Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats

Abbas, Mohamed A.; Elmetwally, Samir Atef Farid; Abo-Elfotoh, Mokhtar Ahmed Mokhtar

doi:10.21608/ijma.2020.37970.1152

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…ALP, a hypercritical marker enzyme for the examination of hepatobiliary disorders (Nangia & Yadav, 2021). The possible primary reason for the cytotoxic effect induced by BPA in the liver and kidney is attributed to increased oxidative damage (Abbas et al, 2021). BPA not only trigger the accumulation of reactive oxygen species in hepatic cells, but also decrease the serum levels of enzymatic antioxidants i.e SOD, catalase and GPx (Hassan et al, 2012) related to our results in this study.…”

Section: Discussionsupporting

confidence: 76%

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Management of Bisphenol-A Induced Hepato-Renal Disorder in Wistar Rat by Wheatgrass Aqueous Extract Co-Administration

Barman,

Ghosh,

Kar

et al. 2021

ijbs

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Bisphenol-A (or BPA) is a renowned endocrine disruptor in current use. This study concentrated on the restorative effects of wheatgrass methanolic extract (WG-ME) on the liver and kidney in rats treated with BPA. For this purpose, 18 Wistar rats were divided into 3 groups: Control; BPA (100mg/kg); BPA+ WG-ME (100 mg/kg BPA + 200mg/kg WG-ME) by oral gavage for 28 days study period. Dissected liver and kidney were procured and stored at -20oC for the evaluation of cellular antioxidant status. For the analysis of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea and creatinine levels, which have a role in measuring liver and kidney toxicity, blood samples were collected. In parallel, BPA decreases cellular antioxidant levels super-di-oxide (SOD), catalase and GPx in liver and kidney. The hepato-renal functional tests and antioxidant enzyme levels were significantly improved with the addition of WG-ME oral consumption. These findings provided that protective effect of WG-ME improving BPA-induced metabolic alterations.

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Section: Discussionsupporting

confidence: 76%

“…BPA: 100 mg/kg body weight of BPA dissolved in 1ml of olive oil (Abbas et al, 2021), (Laws et al, 2000. 3.…”

Section: Animals Ethics Statement and Research Designmentioning

confidence: 99%

Management of Bisphenol-A Induced Hepato-Renal Disorder in Wistar Rat by Wheatgrass Aqueous Extract Co-Administration

Barman,

Ghosh,

Kar

et al. 2021

ijbs

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“…The mechanism (Figure -1) by which streptozotocin induces diabetes primarily involves the specific targeting of pancreatic β-cells, leading to their destruction and resultant hyperglycemia. STZ enters [9] the pancreatic β-cells primarily via the glucose transporter GLUT2. GLUT2 has a high affinity for glucose and similar compounds, allowing STZ to be selectively taken up by these cells.…”

Section: A Mechanism Of Streptozotocin Action In β Cells Of the Rat P...mentioning

confidence: 99%

Impact Analysis of Natural Herb on Streptozotocin-Induced Diabetic Rats using Machine Learning Method

Ray,

Susmita

2024

Preprint

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Diabetes mellitus (DM) is a chronic metabolic disorder affecting millions globally. Effective management of DM is crucial to mitigate its complications. Natural herbs, including turmeric (Curcuma longa), aloe vera, and basil (Ocimum basilicum), are known for their medicinal properties and have been explored for their potential benefits in diabetes management. Objective of the paper is to evaluate the impact of the herbal treatment on Fasting Blood Glucose (FBG), Urea, Creatinine levels and Blood Urea Nitrogen (BUN) levels and employ machine learning models to predict and analyze the effectiveness of different doses of the herbal treatment. In this study, we divided our work into two phases. Firstly, we performed the experiment with adult Wistar albino rats and rats were made diabetic through intraperitoneal injection of freshly prepared streptozotocin (STZ). The diabetic rats were split into an untreated control group and treated test groups. The treated groups received varying doses of an aqueous solution of natural herbs (turmeric, aloe vera, and basil) administered orally through gavage for 21 days. In second phase, experimental data were collected and analyzed to detect the impact of natural herbs on diabetic rats. The paper proposes an algorithm that integrates the Bayesian Structural Time Series (BSTS) model with the Dynamic Time Warping (DTW) method. The Bayesian Structural Time Series (BSTS) model has been used as a baseline to determine the impact of natural herbs on specific health metrics such as Fasting Blood Glucose (FBG), Urea, Creatinine, and Blood Urea Nitrogen (BUN) levels. The DTW algorithm has been used in conjunction with the BSTS model to enhance performance. This combination of BSTS and DTW aims to provide a more comprehensive analysis of the effects of natural herbs on the health metrics of diabetic rats, highlighting the potential therapeutic benefits of these herbs in managing diabetes. Significant reduction (p=0.001) in FBG levels, Urea, Creatinine and BUN levels indicates the potential of this herbal combination in managing blood sugar levels. These findings suggest that the combined herbal preparation has a beneficial effect on the treatment of diabetes mellitus.

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“…BPA is cytotoxic and mutagenic in aquatic organisms, animals, and humans. BPA exposure is known to cause various adverse effects on the immune, endocrine, reproductive, developmental and nervous systems [ 131 , 132 ].…”

Section: Bisphenol Amentioning

confidence: 99%

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Zhang

Flaws

Spinella

et al. 2022

Toxics

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Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.

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Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats

Cited by 3 publications

References 7 publications

Management of Bisphenol-A Induced Hepato-Renal Disorder in Wistar Rat by Wheatgrass Aqueous Extract Co-Administration

Management of Bisphenol-A Induced Hepato-Renal Disorder in Wistar Rat by Wheatgrass Aqueous Extract Co-Administration

Impact Analysis of Natural Herb on Streptozotocin-Induced Diabetic Rats using Machine Learning Method

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

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