Effect of omega‐3 fatty acids supplementation on indirect blood markers of exercise‐induced muscle damage: Systematic review and meta‐analysis of randomized controlled trials

Gào, Xīn; Eshaghi, Hesam

doi:10.1002/fsn3.2598

Cited by 11 publications

(8 citation statements)

References 69 publications

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“…Although mean values for serum CK concentrations were markedly lower in FO than PLA on days 2 (−586 μg/L) and 3 (−719 μg/L) post exercise (Figure 2), these differences did not reach statistical significance when expressed over time or as cumulative AUC. This observation contrasts with a recent meta-analysis conducted in untrained males that revealed FO supplementation attenuated the rise in various blood biomarkers of muscle damage, including CK, myoglobin, and LDH (Xin & Eshaghi, 2021). Taken together, these findings indicate the protective action of Ω3-PUFA in ameliorating EIMD may be specific to untrained individuals who experience a greater severity of myofibrillar disruption given the unaccustomed nature of exercise.…”

Section: Discussioncontrasting

confidence: 90%

Fish oil supplementation fails to modulate indices of muscle damage and muscle repair during acute recovery from eccentric exercise in trained young males

Mackay

Bowles

Macgregor

et al. 2023

European Journal of Sport Science

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We aimed to investigate the influence of 4-wk of fish oil (FO) supplementation on markers of muscle damage, inflammation, muscle soreness, and muscle function during acute recovery from eccentric exercise in moderately trained males. Sixteen moderately-trained males ingested 5 g/d of FO (n = 8) or soybean oil (placebo) capsules (n = 8) for 4-wk prior to-and 3-d following an acute eccentric exercise bout. Eccentric exercise consisted of 12 sets of isokinetic knee extension and knee flexion. Indices of muscle damage, soreness, function and inflammation were measured at baseline and during exercise recovery. Eccentric exercise elicited an increase in muscle soreness (p < 0.010) and thigh volume (p < 0.001), and reduced peak isometric torque by 31.7 ± 6.9%, (p < 0.05, 95% CI 10.6-52.8) during 3-d of recovery. Blood omega-3 polyunsaturated fatty acid concentration was 14.9 ± 2.4% higher in FO than PLA (p < 0.01, 95% CI 9.8-20.1). However, FO did not ameliorate the cumulative creatine kinase response (expressed as AUC; p = 0.368), inflammation (p = 0.400), muscle soreness (p > 0.140), or muscle function (p > 0.249) following eccentric exercise. FO supplementation confers no clear benefit in terms of ameliorating the degree of muscle damage, or facilitating the muscle repair process, during acute eccentric exercise recovery. These data suggest that FO supplementation does not provide an effective nutritional strategy to promote exercise recovery, at least in moderatelytrained young men.

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Section: Discussioncontrasting

confidence: 90%

Fish oil supplementation fails to modulate indices of muscle damage and muscle repair during acute recovery from eccentric exercise in trained young males

Mackay

Bowles

Macgregor

et al. 2023

European Journal of Sport Science

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“…However, according to [51,52], only some of the ASD patients with mitochondrial dysfunction had elevated CK levels. The significantly lower CK reported in rats fed fish (Figure 3A) could find support in the previous study of [53] who showed that ω-3 was effective in lowering CK and LDH serum levels in healthy persons. Therefore, ω-3 should be prioritised as a recovery agent for exercise-induced muscle damage in therapies.…”

Section: Discussionsupporting

confidence: 82%

Ameliorative Effect of Omega-3-Rich Fish Diet on the Neurotoxic Effects of Propionic Acid in a Rodent Model of Autism

Alsaqer,

Al-Nouri,

Bhat

et al. 2023

Applied Sciences

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Despite the increased social and financial burden associated with autism spectrum disorder (ASD), no particular treatment for this illness has been identified. A detailed examination of prior trials conducted to treat autism revealed that nutrition intervention was commonly utilised as an additional method of therapy. Indeed, the early detection of nutritional deficiencies and metabolic problems, together with appropriate therapeutic measures, can be a cornerstone for enhancing the metabolic and behavioural abilities of individuals with autism. In this work, a propionic acid (PPA)-induced rodent model of ASD was fed Spangled emperor (Lethrinus nebuloses), Dusky grouper (Epinephelus marginatus), and Parrot Fish (Scaridae), which are locally named Hammour, Shour, and Hareed, respectively, in Saudi Arabia. The aim of this study was to investigate the effect of dietary intervention with three kinds of whole fish (Lethrinus nebuloses, Epinephelus marginatus, and Scaridae), as a rich source of ω-3 fatty acids, on selected biochemical markers (reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS), creatine kinase (CK), lactate dehydrogenase (LDH), dopamine) together with a histopathological examination of the cerebellum and hippocampus as neurotoxic features of propionic acid in a rodent model of autism. Briefly, our findings give preliminary evidence in favour of employing fish as a rich supply of omega-3 fatty acids to reduce the neurotoxic effect of a PPA-induced ASD in a rat model. It may be beneficial to provide an extra marine omega-3-rich diet for improving certain metabolic autistic features related to oxidative stress, energy metabolism, and brain neurotransmitters.

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“…For instance, Kyriakidou et al [ 102 ] showed that 4 weeks of n-3 PUFA supplementation successfully attenuated minor aspects of EIMD, although it did not improve performance. Recent systematic reviews and meta-analyses have corroborated the efficacy of n-3 PUFAs in reducing DOMS and markers of muscle damage [ 103 , 104 ]; however, only a few studies have found significantly lower maximal muscle strength loss or recovery (i.e., maximal voluntary contraction; MVC), indicated as the best indirect marker of muscle damage, probably because of a poor control of the participants’ diet characteristics affecting the n-6/n-3 ratio and the use of a broad range of supplementation doses and times. Therefore, more studies assessing MVC after damage are warranted.…”

Section: Clinical Interventions Supporting the Consumption Of N-3 Puf...mentioning

confidence: 99%

The Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review

et al. 2023

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Skeletal muscle is the largest tissue in the human body, comprising approximately 40% of body mass. After damage or injury, a healthy skeletal muscle is often fully regenerated; however, with aging and chronic diseases, the regeneration process is usually incomplete, resulting in the formation of fibrotic tissue, infiltration of intermuscular adipose tissue, and loss of muscle mass and strength, leading to a reduction in functional performance and quality of life. Accumulating evidence has shown that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and their lipid mediators (i.e., oxylipins and endocannabinoids) have the potential to enhance muscle regeneration by positively modulating the local and systemic inflammatory response to muscle injury. This review explores the process of muscle regeneration and how it is affected by acute and chronic inflammatory conditions, focusing on the potential role of n-3 PUFAs and their derivatives as positive modulators of skeletal muscle healing and regeneration.

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Effect of omega‐3 fatty acids supplementation on indirect blood markers of exercise‐induced muscle damage: Systematic review and meta‐analysis of randomized controlled trials

Cited by 11 publications

References 69 publications

Fish oil supplementation fails to modulate indices of muscle damage and muscle repair during acute recovery from eccentric exercise in trained young males

Fish oil supplementation fails to modulate indices of muscle damage and muscle repair during acute recovery from eccentric exercise in trained young males

Ameliorative Effect of Omega-3-Rich Fish Diet on the Neurotoxic Effects of Propionic Acid in a Rodent Model of Autism

The Role of Omega-3 Polyunsaturated Fatty Acids and Their Lipid Mediators on Skeletal Muscle Regeneration: A Narrative Review

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