Effect of omega-3 fatty acid supplementation on telomere length and telomerase activity: A systematic review of clinical trials

Silva, Alessandra da; Silveira, Brenda Kelly Souza; Hermsdorff, Helen Hermana Miranda; Silva, Walmir da; Bressan, Josefina

doi:10.1016/j.plefa.2022.102451

Cited by 6 publications

(5 citation statements)

References 54 publications

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“…Senescence of senescent cells or telomere attrition is an important cause of senescence, and therefore, anti-aging strategies by scavenging senescent cells and reducing the attrition of telomeres are also potential pharmacological strategies. 30,31 Current research suggests that aging is primarily associated with nutrient sensing disorders, mitochondrial dysfunction, and cellular senescence, 23 but there are many questions about how to reverse or delay aging, which needs to be further explored.…”

Section: Aging and Anti-aging Therapymentioning

confidence: 99%

Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging

Luo

Huang

et al. 2023

Food Funct.

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Section: Aging and Anti-aging Therapymentioning

confidence: 99%

Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging

Luo

Huang

et al. 2023

Food Funct.

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“…In addition, there are many studies demonstrating that telomere length increases as the n-6:n-3 ratio decreases [8,10,14]. Supplementation of dietary Omega-3 fatty acid may also be beneficial in reducing aging [42][43][44]. Furthermore, a recent MR study, which investigated the association between different fatty acids types and FI, found that, while there wasn't a strong correlation observed with MUFAs or PUFAs, plasma stearic acid levels, which is one of the saturated fatty acids, showed a statistically significant association with a higher FI (β = 0.178; 95% CI = 0.050-0.307; p = 0.007) [45].…”

Section: Discussionmentioning

confidence: 99%

Relationship between fatty acid intake and aging: a Mendelian randomization study

Chen,

Yang,

Wang

et al. 2024

Aging

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Background: Observational studies have previously shown a possible link between fatty acids and aging-related diseases, raising questions about its health implications. However, the causal relationship between the two remains uncertain. Methods: Univariable and multivariable Mendelian randomization (MR) was used to analyze the relationship between five types of fatty acids—polyunsaturated fatty acid (PUFA), monounsaturated fatty acid (MUFA), saturated fatty acid (SFA), Omega-6 fatty acid (Omega-6 FA), and Omega-3 fatty acid (Omega-3 FA) and three markers of aging: telomere length (TL), frailty index (FI), and facial aging (FclAg). The primary approach for Mendelian randomization (MR) analysis involved utilizing the inverse variance weighted (IVW) method, with additional supplementary methods employed. Results: Univariate MR analysis revealed that MUFA, PUFA, SFA, and Omega-6 fatty acids were positively associated with TL (MUFA OR: 1.019, 95% CI: 1.006-1.033; PUFA OR: 1.014, 95% CI: 1.002-1.026; SFA OR: 1.016, 95% CI: 1.002-1.031; Omega-6 FAs OR=1.031, 95% CI: 1.006-1.058). PUFA was also associated with a higher FI (OR: 1.033, 95% CI: 1.009-1.057). In multivariate MR analysis, after adjusting for mutual influences among the five fatty acids, MUFA and PUFA were positively independently associated with TL (MUFA OR: 1.1508, 95% CI = 1.0724-1.2350; PUFA OR: 1.1670, 95% CI = 1.0497-1.2973, while SFA was negatively correlated (OR: 0.8005, 95% CI: 0.7045-0.9096). Conclusions: Our research presents compelling evidence of a causal association between certain fatty acids and indicators of the aging process. In particular, MUFA and PUFA may play a role in slowing down the aging process, while SFAs may contribute to accelerated aging. These findings could have significant implications for dietary recommendations aimed at promoting healthy aging.

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“…Presumably, it has been hypothesised that the intake of omega-3 PUFA from fish consumption might promote the maintenance of TL through its anti-inflammatory properties. Although the relationship between fish consumption and TL remains unclear, there seems to be evidence that supports the protective action of marine omega-3 PUFA against telomere attrition [ 14 , 51 , 52 , 53 , 54 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…Aside from the foods or food groups, other dietary intake factors that were positively associated with TL in the young population found in this review were PUFA and TAC [ 67 ]. According to available evidence, the positive effect of PUFA on TL was mainly due to the intake of omega-3 PUFA [ 14 , 51 , 52 , 53 , 54 , 55 ]. Although PUFA may play a role in regulating gene expression implicated in metabolic alterations and chronic diseases [ 68 ], the association between omega-3 PUFA and TL cannot be firmly stated, let alone the influence of omega-6 PUFA or the role of overall PUFA intake concerning TL.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Foods, Nutrients, or Dietary Patterns on Telomere Length in Childhood and Adolescence: A Systematic Review

et al. 2022

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Environmental factors such as diet can affect telomere length (TL) dynamics. However, the role that children’s and adolescents’ diets play in maintaining TL is not well understood. Thus, we conducted a systematic review to examine the association between the intake of nutrients, foods, food groups, and/or dietary patterns and TL in childhood and adolescence. Following the PRISMA guidelines, we searched MEDLINE via PubMed, Embase, and Cochrane databases and additional registers and methods. The five selected studies were cross-sectional and conducted in children and adolescents aged 2 to 18 years. The main results suggest that a higher consumption of fish, nuts and seeds, fruits and vegetables, green leafy and cruciferous vegetables, olives, legumes, polyunsaturated fatty acids, and an antioxidant-rich diet might positively affect TL. On the contrary, a higher intake of dairy products, simple sugar, sugar-sweetened beverages, cereals, especially white bread, and a diet high in glycaemic load were factors associated with TL shortening. To our knowledge, this is the first systematic review examining the impact of dietary intake factors on TL in childhood and adolescence. Although limited, these results are consistent with previous studies in different adult populations. Further research is needed to ascertain potential nutritional determinants of TL in childhood and adolescence.

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Effect of omega-3 fatty acid supplementation on telomere length and telomerase activity: A systematic review of clinical trials

Cited by 6 publications

References 54 publications

Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging

Targeting AMPK signaling by polyphenols: a novel strategy for tackling aging

Relationship between fatty acid intake and aging: a Mendelian randomization study

The Impact of Foods, Nutrients, or Dietary Patterns on Telomere Length in Childhood and Adolescence: A Systematic Review

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