higher urinary concentrations of total enterolignans were associated with a reduced risk of death from cardiovascular disease (HR for tertile 3 vs. tertile 1: 0.48; 95% CI: 0.24, 0.97), whereas higher urinary concentrations of total isoflavones (HR for tertile 3 vs. tertile 1: 2.14; 95% CI: 1.03, 4.47) and daidzein (HR for tertile 3 vs. tertile 1: 2.05; 95% CI: 1.02, 4.11) were associated with an increased risk. A reduction in all-cause mortality was observed for elevated urinary concentrations of total enterolignans (HR for tertile 3 vs. Conclusions: Some urinary phytoestrogens were associated with cardiovascular and all-cause mortality in a representative sample of the U.S. population. This is one of the first studies that used urinary phytoestrogens as biomarkers of their dietary intake to evaluate the effect of these bioactive compounds on the risk of death from cancer and cardiovascular disease.

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Effect of oral isoflavone supplementation on vascular endothelial function in postmenopausal women: a meta-analysis of randomized placebo-controlled trials

Abstract: Oral isoflavone supplementation does not improve endothelial function in postmenopausal women with high baseline FMD levels but leads to significant improvement in women with low baseline FMD levels.

Cited by 104 publications

References 45 publications

The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults

The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults

Clinical and pharmacological aspects of bath salt use: A review of the literature and case reports

Urinary phytoestrogens and cancer, cardiovascular, and all-cause mortality in the continuous National Health and Nutrition Examination Survey

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