Effect of oral ethanol intake on muscle sympathetic nerve activity and cardiovascular functions in humans

Iwase, Satoshi; Matsukawa, Tetsuya; Ishihara, Sawako; Tanaka, Atsushi; Tanabe, Kengo; Danbara, Atsushi; Matsuo, Masaki; Sugiyama, Yoshiki; Mano, Tadaaki

doi:10.1016/0165-1838(95)00022-p

Cited by 40 publications

(38 citation statements)

References 27 publications

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“…It is well established that intoxicating doses of alcohol increase heart rate (Docter et al 1966;Iwase et al 1995 McCaul et al 1989;Sellers et al 1972;Turkkan et al 1988;van de Borne et al 1997). These heart rate increases are hypothesized to be positively associated with the reinforcing or appetitive motivational effects of alcohol (Peterson et al 1996) .…”

Section: Alcohol Ingestion Activates the Autonomic Nervous System Andmentioning

confidence: 99%

“…These heart rate increases are hypothesized to be positively associated with the reinforcing or appetitive motivational effects of alcohol (Peterson et al 1996) . Alcohol has less predictable effects on blood pressure, with reports of blood pressure increases (Iwase et al 1995;Sellers et al 1972) and no effects following alcohol ingestion (Turkkan et al 1988;van de Borne et al 1997). Finally, alcoholinduced peripheral vasodilation and associated skin temperature increases have been consistently reported (Iwase et al 1995;Turkkan et al 1988) and is thought to be one explanation for the lack of a consistent rise in blood pressure after alcohol consumption.…”

Section: Alcohol Ingestion Activates the Autonomic Nervous System Andmentioning

confidence: 99%

“…Alcohol has less predictable effects on blood pressure, with reports of blood pressure increases (Iwase et al 1995;Sellers et al 1972) and no effects following alcohol ingestion (Turkkan et al 1988;van de Borne et al 1997). Finally, alcoholinduced peripheral vasodilation and associated skin temperature increases have been consistently reported (Iwase et al 1995;Turkkan et al 1988) and is thought to be one explanation for the lack of a consistent rise in blood pressure after alcohol consumption.Acute administration of intoxicating doses of alcohol also activates the hypothalamic-pituitary-adrenal (HPA) axis thereby increasing ACTH and glucocorticoid levels (Inder et al 1995;Rivier et al 1984;Waltman et al 1993). It remains unclear whether alcohol-induced activation of the HPA axis has any relationship to its reinforcing properties.…”

mentioning

confidence: 99%

“…It is well established that intoxicating doses of alcohol increase heart rate (Docter et al 1966;Iwase et al 1995;N EUROPSYCHOPHARMACOLOGY 2001 -VOL . 25 , NO .…”

mentioning

confidence: 99%

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Naltrexone Dampens Ethanol-Induced Cardiovascular and Hypothalamic- Pituitary-Adrenal Axis Activation

McCaul

2001

Neuropsychopharmacology

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Alcohol ingestion activates the autonomic nervous system and the hypothalamic-pituitary-adrenal axis. This study examined naltrexone effects on alcohol-induced increases in physiological responses and their association with alcohol liking. Using a within-subjects design, heavy drinking men (N ϭ 19) were maintained on each of three naltrexone doses (0, 50, and 100 mg, p.o.) over an 8-day inpatient stay. Within each naltrexone dose, subjects had three alcohol challenge sessions (none, moderate, high) The brain opioid system has been proposed to be part of the neurocircuitry involved in alcohol reward and heavy alcohol drinking (Froehlich and Wand 1997;Gianoulakis and deWaele 1994;Reid et al. 1991). Pharmacological studies indicate that opioid receptor antagonists, such as naloxone hydrochloride and naltrexone, decrease alcohol self-administration in animal models (Altshuler et al. 1980;Froehlich et al. 1990;Hubbell et al. 1986Hubbell et al. , 1991Marfaing-Jallat et al. 1983;Samson and Doyle 1985;Weiss et al. 1990). Clinical trials demonstrated that naltrexone reduces alcohol drinking and self-reported "high," alcohol craving, as well as relapse rates in recently abstinent outpatient alcohol-dependent patients (O'Malley et al. 1992;Volpicelli et al. 1992Volpicelli et al. , 1995 . These findings led to naltrexone's approval by the Food and Drug Administration as a pharmacotherapeutic agent for the treatment of alcohol dependence. Naltrexone is thought to reduce alcohol-induced high and relapse by binding to opioid receptors in discrete brain regions associated with reward and craving, and to prevent receptor activation by alcohol-induced release of endogenous opioid peptides.Alcohol induces a variety of acute physiological responses when consumed in moderate-to-high doses. It is well established that intoxicating doses of alcohol increase heart rate (Docter et al. 1966;Iwase et al. 1995 McCaul et al. 1989;Sellers et al. 1972;Turkkan et al. 1988;van de Borne et al. 1997). These heart rate increases are hypothesized to be positively associated with the reinforcing or appetitive motivational effects of alcohol (Peterson et al. 1996) . Alcohol has less predictable effects on blood pressure, with reports of blood pressure increases (Iwase et al. 1995;Sellers et al. 1972) and no effects following alcohol ingestion (Turkkan et al. 1988;van de Borne et al. 1997). Finally, alcoholinduced peripheral vasodilation and associated skin temperature increases have been consistently reported (Iwase et al. 1995;Turkkan et al. 1988) and is thought to be one explanation for the lack of a consistent rise in blood pressure after alcohol consumption.Acute administration of intoxicating doses of alcohol also activates the hypothalamic-pituitary-adrenal (HPA) axis thereby increasing ACTH and glucocorticoid levels (Inder et al. 1995;Rivier et al. 1984;Waltman et al. 1993). It remains unclear whether alcohol-induced activation of the HPA axis has any relationship to its reinforcing properties. Rodent studies show that alcohol increases pla...

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Section: Alcohol Ingestion Activates the Autonomic Nervous System Andmentioning

confidence: 99%

Section: Alcohol Ingestion Activates the Autonomic Nervous System Andmentioning

confidence: 99%

mentioning

confidence: 99%

“…It is well established that intoxicating doses of alcohol increase heart rate (Docter et al 1966;Iwase et al 1995;N EUROPSYCHOPHARMACOLOGY 2001 -VOL . 25 , NO .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Naltrexone Dampens Ethanol-Induced Cardiovascular and Hypothalamic- Pituitary-Adrenal Axis Activation

McCaul

2001

Neuropsychopharmacology

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“…Ethanol may reduce vasodilation mediated by endothelium in rat mesenteric capillaries 43 . On the other hand, in humans the acute vasodilating effect of alcohol is associated with a reduction in peripheral resistance 44 . The hemodynamic effects of wine may be secondary to antioxidant effects 45,46 , induction of the sythesis of nitric oxide 47 , and endothelium-mediated vasodilation 45 , in addition to its effects on platelet aggregation 48 , and plasminogen activation 49,50 .…”

Section: Effects Of Alcohol On Cardiovascular Risk Factorsmentioning

confidence: 99%

Alcohol and atherosclerosis

Foppa

Fuchs²,

Duncan³

2001

Arq. Bras. Cardiol.

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Observational studies have attributed a protective effect to alcohol consumption on the development of atherosclerosis and cardiovascular morbidity and mortality. Alcohol intake in the amount of one to two drinks per day results in an estimated 20-40% reduction in cardiovascular events. An additional protective effect, according to major cohort studies, has been attributed to wine, probably due to antioxidant effects and platelet antiaggregation agents. On the other hand, the influence of different patterns of alcohol consumption and environmental factors may explain a great part of the additional effect of wine. Protection may be mediated by modulation of other risk factors, because alcohol increases HDL-C, produces a biphasic response on blood pressure, and modulates the endothelial function, while it neither increases body weight nor impairs glucose-insulin homeostasis. Alcohol may also have a direct effect on atherogenesis. Despite these favorable effects, the current evidence is not enough to justify prescribing alcohol to prevent cardiovascular disease

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Comparison of the influence of alcohol and cannabis on the dynamics of the accommodative response

Casares-López

Ortiz-Peregrina

Ortíz

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Effect of oral ethanol intake on muscle sympathetic nerve activity and cardiovascular functions in humans

Cited by 40 publications

References 27 publications

Naltrexone Dampens Ethanol-Induced Cardiovascular and Hypothalamic- Pituitary-Adrenal Axis Activation

Naltrexone Dampens Ethanol-Induced Cardiovascular and Hypothalamic- Pituitary-Adrenal Axis Activation

Alcohol and atherosclerosis

Comparison of the influence of alcohol and cannabis on the dynamics of the accommodative response

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