Effect of omnivorous and vegan diets with different protein and carbohydrate content on growth and metabolism of growing rats

Giuberti, Gianluca; Morlacchini, M.; Crippa, Luca; Capraro, Jessica; Paganini, Beatrice; Gallo, Antonio; Rossi, Filippo

doi:10.1080/09637486.2017.1394986

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Deficient Diet: Methionine, Creatine, or Calorie Lack A plant-based diet is almost universally regarded as better for cardiovascular health, albeit with potential growth retardation in young animals [17][18]. Plant-based diets are creatine-free, and within the context of a high creatine demand (because of high CK) [13], SHR had to synthesize creatine de novo from arginine and lysine, needing methionine, an essential amino acid involved in cysteine and glutathione synthesis, and the primary methyl donor in creatine synthesis [1,19].…”

Section: Hypothesesmentioning

confidence: 99%

Paradoxical Increase in Body Mass Induced by Beta-Guanidinopropionic Acid in Juvenile Spontaneously Hypertensive Rats

Brewster¹

2021

Cureus

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Background The adenosine triphosphate (ATP) regenerating enzyme creatine kinase (CK) is intimately involved in blood pressure generation. Consequently, the creatine transporter and CK inhibitor beta-guanidinopropionic acid (GPA) successfully reduced blood pressure in 16-week-old spontaneously hypertensive rats (SHR), but GPA may cause growth retardation in juvenile mammals. This report considers a serendipity observation of paradoxical growth increase after using GPA to prevent hypertension in three-week-old SHR. Methods Implementing the “Animal Research: Reporting of In Vivo Experiments” (ARRIVE) guideline, male, three-week-old spontaneously hypertensive rats (N=22) were randomly assigned to standard soy-based (creatine-free) chow with GPA 0.1% vs control chow during four weeks (primary, t=4w) or six weeks of treatment (t=6w). Blood pressure measured by the tail-cuff method was the main outcome. Other outcomes included body mass and contractility characteristics of isolated arteries. Results Body mass at baseline was 28.4 (SE 0.71) g (n=22). With similar food intake/100 gram animal in both groups, GPA-treated rats (n=11) developed a strikingly larger body size and mass: t=4w, GPA 110.4 g (3.7) vs controls (n=11) 65.0 g (4.8) (+69.8%; p<0.001); t=6w, GPA 154.3 (4.7) vs controls 68.0 (4.7) g. There were no significant differences in cardiovascular parameters including blood pressure. Discussion An unexpected increase in body mass and size without concurrent blood pressure increase was observed in juvenile SHR on GPA vs control soy-based chow. It is speculated that the partial creatine agonist activity of GPA contributed to these effects. Further studies are needed to confirm these findings and better understand the impact of modulating energy metabolism in juvenile hypertension-prone mammals.

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Section: Hypothesesmentioning

confidence: 99%

Paradoxical Increase in Body Mass Induced by Beta-Guanidinopropionic Acid in Juvenile Spontaneously Hypertensive Rats

Brewster¹

2021

Cureus

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Animal Protein Intake Is Associated with Obesity Remission After Roux-en-Y Gastric Bypass: an Isocaloric Replacement Analysis

et al. 2023

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A Comprehensive Investigation into the Relationship between Dietary Therapy Strategies for Metabolic Illnesses and the Underlying Myriad Factors

Kusmy,

Saxena Pal,

Chaitanya

et al. 2024

CNF

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Maintaining a well-balanced diet and considering how to fulfill all the adequate nutrition required by the body will help us live a healthy lifestyle. The risk of illness, infection, exhaustion, and poor performance increases when a balanced diet is absent. The anti-treatment technique of food modification has gained a lot of attention in research over the past few decades. Popular diets include Mediterranean, vegan, and low-carbohydrate diets. The vegan diet is a plant-based eating plan that eliminates animal products and emphasizes fruits, vegetables, legumes, whole grains, nuts, and seeds. The Palaeolithic age diet emphasizes eating full, unprocessed foods available to early people while avoiding grains, legumes, dairy products, refined sugar, and processed foods. Proponents claim it can improve health, and aid in weight loss. Numerous dietary patterns, such as caloric restriction (CR), dietary approaches to stop hypertension (DASH), ketogenic diets (KD), the Mediterranean diet (Medi), and Mediterranean-DASH diet Intervention for Neurological Delay (MIND) diet, have been tried to reduce body weight, any other disease infections, and cognitive decline. Increased Mediterranean diet adherence was linked to reductions in cardiovascular and neurological conditions, including Alzheimer's disease (AD) and related cognitive loss. The MIND diet, a new good dietary pattern has been linked to a significantly lower incidence of AD and slower rates of cognitive deterioration. The current piece of work emphasizes the introduction, nutritional components, and health advantages of different types of diet.

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Effect of omnivorous and vegan diets with different protein and carbohydrate content on growth and metabolism of growing rats

Cited by 3 publications

References 38 publications

Paradoxical Increase in Body Mass Induced by Beta-Guanidinopropionic Acid in Juvenile Spontaneously Hypertensive Rats

Paradoxical Increase in Body Mass Induced by Beta-Guanidinopropionic Acid in Juvenile Spontaneously Hypertensive Rats

Animal Protein Intake Is Associated with Obesity Remission After Roux-en-Y Gastric Bypass: an Isocaloric Replacement Analysis

A Comprehensive Investigation into the Relationship between Dietary Therapy Strategies for Metabolic Illnesses and the Underlying Myriad Factors

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