Effect of omeprazole and clarithromycin plus tinidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer

Bazzoli, Franco; Gullini, S.; Zagari, R.M.; Pazzi, P.; Libera, Mauro Dalla; Pozzato, P.; Sottill, S.; Fossi, S.; Carli, Giuliano; Scagliarini, R.; Simoni, Patrizia; Roda, Enrico

doi:10.1016/0016-5085(95)22892-6

Cited by 18 publications

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“…Eradication of H. pylori is the therapeutic end‐point of the research being done on this organism with the aim of finding a drug regimen which would achieve cure rates approximating 100% without compromising on drug compliance and tolerability 9 . Bazzoli’s regimen consisting of omeprazole, clarithromycin and tinidazole achieved a cure rate of 94.6% for H. pylori and has become a useful benchmark to compare other eradication therapies 10 . In our study, we used triple drug therapies in accordance with the Bazzoli regimen.…”

Section: Discussionmentioning

confidence: 99%

Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country

Ahuja

Dhar

Bal

et al. 1998

Aliment Pharmacol Ther

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Section: Discussionmentioning

confidence: 99%

Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country

Ahuja

Dhar

Bal

et al. 1998

Aliment Pharmacol Ther

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“…This finding is consistent with those of other investigators, who found that the number of patients in whom H. pylori was eradicated was lower than the number in whom duodenal ulcer had healed 2 , . 7 , 13 , 14 The healing of ulcers in patients in whom H. pylori is not eradicated could be a result of very marked acid suppression achieved by the proton pump inhibitors, which were given at double the usual duodenal ulcer healing dose. Healing could also be due to suppression of H. pylori during, or after, the treatment.…”

Section: Discussionmentioning

confidence: 99%

Incidence of duodenal ulcer healing after 1 week of proton pump inhibitor triple therapy for eradication of Helicobacter pylori

Harris

Misiewicz

Bardhan³

et al. 1998

Aliment Pharmacol Ther

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“…In a meta‐analysis by Chiba et al which was irrespective of dose and duration of treatment, the combination of omeprazole, clarithromycin and metronidazole was superior to omeprazole, amoxycillin and metronidazole (90 vs 84.1% on a sample of 842 and 931 patients, respectively) 42 . In seven studies 4 , 29 , 35 –37 , 39 on a sample of 273 patients treated with low‐dose clarithromycin (250 mg b.i.d.) for 1 week in association with omeprazole and nitroimidazole, an average eradication rate of 93% was achieved, ranging from 90–96% 40 .…”

Section: Discussionmentioning

confidence: 99%

Low dose of clarithromycin in triple therapy for the eradication of Helicobacter pylori: One or two weeks?

Bò

Mario

Battaglia

et al. 1998

J of Gastro and Hepatol

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The aims of this pilot study were: (i) to compare the efficacy of low-dose clarithromycin (250 mg twice daily) for 1 or 2 weeks; and (ii) to evaluate possible therapeutic advantages in associating the low-dose clarithromycin with an anti-secretory agent or tripotassium dicitrate bismuthate (De Nol; Yamanouchi Pharm, Corugate Milano, Italy). A prospective, randomized, open trial was carried out on consecutive outpatients with dyspeptic symptoms and Helicobacter pylori infection. We enrolled 129 patients in one of the following schedules: (A) De Nol 120 mg q.i.d., clarithromycin 250 mg b.i.d. and metronidazole 250 mg q.i.d. for 2 weeks; (B) omeprazole 20 mg b.i.d., clarithromycin 250 mg b.i.d. and metronidazole 250 mg q.i.d. for 2 weeks; or (C) omeprazole 20 mg b.i.d., clarithromycin 250 mg b.i.d. and metronidazole 250 mg q.i.d. for 1 week. Results were evaluated by Per Protocol (PP) and Intention-To-Treat analysis (ITT). Eradication rate was 100% after treatment A, 92.6% after treatment B and 86.5% after treatment C by PP and 83.3, 75.7, and 68.1%, respectively by ITT. Side effects were reported by 16 subjects: 26.6% in group A; 9.1% in group B; and 7.5% in group C; in two cases side effects led to the withdrawal of the treatment. In conclusion, 500 mg clarithromycin per day in association with omeprazole and metronidazole, for 1 week gave comparable results to the same schedule for a 2 week period. The use of clarithromycin with bismuth and metronidazole produced a therapeutic gain compared with both of the anti-secretory schedules, although this was not statistically significant.

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Effect of omeprazole and clarithromycin plus tinidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer

Cited by 18 publications

References 0 publications

Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country

Lansoprazole and secnidazole with clarithromycin, amoxycillin or pefloxacin in the eradication of Helicobacter pylori in a developing country

Incidence of duodenal ulcer healing after 1 week of proton pump inhibitor triple therapy for eradication of Helicobacter pylori

Low dose of clarithromycin in triple therapy for the eradication of Helicobacter pylori: One or two weeks?

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