Effect of online tDCS to left somatomotor cortex on neuropsychiatric symptoms among older adults at risk for dementia

Turnbull, Adam; Anthony, Mia; Tadin, Duje; Porsteinsson, Anton P.; Heffner, Kathi L.; Lin, Feng

doi:10.1016/j.cortex.2022.10.015

Cited by 4 publications

(6 citation statements)

References 55 publications

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“…The clinical trial was pre-registered as NCT04099524 at clinicaltrial.gov . Details of the design and intervention can be found in the primary report ( Turnbull et al. , 2023 ).…”

Section: Methodsmentioning

confidence: 99%

“…We recently completed a randomized control trial on the effect of visual attention cognitive training with(out) concurrent transcranial direct current stimulation on left somatomotor cortex (L-SMC) on affective symptoms in older adults with MCI ( Turnbull et al. , 2023 ).…”

Section: Introductionmentioning

confidence: 99%

“…We found tentative evidence for reduced negative affective symptoms via changes in L-SMC activation and L-SMC—amygdala resting-state FC, suggesting improved emotional regulation. In our secondary analyses, we observed two phenomena: (i) there were heterogeneous improvements in EM (episodic memory) and EF (executive function); and (ii) participants across groups displayed varying degrees of positive affect, indicated by more positive valence ratings above ‘neutral’ on the Self-Assessment Manikin (SAM) ( Turnbull et al. , 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults

Anthony,

Turnbull,

Tadin

et al. 2024

Social Cognitive and Affective Neuroscience

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Background Cognitive training for older adults varies in efficacy, but it is unclear why some older adults benefit more than others. Positive affective experience (PAE), referring to high positive valence and/or stable arousal states across everyday scenarios, and associated functional networks, can protect plasticity mechanisms against Alzheimer’s disease neurodegeneration, which may contribute to training outcome variability. Objective Investigate whether PAE explains variability in cognitive training outcomes by disrupting the adverse effect of neurodegeneration on plasticity. Design and Subjects Secondary analysis of a randomized control trial of cognitive training with concurrent real or sham brain stimulation (39 older adults with mild cognitive impairment; mean age, 71). Methods Moderation analyses, with change in episodic memory or executive function as the outcome, PAE or baseline resting-state connectivity as the moderator, and baseline neurodegeneration as the predictor. Results PAE stability and baseline default mode network (DMN) connectivity disrupted the effect of neurodegeneration on plasticity in executive function but not episodic memory. Conclusions PAE stability and degree of DMN integrity both explained cognitive training outcome variability, by reducing the adverse effect of neurodegeneration on cognitive plasticity. We highlight the need to account for PAE, brain aging factors, and their interactions with plasticity in cognitive training.

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“…The clinical trial was pre-registered as NCT04099524 at clinicaltrial.gov . Details of the design and intervention can be found in the primary report ( Turnbull et al. , 2023 ).…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults

Anthony,

Turnbull,

Tadin

et al. 2024

Social Cognitive and Affective Neuroscience

Self Cite

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“…PISTIM electrodes were modeled as a 2 mm thick cylinder with a 2 mm thick conductive gel layer. The electric conductivity values of the electrode and gel were 5.8 × 10 7 S m −1 and 0.3 S m −1 [42], respectively. The sponge electrodes were modeled as a 1 mmthick rubber pad enclosed by a 3 mm-thick sponge.…”

Section: Electric Field Simulationmentioning

confidence: 96%

“…The sponge electrodes were modeled as a 1 mmthick rubber pad enclosed by a 3 mm-thick sponge. The electric conductivity values of the rubber pad and soaked sponge were 29.4 S m −1 [43] and 1.4 S m −1 [42], respectively. The peak electric field strength and focality were computed from the simulation results per subject and stimulation protocol.…”

Section: Electric Field Simulationmentioning

confidence: 99%

Integrating electric field modeling and pre-tDCS behavioral performance to predict the individual tDCS effect on visual crowding

Chen,

Gong

et al. 2023

J. Neural Eng.

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Objective. Transcranial direct current stimulation (tDCS) has been broadly used to modulate brain activity with both bipolar and high-definition montages. However, tDCS effects can be highly variable. In this work, we investigated whether the variability in the tDCS effects could be predicted by integrating individualized electric field modeling and individual pre-tDCS behavioral performance. Approach. Here, we first compared the effects of bipolar tDCS and 4 × 1 high-definition tDCS (HD-tDCS) with respect to the alleviation of visual crowding, which is the inability to identify targets in the presence of nearby flankers and considered to be an essential bottleneck of object recognition and visual awareness. We instructed subjects to perform an orientation discrimination task with both isolated and crowded targets in the periphery and measured their orientation discrimination thresholds before and after receiving 20 min of bipolar tDCS, 4 × 1 HD-tDCS, or sham stimulation over the visual cortex. Individual anatomically realistic head models were constructed to simulate tDCS-induced electric field distributions and quantify tDCS focality. Finally, a multiple linear regression model that used pre-tDCS behavioral performance and tDCS focality as factors was used to predict post-tDCS behavioral performance. Main results. We found that HD-tDCS, but not bipolar tDCS, could significantly alleviate visual crowding. Moreover, the variability in the tDCS effect could be reliably predicted by subjects’ pre-tDCS behavioral performance and tDCS focality. This prediction model also performed well when generalized to other two tDCS protocols with a different electrode size or a different stimulation intensity. Significance. Our study links the variability in the tDCS-induced electric field and the pre-tDCS behavioral performance in a visual crowding task to the variability in post-tDCS performance. It provides a new approach to predicting individual tDCS effects and highlights the importance of understanding the factors that determine tDCS effectiveness while developing more robust protocols.

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Influence of affective states on informant impression of neuropsychiatric symptoms in people living with MCI

Therrien

Turnbull

Anthony

et al. 2023

Aging & Mental Health

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Effect of online tDCS to left somatomotor cortex on neuropsychiatric symptoms among older adults at risk for dementia

Cited by 4 publications

References 55 publications

Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults

Positive affect disrupts neurodegeneration effects on cognitive training plasticity in older adults

Integrating electric field modeling and pre-tDCS behavioral performance to predict the individual tDCS effect on visual crowding

Influence of affective states on informant impression of neuropsychiatric symptoms in people living with MCI

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