Effect of omega‐3 fatty acids on canine atopic dermatitis

Mueller, Ralf S.; Fieseler, Kathryn V.; Fettman, Martin J.; Zabel, Sonja; Rosychuk, Rod A.W.; Ogilvie, Gregory K.; Greenwalt, T. L.

doi:10.1111/j.1748-5827.2004.tb00238.x

Cited by 73 publications

(95 citation statements)

References 25 publications

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“…Among the animals of atopic dermatitis, the mouse, guinea pig (Fukuda et al, 2003), cat (Schleifer and Willemse, 2003), dog (Mueller et al, 2004) and horse (Lorch et al, 2001) are used. Mouse model of atopic dermatitis gets wider acceptance.…”

Section: Discussionmentioning

confidence: 99%

Mouse model of DNCB-induced atopic dermatitis

Hamad

Han

Rather

2017

Bangladesh J Pharmacol

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Atopic dermatitis is a skin disease characterized by allergic skin inflammation, redness and itching. The animal model is necessary to find out new drugs. The DNCB-induced animal model of atopic dermatitis includes the following steps: 1) Selection of animals; 2) Shaving of dorsal skin; 3) Applying DNCB once in 24 hours for three days; 4) Monitoring the development of atopy on day 4 post DNCB application. Further, the efficacy of reference drug can be determined by applying on the atopy skin, depends on the nature and aim of the work.

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Section: Discussionmentioning

confidence: 99%

Mouse model of DNCB-induced atopic dermatitis

Hamad

Han

Rather

2017

Bangladesh J Pharmacol

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“…Different species including mice, dogs, cats and horses have been reported to develop AE-like skin lesions [13, 14, 15]. AE-like symptoms in dogs, cats or horses are diseases present in these domestic companions and are treated as disease states by veterinarians.…”

Section: Mouse Models Of Aementioning

confidence: 99%

Mouse Models of Atopic Eczema Critically Evaluated

Gutermuth¹,

Ollert

Ring³

et al. 2004

Int Arch Allergy Immunol

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Atopic eczema (AE) is a chronic relapsing inflammatory skin disorder with increasing prevalence in Western societies. Even though we have made considerable progress in understanding the cellular and molecular nature of cutaneous inflammation, the precise pathomechanisms of AE still remain elusive. Experimental animal models are indispensable tools to study the pathogenic mechanisms and to test novel therapeutic approaches in vivo. For AE a considerable number of mouse models have been proposed and have been used to study specific aspects of the disease, such as genetics, skin barrier defects, immune deviations, bacteria–host interactions or the role of cytokines or chemokines in the inflammatory process. While some models closely resemble human AE, others appear to reflect only specific aspects of the disease. Here we review the currently available mouse models of AE in light of the novel World Allergy Organization classification of eczematous skin diseases and evaluate them according to their clinical, histopathological and immunological findings. The pathogenetic analogies between mice and men will be discussed.

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“…Supplementation of DHA has been shown in various studies carried out in various organisms to yield in increased concentrations of DHA as well as EPA in serum lipids (17,18,31) . Our data support this aspect of previous reports in a mouse model investigating the fatty acid composition of serum TAG, phospholipids and cholesteryl esters.…”

Section: Discussionmentioning

confidence: 99%

Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution

et al. 2008

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Dietary fatty acids have been shown to influence allergic sensitisation. Both n-3 and n-6 PUFA are involved in targeted mediation of inflammatory responses during allergic sensitisation and manifestation of atopic diseases. In the present experiments we investigated whether supplementation of DHA-enriched fish oil partly substituting dietary sunflower-seed oil, in comparison with sunflower-seed oil, supplemented to mice influences fatty acid composition of serum lipid classes. The effects of the two different diets were also investigated depending on allergic sensitisation. Supplementation of DHA and EPA in doses of 2 and 0·12 % (w/w) to non-sensitised and sensitised mice resulted in significantly increased percentile contributions of DHA to all lipid classes. In contrast, serum values of the n-6 PUFA arachidonic acid (AA) were significantly lower, both in nonsensitised and sensitised mice fed the DHA-enriched diet. The fatty acid composition of serum lipids also reflected allergic sensitisation: the EPA:AA ratio in TAG, cholesteryl esters and phospholipids in non-supplemented animals fell to 23, 29 and 29 % respectively of the original value after allergic sensitisation, whereas it decreased to 70, 80 and 76 % respectively only in the animals supplemented with DHA. In summary, allergic sensitisation alone decreased significantly the EPA:AA ratios in serum TAG, while concomitant supplementation of DHA-enriched fish oil ameliorated this decrease. We postulate from the present results that the amelioration of the severity of allergic sensitisation after DHA supplementation may be linked to altered ratios of the eicosanoid precursors EPA and AA as well as DHA needed for further metabolic activation to pro-or anti-inflammatory bioactive lipids.

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Effect of omega‐3 fatty acids on canine atopic dermatitis

Cited by 73 publications

References 25 publications

Mouse model of DNCB-induced atopic dermatitis

Mouse model of DNCB-induced atopic dermatitis

Mouse Models of Atopic Eczema Critically Evaluated

Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution

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