Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part II: standard and overcorrection do not cause articular cartilage degeneration

Ziegler, R.; Goebel, Lars; Cucchiarini, Magali; Pape, Dietrich; Madry, Henning

doi:10.1007/s00167-013-2410-6

Cited by 36 publications

(48 citation statements)

References 60 publications

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“…Osteophytes always occurred in the periphery of the anterior and intermediate regions of the medial tibial plateaus, similar to other translational 23 , 31 and clinical studies 32 . Previously, the ovine tibial plateau has been divided into regions based on distinguishing the central and peripheral areas 21 ; meniscus covered and not covered regions 20 ; inner, middle, and outer thirds 22 ; cranial, middle and caudal thirds (each middle third was further divided into axial and abaxial aspects) 23 , 24 as well as grids containing 9 25 or 26 individual subregions 26 . Comparable regions were established on the human tibial plateau, for example by dividing it into meniscus covered and not-covered regions 33 , or in concentric zones (border and centre rings) 34 .…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, 3-D image registration is available to aid with the problem of identical sample orientation 18 , 19 . So far, regions on the ovine tibial plateau were defined either visually (based on the presence of menisci 20 , separation into halves 21 or thirds 22 – 24 ), by mathematical modelling or using measured 25 or projected grids 26 . However, objectively definable and reproducible regions based on stable, easily identifiable reference points are largely lacking.…”

Section: Introductionmentioning

confidence: 99%

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Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces

Oláh

Reinhard

Gao

et al. 2018

Sci Rep

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Selecting identical topographical locations to analyse pathological structural changes of the osteochondral unit in translational models remains difficult. The specific aim of the study was to provide objectively defined reference points on the ovine tibial plateau based on 2-D sections of micro-CT images useful for reproducible sample harvesting and as standardized landmarks for landmark-based 3-D image registration. We propose 5 reference points, 11 reference lines and 12 subregions that are detectable macroscopically and on 2-D micro-CT sections. Their value was confirmed applying landmark-based rigid and affine 3-D registration methods. Intra- and interobserver comparison showed high reliabilities, and constant positions (standard errors < 1%). Spatial patterns of the thicknesses of the articular cartilage and subchondral bone plate were revealed by measurements in 96 individual points of the tibial plateau. As a case study, pathological phenomena 6 months following OA induction in vivo such as osteophytes and areas of OA development were mapped to the individual subregions. These new reference points and subregions are directly identifiable on tibial plateau specimens or macroscopic images, enabling a precise topographical location of pathological structural changes of the osteochondral unit in both 2-D and 3-D subspaces in a region-appropriate fashion relevant for translational investigations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces

Oláh

Reinhard

Gao

et al. 2018

Sci Rep

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“…26 Areas containing OA changes were measured on digitalized photographs (analySIS 5.0; Olympus Soft Imaging System) within a standardized region of interest (width, 3.5-4.0 mm; area, 70 mm 2 ) surrounding the defect. 48 For histological and immunohistochemical evaluations, osteochondral specimens were trimmed and decalcified, and paraffin-embedded transversal sections (4 mm) were stained with safranin orange/fast green (safranin O) and hematoxylin and eosin according to routine protocols. 20 Defect areas were evaluated on a total of 130 histological sections taken from the center of the defects, applying the complex grading system according to Sellers et al 41 (31 points: no repair; 0 points: complete regeneration).…”

Section: Evaluation Of Cartilage Repairmentioning

confidence: 99%

Small Subchondral Drill Holes Improve Marrow Stimulation of Articular Cartilage Defects

et al. 2014

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“…Osteochondral defects provoked significantly more severe osteoarthritic degeneration of the adjacent cartilage than chondral lesions after 6 months in vivo. This time point was chosen based on the extensive experience with ovine cartilage repair after 6 months by several research groups 15,17,19,20,26,[44][45][46] and the suitability of this observation period to assess the development of osteoarthritis. 5 In accordance, Hepp et al 24 confirmed degenerative perilesional changes already 3 months after creation of cylindrical 7 mm osteochondral defects in ovine femoral condyles.…”

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confidence: 99%

Improved repair of chondral and osteochondral defects in the ovine trochlea compared with the medial condyle

Orth

Meyer

Goebel

et al. 2013

Journal Orthopaedic Research

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Associations between topographic location and articular cartilage repair in preclinical animal models are unknown. Based on clinical investigations, we hypothesized that lesions in the ovine femoral condyle repair better than in the trochlea. Full-thickness chondral and osteochondral defects were simultaneously established in the weightbearing area of the medial femoral condyle and the lateral trochlear facet in sheep, with chondral defects subjected to subchondral drilling. After 6 months in vivo, cartilage repair and osteoarthritis development was evaluated by macroscopic, histological, immunohistochemical, and biochemical analyses. Macroscopic and histological articular cartilage repair and type-II collagen immunoreactivity were better in the femoral trochlea, regardless of the defect type. Location-independently, osteochondral defects induced more osteoarthritic degeneration of the adjacent cartilage than drilled chondral lesions. DNA and proteoglycan contents of chondral defects were higher in the condyle, reflecting physiological topographical differences. The results indicate that topographic location dictates the structural patterns and biochemical composition of the repair tissue in sheep. These findings suggest that repair of cartilage defects at different anatomical sites of the ovine stifle joint needs to be assessed independently and that the sheep trochlea exhibits cartilage repair patterns reflective of the human medial femoral condyle. ß

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Effect of open wedge high tibial osteotomy on the lateral tibiofemoral compartment in sheep. Part II: standard and overcorrection do not cause articular cartilage degeneration

Abstract: Opening wedge HTO resulting in both standard and overcorrection is a safe procedure for the articular cartilage in an intact lateral tibiofemoral compartment of adult sheep at 6 months postoperatively.

Cited by 36 publications

References 60 publications

Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces

Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces

Small Subchondral Drill Holes Improve Marrow Stimulation of Articular Cartilage Defects

Improved repair of chondral and osteochondral defects in the ovine trochlea compared with the medial condyle

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