Effect of Oral Drenching with Zinc Oxide or Synthetic Zeolite A on Total Blood Calcium in Dairy Cows

Jørgensen, R. J.; Hansen, T.L.; Jensen, Mary Lee; Thilsing-Hansen, T.

doi:10.3168/jds.s0022-0302(01)74514-6

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…However, recent studies attempt to revive the low calcium principle by introducing induced reduced ration calcium availability by the addition of a calcium binder to the ration [64,109,63,110,119]. …”

Section: Low Calcium Intake and Low Ca/p In Late Pregnancymentioning

confidence: 99%

Milk Fever Control Principles: A Review

Thilsing-Hansen¹,

Jørgensen²,

Østergaard³

2002

Acta Vet Scand

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Thilsing-Hansen T, Jørgensen RJ, Østergaard S: Milk fever control principles: A review. Acta vet. scand. 2002, 43, 1-19. -Three main preventive principles against milk fever were evaluated in this literature review, and the efficacy of each principle was estimated from the results of controlled investigations. Oral calcium drenching around calving apparently has a mean efficacy of 50%-60% in terms of milk fever prevention as well as prevention of milk fever relapse after intravenous treatment with calcium solutions. However, some drenches have been shown to cause lesions in the forestomacs. When using the DCAD (dietary cation-anion difference) principle, feeding rations with a negative DCAD (measured as (Na + K) -(Cl + S)) significantly reduce the milk fever incidence. Calculating the relative risk (RR) of developing milk fever from controlled experiments results in a mean RR between 0.19 and 0.35 when rations with a negative versus positive DCAD are compared. The main drawback from the DCAD principle is a palatability problem. The principle of feeding rations low in calcium is highly efficient in milk fever prevention provided the calcium intake in the dry period is kept below 20 g per day. Calculating the relative risk (RR) of developing milk fever from controlled experiments results in a very low mean RR (between 0 and 0.20) (daily calcium intake below versus above 20 g/d). The main problem in implementing the low-Ca principle is difficulties in formulating rations sufficiently low in calcium when using commonly available feeds. The use of large doses of vitamin D metabolites and analogues for milk fever prevention is controversial. Due to toxicity problems and an almost total lack of recent studies on the subject this principle is not described in detail. A few management related issues were discussed briefly, and the following conclusions were made: It is important to supply the periparturient cow with sufficient magnesium to fulfil its needs, and to prevent the dry cows from being too fat. Available information on the influence of carbohydrate intake, and on the effect of the length of the dry period and prepartum milking, is at present insufficient to include these factors in control programmes. dairy cows; parturient hypocalcaemia; milk fever prevention.

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Section: Low Calcium Intake and Low Ca/p In Late Pregnancymentioning

confidence: 99%

Milk Fever Control Principles: A Review

Thilsing-Hansen¹,

Jørgensen²,

Østergaard³

2002

Acta Vet Scand

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“…These compounds improve animal health via different modes of action, such as decreasing the proinflammatory NF-κB signaling, scavenging free radicals or inhibiting their formation, and regulating antioxidant enzymes expression, e.g., upregulation of superoxide dismutase in mitochondria (16). The application of clay mineral-based feed additives was previously discussed to decrease the bioavailability of Ca and other minerals by means of cation adsorption (41). Our findings on serum magnesium, inorganic phosphorus, and calcium concentrations, however, do not support this assumption, as all mineral concentrations were within the respective physiological ranges for dairy cows (42,43).…”

Section: Discussionmentioning

confidence: 99%

Supplementing a Clay Mineral-Based Feed Additive Modulated Fecal Microbiota Composition, Liver Health, and Lipid Serum Metabolome in Dairy Cows Fed Starch-Rich Diets

et al. 2021

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Starch-rich diets are a commonly adopted strategy in order to sustain high milk yields in dairy cows. However, these diets are known to increase the risk of gut dysbiosis and related systemic health disorders. This study aimed to evaluate the effects of supplementing a clay mineral-based feed additive (CM; Mycofix® Plus, BIOMIN) on fecal microbiota structure, fecal short-chain fatty acid (SCFA) fermentation, serum metabolome, and liver health in primiparous (PP, n = 8) and multiparous (MP, n = 16) early-lactation Simmental cows (737 ± 90 kg of live body weight). Cows were randomly assigned to either a control or CM group (55 g per cow and day) and transitioned from a diet moderate in starch (26.3 ± 1.0%) to a high starch diet (32.0 ± 0.8%). Supplementation of CM reversed the decrease in bacterial diversity, richness, and evenness (p < 0.05) during high-starch diet, demonstrating that CM supplementation efficiently eased hindgut dysbiosis. The CM treatment reduced levels of Lactobacillus in PP cows during starch-rich feeding and elevated fecal pH, indicating a healthier hindgut milieu compared with that in control. Butyrate and propionate levels were modulated by CM supplementation, with butyrate being lower in CM-treated MP cows, whereas propionate was lower in MP but higher in PP cows. Supplementing CM during high-starch feeding increased the concentrations of the main primary bile salts and secondary bile acids in the serum and improved liver function in cows as indicated by reduced levels of glutamate dehydrogenase and γ-glutamyl-transferase, as well as higher serum albumin and triglyceride concentrations. These changes and those related to lipid serum metabolome were more pronounced in PP cows as also corroborated by relevance network analysis.

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“…Subclinical hypocalcemia has been documented in up to 50% of periparturient dairy cows [ The intake of key minerals like zinc (Zn) was balanced, which improved immunological function and reduced the occurrence of health concerns like milk fever. Cows are reported to be predisposed to milk fever depending on their age, milk output, breed, body condition, dry period length, and feeding [8]. Zn is needed in small amounts but absolutely must be in the feed, because Zn cannot be converted from other nutrients.…”

Section: Introductionmentioning

confidence: 99%

“…Zn is needed in small amounts but absolutely must be in the feed, because Zn cannot be converted from other nutrients. This mineral plays a role in a variety of enzyme activities, cell growth and differentiation, and plays an important role in optimizing the function of the immune system [8]. Zn is able to act as an immune stimulator that is able to increase the immune system.…”

Section: Introductionmentioning

confidence: 99%

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Prepartum Zinc Supplementation in Dairy Cows and Its Effect on Plasma Calcium, Titers Antibodies and Milk Zinc Content in Postpartum Dairy Cow

Mayasari¹,

Afriandana²,

Setyowati³

et al. 2022

Advances in Biological Sciences Research

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The plane of energy nutrient and supplementation of mineral fed to cows in the prepartum period has been shown to influence energy status, immune response, and metabolic health. However, the effect of supplementation of essential mineral like Zn in the diet on plasma titers antibodies and mineral status in postpartum dairy cows is less known. This study investigated the effect of prepartum Zn supplementation in dairy cows on calcium (Ca) status, titer antibodies in plasma and milk Zn content in dairy cows at week 1 after calving. Lipopolysaccharide (LPS) were used as an antigen. Twenty dairy cows (FH) were randomly assigned to 2 groups: dry cow basal diet (control group; CON) and basal diet with supplementation of Zn 40 ppm (CON+Zn). Both Ca in plasma and Zn milk content were determined by atomic absorption spectrophotometry. Blood and milk sample were taken at week 1 after calving. Results showed there were no significant differences on Ca plasma, titers antibodies (IgG and IgM) and milk Zn among dietary treatments. Numerically, plasma Ca, milk Zn content and IgG binding LPS were higher in cows fed Zn supplementation compared with control group. No significant differences in the status of Ca and Zn and titers IgG binding LPS at week 1 after calving were observed between the 2 groups maybe due to high immune status of these cows. It seems feeding Zn above the requirements before calving maintain immune status, better milk nutrient dense and reduce the incidence of milk fever.

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Effect of Oral Drenching with Zinc Oxide or Synthetic Zeolite A on Total Blood Calcium in Dairy Cows

Cited by 11 publications

References 12 publications

Milk Fever Control Principles: A Review

Milk Fever Control Principles: A Review

Supplementing a Clay Mineral-Based Feed Additive Modulated Fecal Microbiota Composition, Liver Health, and Lipid Serum Metabolome in Dairy Cows Fed Starch-Rich Diets

Prepartum Zinc Supplementation in Dairy Cows and Its Effect on Plasma Calcium, Titers Antibodies and Milk Zinc Content in Postpartum Dairy Cow

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