Effect of oral immunotherapy to peanut on food-specific quality of life

Factor, Jeffrey M.; Mendelson, Louis M.; Lee, Jason; Nouman, Glenda; Lester, Mitchell R.

doi:10.1016/j.anai.2012.08.015

Cited by 96 publications

(76 citation statements)

References 29 publications

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“…This raises the question as to whether reactions with dosing outweigh the benefit gained from therapy, which can only be addressed by an objective evaluation of quality of life influenced specifically by health and disease, or health-related quality of life (HRQL) [14-16]. While single-allergen OIT has been found to result in HRQL improvement in participants with peanut or cow milk allergy [17,18], this study is the first to investigate the effects of mOIT and of rush mOIT with omalizumab on FA-related HRQL.…”

Section: Introductionmentioning

confidence: 99%

Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects

Otani

Bégin

Kearney

et al. 2014

All Asth Clin Immun

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BackgroundFood allergy (FA) negatively affects quality of life in caregivers of food-allergic children, imposing a psychosocial and economic burden. Oral immunotherapy (OIT) is a promising investigational therapy for FA. However, OIT can be a source of anxiety as it carries risk for allergic reactions. The effect of OIT with multiple food allergens (mOIT) on FA-specific health-related quality of life (HRQL) has never been studied in participants with multiple, severe food allergies. This study is the first to investigate the effects of mOIT on FA-related HRQL in caregivers of pediatric subjects.MethodsCaregiver HRQL was assessed using a validated Food Allergy Quality of Life – Parental Burden (FAQL-PB) Questionnaire (J Allergy Clin Immunol 114(5):1159-1163, 2004). Parents of participants in two single-center Phase I clinical trials receiving mOIT (n = 29) or rush mOIT with anti-IgE (omalizumab) pre-treatment (n = 11) completed the FAQL-PB prior to study intervention and at 2 follow-up time-points (6 months and 18 months). Parents of subjects not receiving OIT (control group, n = 10) completed the FAQL-PB for the same time-points.ResultsHRQL improved with clinical (change < -0.5) and statistical (p < 0.05) significance in the mOIT group (baseline mean 3.9, 95% CI 3.4-4.4; 6-month follow-up mean 2.5, 95% CI 2.0-3.0; 18-month follow-up mean 1.8, 95% CI 1.4-2.1) and rush mOIT group (baseline mean 3.9, 95% CI 3.1-4.7; 6-month follow-up mean 1.7, 95% CI 0.9-2.6; 18-month follow-up mean 1.3, 95% CI 0.3-2.4). HRQL scores did not significantly change in the control group (n = 10).ConclusionMulti-allergen OIT with or without omalizumab leads to improvement in caregiver HRQL, suggesting that mOIT can help relieve the psychosocial and economic burden FA imposes on caregivers of food-allergic children.

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Section: Introductionmentioning

confidence: 99%

Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects

Otani

Bégin

Kearney

et al. 2014

All Asth Clin Immun

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“…However, child-reported HRQL scores were significantly improved after OIT. An uncontrolled study of peanut OIT revealed significant improvement in child-and parent-perceived food allergy quality of life questionnaires (FAQLQ) in children 5-12 years of age in all domains including dietary restriction, emotional impact, food-related anxiety, risk of accidental exposure and social limitations [87]. Similar improvements were seen in adolescent quality-of-life scores in all domains except emotional impact of food allergy.…”

Section: Effects On Quality Of Lifementioning

confidence: 57%

Food specific oral immunotherapy: a potential treatment for food allergy

Burbank¹,

Burks

2015

Expert Review of Gastroenterology & Hepatology

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Food allergy is a potentially life-threatening condition affecting up to 8% of children and up to 2% of adults in westernized countries. There are currently no approved treatments for food allergy apart from avoidance. The apparent increase in incidence of food allergies over the past few decades calls attention to the need for effective, disease-modifying therapies for food allergies. Oral immunotherapy (OIT) is a promising experimental treatment in which food allergic patients consume increasing quantities of food in attempt to increase their threshold for allergic reaction. Studies are ongoing to determine whether OIT is capable of safely inducing not only desensitization but also tolerance to the allergenic foods. This article focuses on recent relevant studies of OIT for the treatment of common food allergies.

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“…62 Lastly, in an oral immunotherapy study in a US officeebased practice, the FAQLQ was used (without crosscultural validation) to show that QoL improved with oral immunotherapy. 63 Other QoL Instruments with International Validity (clinic only), moderate correlation with both the PedsQL total and domain-specific scores (clinic sample), strong correlation with the FAQL-PB (self-report), and slight correlation with the FAIM (selfreport). The index discriminated sex differences in samples (QoL worse in females) and number of allergen ( 2 vs !3 foods) in the self-reported sample.…”

Section: Key Findings Using the Faqlq Familymentioning

confidence: 98%

Food Allergy Quality of Life

Greenhawt¹

2014

Annals of Allergy, Asthma & Immunology

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Effect of oral immunotherapy to peanut on food-specific quality of life

Cited by 96 publications

References 29 publications

Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects

Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects

Food specific oral immunotherapy: a potential treatment for food allergy

Food Allergy Quality of Life

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