Effect of oleoyl glycine and oleoyl alanine on lithium chloride induced nausea in rats and vomiting in shrews

Rock, Erin M.; Limebeer, Cheryl L.; Smoum, Reem; Mechoulam, Raphael; Parker, Linda A.

doi:10.1007/s00213-021-06005-4

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…OlGly produced positive effects in a mouse model of mTBI and protective effects in an in vitro model of Parkinson's disease [11,12]. Both OlGly and OlAla also attenuated nausea and vomiting in lithium chloride-induced gaping in rats and vomiting in shrews [13,14]. OlGly has been assessed in preclinical models of morphine, nicotine, cocaine, and alcohol dependence [3,5,15,16].…”

Section: Introductionmentioning

confidence: 99%

High‐performance liquid chromatography‐tandem mass spectrometry method for the analysis of N‐oleoyl glycine and N‐oleoyl alanine in brain and plasma

Karin,

Mustafa,

Lichtman

et al. 2023

J of Separation Science

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Interest has increased in the role of N‐acyl amino acids in a variety of disease states and as potential pharmacotherapies. Recently, N‐oleoyl glycine and N‐oleoyl alanine have shown promise in reducing the rewarding effects of drugs of abuse and alleviating withdrawal signs in rodent models. Previously published methods for the quantitation of these analytes by high‐performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) in tissue were part of extensive lipidomic panels which may result in limited sensitivity and selectivity and also reported low recovery. Presented is a method for the extraction and HPLC‐MS/MS analysis of N‐oleoyl glycine and N‐oleoyl alanine. The bias and precision of the assay were determined to be within ± 20%. The method was shown to be reliable and robust, with over 90% recovery for the low‐level analytes. Increasing concentrations of N‐oleoyl glycine and N‐oleoyl alanine were quantitated in mouse brain and plasma following exogenous administration. This method was developed to serve to support studies investigating the pharmacokinetics and involvement of N‐oleoyl glycine and N‐oleoyl alanine in drug dependence and other diseases.

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Section: Introductionmentioning

confidence: 99%

High‐performance liquid chromatography‐tandem mass spectrometry method for the analysis of N‐oleoyl glycine and N‐oleoyl alanine in brain and plasma

Karin,

Mustafa,

Lichtman

et al. 2023

J of Separation Science

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show abstract

“…As the lack of vomiting reflex, varieties of behavioral measurements have been widely used to assess multi-dimensional responses of MS in rodents. Conditioned gaping response that can be elicited during exposure to a context previously paired with nauseant agents or provocative motion can be alleviated by corresponding anti-emetic and anti-MS drugs, making it plausible to serve as a rat model of conditioned nausea (Limebeer et al, 2008 ; Parker, 2014 ; Zhou et al, 2017 ; Qi et al, 2019 ; Rock et al, 2022 ). In addition, defecation response and decreased spontaneous locomotion activity were also observed in rats and mice exposed to whole-body rotation (Ossenkopp and Frisken, 1982 ; Ossenkopp et al, 1994 ; Yu et al, 2007 ; Limebeer et al, 2008 ; Morita et al, 2017 ; Wang et al, 2017 ; Deshetty et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Stroboscopic lighting with intensity synchronized to rotation velocity alleviates motion sickness gastrointestinal symptoms and motor disorders in rats

Mao

Pan²,

Shuhua³

et al. 2022

Front. Integr. Neurosci.

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Motion sickness (MS) is caused by mismatch between conflicted motion perception produced by motion challenges and expected “internal model” of integrated motion sensory pattern formed under normal condition in the brain. Stroboscopic light could reduce MS nausea symptom via increasing fixation ability for gaze stabilization to reduce visuo-vestibular confliction triggered by distorted vision during locomotion. This study tried to clarify whether MS induced by passive motion could be alleviated by stroboscopic light with emitting rate and intensity synchronized to acceleration–deceleration phase of motion. We observed synchronized and unsynchronized stroboscopic light (SSL: 6 cycle/min; uSSL: 2, 4, and 8 cycle/min) on MS-related gastrointestinal symptoms (conditioned gaping and defecation responses), motor disorders (hypoactivity and balance disturbance), and central Fos protein expression in rats receiving Ferris wheel-like rotation (6 cycle/min). The effects of color temperature and peak light intensity were also examined. We found that SSL (6 cycle/min) significantly reduced rotation-induced conditioned gaping and defecation responses and alleviated rotation-induced decline in spontaneous locomotion activity and disruption in balance beam performance. The efficacy of SSL against MS behavioral responses was affected by peak light intensity but not color temperature. The uSSL (4 and 8 cycle/min) only released defecation but less efficiently than SSL, while uSSL (2 cycle/min) showed no beneficial effect in MS animals. SSL but not uSSL inhibited Fos protein expression in the caudal vestibular nucleus, the nucleus of solitary tract, the parabrachial nucleus, the central nucleus of amygdala, and the paraventricular nucleus of hypothalamus, while uSSL (4 and 8 cycle/min) only decreased Fos expression in the paraventricular nucleus of hypothalamus. These results suggested that stroboscopic light synchronized to motion pattern might alleviate MS gastrointestinal symptoms and motor disorders and inhibit vestibular-autonomic pathways. Our study supports the utilization of motion-synchronous stroboscopic light as a potential countermeasure against MS under abnormal motion condition in future.

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N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice

Karin,

Mustafa,

Poklis

et al. 2024

Drug and Alcohol Dependence

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Effect of oleoyl glycine and oleoyl alanine on lithium chloride induced nausea in rats and vomiting in shrews

Cited by 4 publications

References 25 publications

High‐performance liquid chromatography‐tandem mass spectrometry method for the analysis of N‐oleoyl glycine and N‐oleoyl alanine in brain and plasma

High‐performance liquid chromatography‐tandem mass spectrometry method for the analysis of N‐oleoyl glycine and N‐oleoyl alanine in brain and plasma

Stroboscopic lighting with intensity synchronized to rotation velocity alleviates motion sickness gastrointestinal symptoms and motor disorders in rats

N-oleoyl alanine attenuates nicotine reward and spontaneous nicotine withdrawal in mice

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