Effect of oral administration of Lactobacillus casei on alloxan‐induced diabetes in mice

Abstract

Yokokura, T. Effect of oral administration of Lactobacillus casei on alloxan-induced diabetes in mice. APMIS 105: [637][638][639][640][641][642] 1997.The effects of Lactobacillus casei (LC) on the onset of alloxan (AXN)-induced diabetes in 7-week-old BALBic mice were examined. It was observed that the mice given a diet containing 0.1%1 or 0.05% LC or orally administered LC showed significantly decreased incidence of diabetes induced by intravenous injection of AXN and that the plasma glucose level was slightly lower than that in the control group.The body weight in the LC-treated groups was higher than that in the control group, although the food intake weights were almost the same. Pathological analysis revealed that the XXN-induced disappearance of insulin-secreting p-cells in the islets of Langerhans was strongly inhibited in the LCtreated groups. It was also shown that the serum nitric oxide level was maintained at a normal level in LC-treated mice, whereas the level in the control group was increased by AXN administration. Taken together, these findings suggest that oral administration of LC to AXN-treated BALBic mice contributed to the reduction of diabetes and the increase in plasma glucose level.

Probiotics: Immunomodulation and Evaluation of Safety and Efficacy

“…The effects of L. casei Shirota have been studied in two experimental models of insulin-dependent diabetes mellitus: alloxan-induced diabetes and non-obese diabetic (NOD) mice. 36,37 In both models, L. casei Shirota decreased the incidence of diabetes, slightly reduced plasma glucose levels, and prevented the destruction of the ␤-cells and islets of Langerhans. In the alloxan model, destruction of ␤-cells was caused by nitric oxide.…”

Potential mechanisms linking probiotics to diabetes: a narrative review of the literature

“…• using glucose as a source of nutrition or by controlling the intestinal flora balance and through similar activity such as indigestible fiber, thus affecting glucose absorption • suppressing oxidative stress Matsuzaki et al 37 Experimental study.…”

“…37,44 On the other hand, foods containing probiotics have been shown to protect against indices relating to diabetes. In one study, probiotic yogurt consumption increased the activity levels of erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx), which scavenge free radicals, and improved the total antioxidant status (TAS).…”

Probiotics Applications in Autoimmune Diseases

“…Treatment with Bifidobacteria and Lactobacilli has been shown to normalize the composition of the gut flora in children with T1D [131,138]. In addition, the administration of Lactobacilli to alloxan-induced diabetic mice prolonged their survival [139,140] and administration to non-obese diabetic (NOD, a rodent model of T1D) mice inhibited diabetes development possibly by the regulation of the host immune response and reduction of nitric oxide production [140]. Furthermore, the administration of a mixture of Bifidobacteria, Lactobacilli and Streptococci to NOD mice was protective against T1D development postulated to be through induction of interleukins IL4 and IL10 [141].…”