Effect of once-daily atenolol on ambulatory blood pressure.

Raftery, Edward B.; Mann, Stewart; Millar-Craig, M W; Balasubramanian, Vijay

doi:10.1136/bmj.1.6158.237-a

Cited by 63 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Direct Intra-Arterial ABPM More than 30 years ago, a series of studies using direct intra-arterial ABPM to provide continuous 24hour BP was conducted by Jim Raftery and his group at Northwick Park Hospital in London and by John Floras and Peter Sleight at the John Radcliffe Hospital in Oxford in which the value of ABPM in assessing the efficacy of BP-lowering drugs was dramatically demonstrated. [6][7][8][9] In the earliest of these studies, atenolol taken once daily in the morning was shown to lower BP during the day but to have little effect on either nighttime BP or the morning rise in BP (Figure 3). The prescient conclusions of this study merit quoting in full because they are as relevant today as when they were written in 1979:…”

Section: The Origins Of Ambulatory Blood Pressure Measurementmentioning

confidence: 99%

“…If treatment aims at lowering BP to a 'normal' level (140 ⁄ 90 mm Hg) clearly it is desirable to lower it to that level throughout the 24-hour cycle. 7 The Oxford Group used intra-arterial ABPM to demonstrate the difference in efficacy and 24-hour duration of action between four b-blocking drugsatenolol, metoprolol, pindolol, and slow-release propranolol-in a double-blind randomized study ( Figure 4). Whereas all 4 b-blockers achieved a significant reduction in mean arterial BP 28 hours after the last single daily dose was taken, the extent to which each drug lowered BP differed during 24 hours and had clinic BP only been measured no difference between these 4 drugs would have emerged.…”

Section: The Origins Of Ambulatory Blood Pressure Measurementmentioning

confidence: 99%

See 1 more Smart Citation

First Thomas Pickering Memorial Lecture*: Ambulatory Blood Pressure Measurement is Essential for the Management of Hypertension

O’Brien

2012

J of Clinical Hypertension

View full text Add to dashboard Cite

Section: The Origins Of Ambulatory Blood Pressure Measurementmentioning

confidence: 99%

Section: The Origins Of Ambulatory Blood Pressure Measurementmentioning

confidence: 99%

First Thomas Pickering Memorial Lecture*: Ambulatory Blood Pressure Measurement is Essential for the Management of Hypertension

O’Brien

2012

J of Clinical Hypertension

View full text Add to dashboard Cite

“…Single measurements in outpatient clinics are unlikely to yield useful information on the effects of drugs on this basic cycle. If treatment aims at lowering blood pressure to a ''normal'' level (140 ⁄ 90 mmHg) clearly it is desirable to lower it to that level throughout the 24-h cycle' [75]. In another early study using intra-arterial ABPM, it was shown that whereas four beta-blockers achieved a significant reduction in mean arterial ABPM, the extent to which each drug did so differed over the 24 h, and importantly the authors highlighted a very basic principle that has too often been forgotten, namely, that had clinic BP only been measured no difference between these four drugs would have emerged [76].…”

Section: Abpm In Pharmacological Researchmentioning

confidence: 99%

Twenty-four-hour ambulatory blood pressure measurement in clinical practice and research: a critical review of a technique in need of implementation

O’Brien

2011

Journal of Internal Medicine

View full text Add to dashboard Cite

Abstract. O'Brien E (The Conway Institute, University College Dublin, Dublin, Ireland). Twenty-four-hour ambulatory blood pressure measurement in clinical practice and research: a critical review of a technique in need of implementation (Review). J Intern Med 2011; 269: 478-495.This review presents evidence that ambulatory blood pressure measurement (ABPM) should be used more widely in clinical practice and hypertension research. The technique, which should be mandatory in trials of antihypertensive drugs, is not being used in all studies of antihypertensive drug efficacy. ABPM is also being under-used in outcome studies. The failure to implement ABPM in primary care and hypertension research is impeding patient management and scientific advancement. ABPM offers so many advantages in assessing the efficacy of blood pressure (BP)-lowering drugs that it should be mandatory in pharmacological trials. Likewise, the technique provides a means of achieving BP control in clinical practice, which is essential if we are to halt the epidemic of the cardiovascular consequences of hypertension. However, if ABPM is to be implemented for these purposes, certain requirements will need to be fulfilled. These include the availability of accurate, patient-friendly and inexpensive devices; standardization of the presentation and plotting of data with summary statistics for day-to-day practice; provision of comprehensive data analysis for research; an interpretative report to facilitate use in busy clinical practice; a trend report to demonstrate efficacy or otherwise of treatment in clinical practice and online transmission of data to provide immediate real-time data analysis. The reasons why ABPM is not being implemented are reviewed, and proposals are made to make the technique more acceptable.

show abstract

“…79,80 Since then, hallmark studies have shown important corollary results with the use of 24-hour ABPM. 79,80 One such study, the HOPE (Heart Outcomes Prevention Evaluation) trial, 81 demonstrated the potential importance of 24-hour blood pressure control in regards to cardiovascular events. This study demonstrated that the angiotensin-converting enzyme inhibitor, ramipril, significantly reduced cardiovascular morbidity and mortality in patients at high risk for cardiovascular events.…”

mentioning

confidence: 99%

Circadian variations in blood pressure in health and disease: implications for patient management

Chugh¹,

Loughran²,

Slaughter³

2011

CPT

View full text Add to dashboard Cite

Abstract:Traditionally, blood pressure measurements have been performed in office settings and have provided the basis for all diagnostic and therapeutic decisions. However, the development of a clinically relevant 24-hour blood pressure monitoring system has added greatly to the ability of blood pressure values to confer additional clinical information, including prognostic value. Mechanistically, the circadian rhythm of blood pressure is mediated by a complex process as a part of the neurohormonal cascade. Pattern recognition of blood pressure peaks and troughs over a 24-hour period has led to categorization into specific subsets namely, ie, dippers, nondippers, extreme dippers, and reverse dippers. Cardiovascular risk is associated with certain pattern types, as has been demonstrated in large observational and prospective studies. The development of therapies for the purpose of restoring more pathological patterns to normal ones continues to grow. These include both pharmaceutical and device therapy. This article describes the development of 24-hour blood pressure monitoring systems, the identification of circadian blood pressure patterns, and the treatment strategies studied thus far which affect these newer blood pressure parameters.

show abstract

Effect of once-daily atenolol on ambulatory blood pressure.

Cited by 63 publications

References 2 publications

First Thomas Pickering Memorial Lecture*: Ambulatory Blood Pressure Measurement is Essential for the Management of Hypertension

First Thomas Pickering Memorial Lecture*: Ambulatory Blood Pressure Measurement is Essential for the Management of Hypertension

Twenty-four-hour ambulatory blood pressure measurement in clinical practice and research: a critical review of a technique in need of implementation

Circadian variations in blood pressure in health and disease: implications for patient management

Contact Info

Product

Resources

About