Effect of oral d-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats

Nikeghbalian, Saman; Atefi, Sohrab; Kazemi, Kourosh; Roshan, Naghmeh; Tanideh, Nader; Jalaeian, Hamed

doi:10.1016/j.fertnstert.2007.01.109

Cited by 2 publications

(3 citation statements)

References 12 publications

(8 reference statements)

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“…It can also attenuate immune reaction and decrease blood disk effusion and fibrin deposition by inhibiting generation of IgG and IgM and decreasing antigen-antibody complex in blood-serum, which blocks the first stage of abdominal adhesions. It is reported that D-penicillamine administration markedly reduces severe adhesions band formation without severe side effects [18]. Therefore, we hypothesized, based on these results, that a combination of penicillamine and barrier products may be a better treatment for adhesions.…”

Section: Discussionmentioning

confidence: 89%

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Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions

Zhang

et al. 2011

BMC Surg

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BackgroundAdhesions formation is a significant postsurgical complication. At present, there is no effective method for preventing adhesions formation [1], although barrier products such as Dextran (Dex) [2] and sodium hyaluronate (SH) [3] have proved the most clinically successful [4-6], This study is designed to investigate the preventive and therapeutic potential of a novel penicillamine-bound membrane for abdominal adhesions formation.Methods150 rats were involved in the present study. All animals were randomly divided into 6 groups (1 vehicle group and 5 test groups respectively treated with dextran, sodium hyaluronate, penicillamine, penicillamine-bound membrane or non-penicillamine-bound membrane). The occurrence, grade and score of abdominal adhesions were compared between the different groups. The breaking strength of incision was compared between the vehicle group and the penicillamine, membrane with/without penicillamine - treated groups. Expression of collagen type I was compared between the vehicle and penicillamine-treated group. The occurrence of adhesions was compared between the Dextran (Dex), sodium hyaluronate (SH), penicillamine-treated group and membrane with or without penicillamine- treated groups.ResultsPenicillamine and penicillamine-bound membrane had significant preventive effects on abdominal adhesions formation, better than dextran, sodium hyaluronate and non-penicillamine-bound membrane. However, neither of them influenced incision healing, although they insignificantly decreased the breaking strength of the incision. Penicillamine-bound membrane, which can be loaded locally and more efficaciously, shows greater advantages than penicillamine.ConclusionsPenicillamine-bound membrane can be applied as an effective therapeutic intervention for abdominal adhesions with inconsequential side effects.

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Section: Discussionmentioning

confidence: 89%

“…Recent studies indicated the possibility of oral D-penicillamine-induced prevention on peritoneal adhesions band formation [16-18]. We therefore hypothesized that it can prevent the fibrin from converting into permanent fiber adhesions tissue.…”

Section: Introductionmentioning

confidence: 98%

Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions

Zhang

et al. 2011

BMC Surg

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“…In some recent studies, it was mentioned that prednisolone and CellCept are used above usual dosage and the results were compared to each other. Various strategies have been devised to reduce the incidence of peritoneal adhesions; nonetheless, partial achievement has been gained up to now [33]. One of them was removal of fibrinous exudates by peritoneal lavage [34,35].…”

Section: Discussionmentioning

confidence: 99%

Reduction of peritoneal adhesion bands by mycophenolate mofetil (CellCept) and prednisolone in rats

Sanei¹,

Shariati²,

Zare³

et al. 2014

Int J Hepatobiliary Pancreat Dis

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Aims: the purpose of this study was to assess the efficacy of prednisolone and cellcept in decreasing postoperative adhesion band formation in rats. Methods: sixty male rats were randomly divided into three equal groups. A standard midline incision was made on the abdomen of each rat, then 2 mL of 10% sterile solution talc was injected into intraperitoneal cavity in order to induce adhesion. Group 1 served as control group, while group 2 received oral cellcept (40 mg/kg/d) and group 3 received oral Prednisolone (5 mg/kg/d) for 4 weeks. results: the formation of adhesion bands in control group was significantly higher than the prednisolone and cellcept group (p <0.001). the amount of adhesion bands in the second group was similar to the third one. conclusion: Orally administered cellcept is as effective as oral prednisolone in declining chance of intraperitoneal adhesion band formation, although it causes fewer complications such as infection in rats.

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Effect of oral d-penicillamine vs. colchicine on experimentally induced peritoneal adhesions in rats

Cited by 2 publications

References 12 publications

Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions

Administration of a novel penicillamine-bound membrane: a preventive and therapeutic treatment for abdominal adhesions

Reduction of peritoneal adhesion bands by mycophenolate mofetil (CellCept) and prednisolone in rats

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