Effect of oral exercises and photobiomodulation therapy in the rehabilitation of patients with mandible fractures: randomized double-blind clinical trial

Santos, Karoline Weber dos; Hugo, Fernando Neves; Rodrigues, Esther da Cunha; Stein, Airton Tetelbom; Hilgert, Juliana Balbinot

doi:10.1007/s10103-021-03423-w

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…Phototherapy has the advantages of less trauma, high biocompatibility and fast response speed compared with traditional therapeutic strategies. 15 , 16 NIR device has been applied to treat alopecia, myopia and dermatosis with good efficacy in clinical practice. 17 Unlike high-intensity (10-80 W·cm −2 ) and moderate-intensity (up to 1 W/cm 2 ) light, mainly used for cauterization and cutting in clinics, low-intensity NIR light (usually below 50 mW·cm −2 ) generally does not cause irreversible damage to biological tissues, but only induces biological responses, promoting the recovery of tissue structures and functions.…”

Section: Introductionmentioning

confidence: 99%

Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1

et al. 2022

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Bone regeneration remains a great clinical challenge. Low intensity near-infrared (NIR) light showed strong potential to promote tissue regeneration, offering a promising strategy for bone defect regeneration. However, the effect and underlying mechanism of NIR on bone regeneration remain unclear. We demonstrated that bone regeneration in the rat skull defect model was significantly accelerated with low-intensity NIR stimulation. In vitro studies showed that NIR stimulation could promote the osteoblast differentiation in bone mesenchymal stem cells (BMSCs) and MC3T3-E1 cells, which was associated with increased ubiquitination of the core circadian clock protein Cryptochrome 1 (CRY1) in the nucleus. We found that the reduction of CRY1 induced by NIR light activated the bone morphogenetic protein (BMP) signaling pathways, promoting SMAD1/5/9 phosphorylation and increasing the expression levels of Runx2 and Osterix. NIR light treatment may act through sodium voltage-gated channel Scn4a, which may be a potential responder of NIR light to accelerate bone regeneration. Together, these findings suggest that low-intensity NIR light may promote in situ bone regeneration in a CRY1-dependent manner, providing a novel, efficient and non-invasive strategy to promote bone regeneration for clinical bone defects.

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Section: Introductionmentioning

confidence: 99%

Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1

et al. 2022

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The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

Alam,

Karami,

Mohammadikhah

et al. 2024

Cell Biochemistry & Function

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The use of photobiomodulation therapy (PBMT) may be used for treating trauma to the maxillofacial region. The effects of PBMT on maxillofacial injuries were discussed in this review article. The electronic databases Pubmed, Scopus, and Web of Science were thoroughly searched. This review included in vitro, in vivo, and clinical studies describing how PBMT can be used in maxillofacial tissue engineering and regenerative medicine. Some studies suggest that PBMT may offer a promising therapy for traumatic maxillofacial injuries because it can stimulate the differentiation and proliferation of various cells, including dental pulp cells and mesenchymal stem cells, enhancing bone regeneration and osseointegration. PBMT reduces pain and swelling after oral surgery and tooth extraction in human and animal models of maxillofacial injuries. Patients with temporomandibular disorders also benefit from PBMT in terms of reduced inflammation and symptoms. PBMT still has some limitations, such as the need for standardizing parameters. PBMT must also be evaluated further in randomized controlled trials in various maxillofacial injuries. As a result, PBMT offers a safe and noninvasive treatment option for patients suffering from traumatic maxillofacial injuries. PBMT still requires further research to establish its efficacy in clinical practice and determine the optimal parameters.

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Effectiveness of photobiomodulation and orofacial myofunctional therapy in orofacial pain disorders. A systematic review of randomized control trials

Altuhafy,

Ahmed,

Jabr

et al. 2024

Lasers Med Sci

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Effect of oral exercises and photobiomodulation therapy in the rehabilitation of patients with mandible fractures: randomized double-blind clinical trial

Cited by 5 publications

References 25 publications

Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1

Low intensity near-infrared light promotes bone regeneration via circadian clock protein cryptochrome 1

The effect of photobiomodulation therapy in common maxillofacial injuries: Current status

Effectiveness of photobiomodulation and orofacial myofunctional therapy in orofacial pain disorders. A systematic review of randomized control trials

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