Effect of Opioids on Survival in Patients with Cancer

Boland, Jason W

doi:10.3390/cancers14225720

Cited by 12 publications

(3 citation statements)

References 61 publications

(141 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Opioids may have fewer side effects when administered under analgesic ladder therapy guidance; however, opioid therapy may entail gastrointestinal symptoms such as nausea, vomiting, and constipation, as well as central effects ranging from sedation to unconsciousness and respiratory depression. These risks are particularly notable when considering the overall disease course of cancer and the similar adverse effects associated with chemotherapy and radiotherapy [15]. Adjuvant agents such as pregabalin, gabapentin, and duloxetine can be used to treat patients with cancer-related neuropathic pain or in cases of inadequate current treatment [16].…”

Section: Discussionmentioning

confidence: 99%

Prolonged Effect of Repetitive Erector Spinae Plane Block in Reducing Thoracic Pain Caused by Lung Cancer

Tanyel Saraçoğlu,

Akbaş,

Onay

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction: Pain significantly affects the quality of life of lung cancer patients. We aimed to evaluate the effect of the erector spinae plane block (ESPB) on pain in these patients.Methods: We reviewed the medical records of patients with primary lung and bronchial cancer who experienced refractory pain in the thoracic region and underwent repeated ESPBs (three blocks at 24-hour intervals) between 2019 and 2020 in this single-center retrospective study. Visual analog scale (VAS) scores recorded before the procedure and on the first day (first day after the third block) and the first and third months of follow-up in 43 patients were analyzed. Results:The study population consisted of 31 male and 12 female patients, with a mean age of 56.7 years. The mean pre-procedure VAS score was 8.9±0.8, which showed a significant decrease on the first day (2.9), first month (3.6), and third month (4.6) of the follow-up. Four patients experienced minor complications (pain at the procedure site and hypotension); however, no major complications were observed. Conclusion:We observed a prolonged effect of repeated ESPBs for ≥3 months. The block efficacy decreased with time; however, an approximately 50% reduction in the VAS score persisted even in the third month. Repetitive ESPBs may be regarded as a straightforward, safe, and replicable intervention to complement medical treatment and diminish the need for opioids in managing lung cancer-related pain.

show abstract

Section: Discussionmentioning

confidence: 99%

Prolonged Effect of Repetitive Erector Spinae Plane Block in Reducing Thoracic Pain Caused by Lung Cancer

Tanyel Saraçoğlu,

Akbaş,

Onay

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…MOR expression is associated with opioid use. Intraoperative opioid use increases MOR expression in cancer tissues ( 36 , 37 ), and also exacerbates shorter survival ( 38 ). Contrarily, sufentanil consumption was higher in the MOR high expression group ( 21 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Mu opioid receptor mRNA overexpression predicts poor prognosis among 18 common solid cancers: A pan-cancer analysis

et al. 2023

View full text Add to dashboard Cite

BackgroundOpioids are widely used for patients with solid tumors during surgery and for cancer pain relief. We conducted a pan-cancer genomic analysis to investigate the prognostic features of Mu opioid receptor (MOR) mRNA expression across 18 primary solid cancers.MethodsAll the data of cancer with MOR mRNA were retrieved from cBioPortal for Cancer Genomics. Logistic regression was used to determine the associations between MOR mRNA expression and clinicopathological features. Log-rank test and Cox regression was used for survival analysis. Subgroup analysis and propensity score matching were also carried out.Results7,274 patients, including 1,112 patients with positive MOR mRNA expression, were included for data analyses. Positive MOR mRNA expression was associated with more advanced stage of T (adjusted Odds ratio [OR], 1.176; 95% confidence interval [CI], 1.022-1.354; P=0.024), M (adjusted OR, 1.548; 95% CI, 1.095-2.189; P=0.013) except N (adjusted OR, 1.145; 95% CI, 0.975-1.346; P=0.101), and worse prognosis for overall survival (Hazard ratio [HR] 1.347, 95% CI 1.200-1.512, P<0.001), progression-free survival (HR 1.359, 95% CI 1.220-1.513, P<0.001), disease-free survival (HR 1.269, 95% CI 1.016-1.585, P<0.001) and disease-specific survival (HR 1.474, 95% CI 1.284-1.693, P<0.001). Patients with positive MOR mRNA expression tended to be classified as tumor microenvironment immune types II, representing low PD-L1 and low CD8A expression.ConclusionMOR mRNA overexpression is associated with poor prognosis and poor response to PD-L1 therapy.

show abstract

“…Studies have shown that even a limited dose of opioids may lead to addiction; long-term opioids use increases the mortality of patients [ 10 , 11 ]. Opioids may lead to tumor growth, angiogenesis and distant spread through transactivation of vascular endothelial growth factor (VEGF) receptors and increased expression of opioid receptors, which is closely related to the prognosis of cancer patients [ 12 ]. High doses of opioids carry a risk of long-term dependence, with 10 percent of patients continuing to use opioids for up to 90 days after undergoing a series of major and minor surgeries [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-guided medial branch of the superior laryngeal nerve block to reduce peri-operative opioids dosage and accelerate patient recovery

Kang,

Wu,

Liu

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

Background To explore whether the medial branch block of superior laryngeal nerve can reduce the stress response of patients undergoing intubation and further reduce the dosage of opioids. Methods 80 patients undergoing gynecological laparoscopic surgery were selected, and randomly divided into 4 groups. All patients in the experimental groups received bilateral internal branch of superior laryngeal nerve block and transversus abdominis plane block. But the dosage of sufentanil used for anesthesia induction in the group A, B, and C was 0.4, 0.2, and 0μg/kg, respectively. Group D do not underwent supralaryngeal nerve block and the dosage of sufentanil was 0.4μg/kg. The heart rate (HR) and mean arterial pressure(MAP) were recorded at the time of entering the operating room(T1), before intubation after induction(T2), immediately after intubation(T3), 5min after intubation(T4), before extubation(T5), immediately after extubation(T6), 5min after extubation(T7). We also recorded the stay time in the recovery room, the number of cases of postoperative sore throat, the number of cases of nausea and vomiting, the first intestinal exhaust time, the length of hospital stay after operation. Results The HR of group A, C and D at T3 was significantly higher than that at T2(P < 0.01), while the HR of group B had no significant change. The HR of group A, C and D at T4 was lower than that at T3(P < 0.01), while the HR of group B had no obvious change. The HR of group C and D at T3 was significantly higher than that at T1 (P < 0.01). The MAP of group A and D at T4 was significantly lower than that at T1 (P<0.001). The first postoperative intestinal exhaust time in group A, B and C was significantly shorter than that in group D. The length of hospital stay after operation in group B and C was shorter than that in group D. Conclusions Ultrasound-guided superior laryngeal nerve block combined with 0.2μg/kg sufentanil can reduce the intubation reaction, have better hemodynamic stability, reduce the first postoperative intestinal exhaust time and postoperative hospital stay, thereby accelerating the postoperative recovery of patients.

show abstract

Effect of Opioids on Survival in Patients with Cancer

Cited by 12 publications

References 61 publications

Prolonged Effect of Repetitive Erector Spinae Plane Block in Reducing Thoracic Pain Caused by Lung Cancer

Prolonged Effect of Repetitive Erector Spinae Plane Block in Reducing Thoracic Pain Caused by Lung Cancer

Mu opioid receptor mRNA overexpression predicts poor prognosis among 18 common solid cancers: A pan-cancer analysis

Ultrasound-guided medial branch of the superior laryngeal nerve block to reduce peri-operative opioids dosage and accelerate patient recovery

Contact Info

Product

Resources

About