Effect of Omega-3 and Vitamins E + C Supplements on the Concentration of Serum B-Vitamins and Plasma Redox Aminothiol Antioxidant Status in Elderly Men after Strength Training for Three Months

Stea, Tonje Holte; Stølevik, Solvor B.; Berntsen, Sveinung; Bastani, Nasser E.; Paulsen, Gøran; Seiler, Hilde Lohne; Hetlelid, Ken J.; Blomhoff, Rune; Mansoor, Mohammad Azam

doi:10.1159/000443847

Cited by 5 publications

(6 citation statements)

References 56 publications

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“…While the available information is limited and currently inconclusive, a randomized controlled trial in young healthy subjects showed that daily intake of fish oil (2 g; majorly consisting of DHA and EPA) resulted in a significant decrease of SUA after 4 and 8 weeks of supplementation [27]. A similar significant decline in SUA was also observed in healthy elderly men consuming daily supplement pills characterized by ω-3 FAs such as DHA and EPA for three months, although the change was not extensive [28]. Based on these pieces of evidence, increasing the daily intake of ω-3 FAs via eating pattern changes, such as appropriate choice of aliments and cooking oils, might be beneficial to health in terms of SUA management.…”

Section: Discussionmentioning

confidence: 95%

Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber

et al. 2020

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The beneficial effects of fatty acids (FAs) on human health have attracted widespread interest. However, little is known about the impact of FAs on the handling of urate, the end-product of human purine metabolism, in the body. Increased serum urate levels occur in hyperuricemia, a disease that can lead to gout. In humans, urate filtered by the glomerulus of the kidney is majorly re-absorbed from primary urine into the blood via the urate transporter 1 (URAT1)-mediated pathway. URAT1 inhibition, thus, contributes to decreasing serum urate concentration by increasing net renal urate excretion. Here, we investigated the URAT1-inhibitory effects of 25 FAs that are commonly contained in foods or produced in the body. For this purpose, we conducted an in vitro transport assay using cells transiently expressing URAT1. Our results showed that unsaturated FAs, especially long-chain unsaturated FAs, inhibited URAT1 more strongly than saturated FAs. Among the tested unsaturated FAs, eicosapentaenoic acid, α-linolenic acid, and docosahexaenoic acid exhibited substantial URAT1-inhibitory activities, with half maximal inhibitory concentration values of 6.0, 14.2, and 15.2 μM, respectively. Although further studies are required to investigate whether the ω-3 polyunsaturated FAs can be employed as uricosuric agents, our findings further confirm FAs as nutritionally important substances influencing human health.

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Section: Discussionmentioning

confidence: 95%

Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber

et al. 2020

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“…Similarly, PUFA intake was lower in the high uric acid group. Previous studies examining the relationship between fatty acid intake and serum uric acid levels include a randomized controlled trial comparing the effects of fish oil intake containing n-3 PUFA [14], an intervention study using n-3 PUFA supplements [15], and an intervention study using a calorie-restricted diet in which SFA was replaced with unsaturated fatty acids [16]. The difference in the fatty acid intake between the two uric acid level groups observed in this study seems to be consistent with these previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding dietary style, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean diet reduce serum uric acid [11][12][13]. However, only a few studies have investigated the relationship between serum uric acid levels and dietary lipids [14][15][16]. An intervention study in healthy young adults revealed that n-3 polyunsaturated fatty acid intake with 2 g/day of fish oil for 8 weeks reduced serum uric acid levels [14].…”

Section: Introductionmentioning

confidence: 99%

“…An intervention study in healthy young adults revealed that n-3 polyunsaturated fatty acid intake with 2 g/day of fish oil for 8 weeks reduced serum uric acid levels [14]. Another intervention study in healthy older males reported that a 3-month intake of 700 mg/day of omega-3 lipid supplements reduced serum uric acid levels [15]. Regarding dietary style, a 16-week intervention with a calorie-restricted diet in which saturated fatty acids were substituted for monounsaturated and polyunsaturated fatty acids was shown to induce weight loss and reduce serum uric acid levels in males with gout [16].…”

Section: Introductionmentioning

confidence: 99%

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Association between Dietary Fat Intake and Hyperuricemia in Men with Chronic Kidney Disease

et al. 2022

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Despite a close relationship between chronic kidney disease (CKD) and uric acid level, few studies have examined the relationship between uric acid level and fat intake by kidney function status. Therefore, we investigated the association between dietary fat intake and hyperuricemia with and without decreased kidney function in males living in Shika Town, Ishikawa Prefecture, Japan. This study included 361 males with a mean age of 60.7 years. Dietary fat and fatty acid intakes were evaluated using the brief-type self-administered diet history questionnaire. Reduced kidney function was defined as an estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2, while hyperuricemia was defined as a serum uric acid level > 7.0 mg/dL. A two-way analysis of covariance showed that saturated fatty acid (p = 0.026), monounsaturated fatty acid (p = 0.014), and polyunsaturated fatty acid (p = 0.022) were significantly lower in the high uric acid group than in the normal uric acid group. In multiple logistic analysis stratified by renal function, lipid intake was negatively associated with hyperuricemia in the low eGFR group. These findings suggest that higher dietary lipid/fatty acid intake may be effective in the prevention and treatment of hyperuricemia in men with CKD.

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“…An in vitro study using URAT1-expressing 293A cells reported that EPA and DHA were strong inhibitors of URAT1 dependent urate transport leading the authors to suggest these fatty acids could have urate lowering potential in humans through their uricosuric effects [ 10 ]. In a small study of 17 health men aged on average 60 years, consumption of 700 mg of omega three fatty acids (260 mg DHA and 260 mg EPA) and strength training for three months resulted in a statistically significant reduction in serum urate; pre median (range) 0.37 (0.27–0.63)mmol/l and post 0.36 (0.24–0.48) mmol/l; p = 0.017 [ 11 ]. In another small study of healthy young people consumption of 2 g fish oil daily (each 1 g capsule containing 490 mg DHA and 98 mg EPA) for eight weeks led to a significant reduction in serum urate; mean (SD) baseline 0.347 (0.025) mmol/l; week four 0.260 (0.017) mmol/l and week eight 0.308 (0.018) mmol/l p < 0.05 [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial

et al. 2022

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Objectives To determine the effect of omega-three supplementation with fish oil on serum urate, weight and body mass index (BMI) in people with gout. Methods A pilot 6-month, randomized, open-label clinical trial was undertaken in people with gout with serum urate ≥ 0.36 mmol/l. Forty participants were randomized to receive 6.2 g omega-3 fish oil daily or no fish oil for 24 weeks. Blood was obtained monthly for serum urate and red cell EPA (20:5n-3) DHA (22:6n-3) were measured using a blood spot collection system. Results There was no statistically significant difference in the mean (SEM) decrease in serum urate between baseline and week 24 between randomized groups: fish oil − 0.021 (0.02) mmol/l versus control − 0.006 (0.02) mmol/l. There was no significant difference in change in weight or BMI between baseline and week 24 between randomized groups. There was a statistically significant correlation between red cell omega-three concentrations and the total number of flares per participant between week 12 and week 24; total omega-three r = − 0.75 (p ≤ 0.001), EPA r = − 0.75 (p ≤ 0.001) and DHA r = -0.76 (p ≤ 0.001). In the omega-three fish oil group four participants reported gastrointestinal adverse effects definitely or probably related to the omega-three supplementation. Conclusions The lack of untoward effect of omega three fish oil supplementation on serum urate and BMI together with the relationship between higher omega-three concentrations and lower gout flares supports the development of further adequately powered clinical trials to determine the role of omega-three supplements as prophylaxis against gout flares in people starting urate lowering therapy. Clinical trial registration ACTRN12617000539336p Registered 13/04/2017.

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Effect of Omega-3 and Vitamins E + C Supplements on the Concentration of Serum B-Vitamins and Plasma Redox Aminothiol Antioxidant Status in Elderly Men after Strength Training for Three Months

Cited by 5 publications

References 56 publications

Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber

Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber

Association between Dietary Fat Intake and Hyperuricemia in Men with Chronic Kidney Disease

Effect of omega-three supplementation on serum urate and gout flares in people with gout; a pilot randomized trial

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