Effect of Optic Disc Size and Disease Severity on the Diagnostic Capability of Glaucoma Imaging Technologies in an Indian Population

Garudadri, Chandra S.; Rao, Harsha L.; Parikh, Rajul; Jonnadula, Ganesh Babu; Selvaraj, Prabhakaran; Nutheti, Rishita; Thomas, Ravi

doi:10.1097/ijg.0b013e31821829f1

Cited by 13 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[10][11][12][13][14] These studies, however, included glaucoma patients with all severities of visual field damage that might have biased the results, as the estimates of diagnostic accuracy are known to improve with the severity of disease. [15][16][17] In clinical practice, the challenge is to diagnose glaucoma in early stages and there is limited literature on the diagnostic ability of SD-OCT in early glaucoma. 17,18 The purpose of the present study was to compare the diagnostic accuracies of the RNFL and MIR measurements obtained with SD-OCT in early glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma

Rao

Jonnadula

Addepalli

et al. 2011

Eye

View full text Add to dashboard Cite

Purpose To compare the diagnostic abilities of peripapillary retinal nerve fiber layer (RNFL) and macular inner retina (MIR) measurements by spectral domain optical coherence tomography (SD-OCT) in Indian eyes early glaucoma. Methods In an observational, cross-sectional study, 125 eyes of 64 normal subjects and 91 eyes of 59 early glaucoma patients underwent RNFL and MIR imaging with SD-OCT. Glaucomatous eyes had characteristic optic nerve and RNFL abnormalities and correlating visual field defects and a mean deviation of better than or equal to -6 dB on standard automated perimetry. Areas under the receiver operating characteristic curves (AUC), sensitivities at a fixed specificity and likelihood ratios (LRs) were estimated for all RNFL and MIR parameters. Results The AUCs for the RNFL parameters ranged from 0.537 for the temporal quadrant thickness to 0.821 for the inferior quadrant RNFL thickness. AUCs for the MIR parameters ranged from 0.603 for the superior minus inferior MIR thickness average to 0.908 for ganglion cell complex focal loss volume (GCC-FLV). AUC for the best MIR parameter (GCC-FLV) was significantly better (Po0.001) than that of the best RNFL parameter (inferior quadrant thickness). The sensitivities of these parameters at high specificity of 95%, however, were comparable (52.7% vs 58.2%). Evaluation of the LRs showed that outside normal limits results of most of the RNFL and MIR parameters were associated with large effects on the post-test probability of disease. Conclusion MIR parameters with RTVue SD-OCT were as good as the RNFL parameters to detect early glaucoma.

show abstract

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma

Rao

Jonnadula

Addepalli

et al. 2011

Eye

View full text Add to dashboard Cite

show abstract

“…This is similar to the relationship reported between sensitivity to diagnose glaucoma and the severity of glaucomatous VF damage, using various imaging techniques. [31][32][33][34][35] However, as noted in Figure 2, the sensitivities with SDOCT appeared to be better than those with GDx ECC in the early stages of glaucoma. Future studies are required to evaluate whether SDOCT is better than SLP in early (and preperimetric) stages of glaucoma.…”

Section: Discussionmentioning

confidence: 85%

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Rao

Yadav

Addepalli

et al. 2014

Eye

View full text Add to dashboard Cite

Purpose To compare the abilities of retinal nerve fiber layer (RNFL) parameters of spectral domain optical coherence tomograph (SDOCT) and scanning laser polarimeter (GDx enhanced corneal compensation; ECC) in detecting glaucoma. Methods In a cross-sectional study, 215 eyes of 165 subjects (106 eyes of 79 glaucoma patients and 109 eyes of 86 controls) referred by general ophthalmologists for glaucoma evaluation underwent RNFL imaging with SDOCT and GDx ECC. Ability of RNFL parameters of SDOCT to discriminate glaucoma eyes from control eyes was compared with that of GDx ECC using area under operating characteristic curves (AUCs), sensitivities at fixed specificities, and likelihood ratios (LRs). Results AUC of the average RNFL thickness of SDOCT to differentiate glaucoma from control eyes (0.868) was comparable (P ¼ 0.32) to that of GDx ECC (0.855). Sensitivity at 95% specificity was 63.2% for average RNFL thickness of SDOCT and 48.1% for the average RNFL measurement of GDx ECC. LRs of outside normal limits category of SDOCT parameters ranged between 5.6 and 7.7 while the same of GDx ECC parameters ranged between 3.1 and 3.7. LRs of within normal limits category of SDOCT parameters ranged between 0.18 and 0.24 while the same of GDx ECC parameters ranged between 0.20 and 0.32. Conclusion Though AUCs and sensitivities at fixed specificities were comparable between the RNFL parameters of SDOCT and GDx ECC in diagnosing glaucoma, LRs indicated that the RNFL parameters of SDOCT were better in 'ruling in' glaucoma.

show abstract

“…Lee et al [17] found that the best performing parameter for glaucoma detection of the GDx is the nerve fiber index and that for Cirrus OCT the inferior RNFL thickness. GDx was also more accurate in detecting glaucoma than the Cirrus OCT. Two recent studies [18,19] showed that the diagnostic accuracy for glaucoma of the HRT II is dependent on the disc size which is not the case for OCT and GDx.…”

Section: Sensitivity and Specificitymentioning

confidence: 98%

Recognizing a Glaucomatous Optic Disc

Kozobolis¹,

Konstantinidis²,

Labiris³

2013

Glaucoma - Basic and Clinical Aspects

View full text Add to dashboard Cite

Effect of Optic Disc Size and Disease Severity on the Diagnostic Capability of Glaucoma Imaging Technologies in an Indian Population

Abstract: Optic disc size affects the diagnostic capability of HRT II but not that of GDx VCC or Stratus OCT. The sensitivity of all 3 imaging technologies increased with increasing disease severity.

Cited by 13 publications

References 22 publications

Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma

Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma

Retinal nerve fiber layer evaluation of spectral domain optical coherence tomograph and scanning laser polarimeter to diagnose glaucoma

Recognizing a Glaucomatous Optic Disc

Contact Info

Product

Resources

About