Effect of oestrogen on<i>Mycobacterium avium</i>complex pulmonary infection in mice

Tsuyuguchi, Kazunari; Suzuki, Katsuhiro; Matsumoto, Hisako; Tanaka, Eisaku; Amitani, Ryoichi; Kuze, Fumiyuki

doi:10.1046/j.1365-2249.2001.01474.x

Cited by 103 publications

(71 citation statements)

References 29 publications

(42 reference statements)

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“…This appears to be one of the characteristics of pulmonary MAC infection without comorbidity [6][7][8]. Although the mechanism is unknown, changes in hormonal balance accompanied with ageing might be involved in the development of the disease [34]. The NRAMP1 polymorphism showed a relatively strong association with MAC infection where there is no predisposing condition or in cases where the main lesion is limited to the right middle lobe or lingular segment of the lung.…”

Section: Discussionmentioning

confidence: 93%

Pulmonary Mycobacterium avium complex infection: association with NRAMP1 polymorphisms

Tanaka

Shojima²,

Matsushita³

et al. 2007

European Respiratory Journal

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The present study aimed to elucidate risk factors for nonimmunocompromised pulmonary Mycobacterium avium complex (MAC) infection.Epidemiological data and variations of candidate genes for mycobacterial diseases were analysed in 111 patients with pulmonary MAC infection. Four polymorphisms of the human natural resistance-associated macrophage protein (NRAMP)1 gene, the 59(GT)n, 469+14 G/C, D543N and the 39untranslated region (3'TGTG) insertion/deletion, were genotyped using PCR-based methods. Fok I and Taq I polymorphisms of the vitamin D receptor gene and -221 X/Y and codon 54 A/B polymorphisms of the mannose binding lectin gene were also evaluated.Females were more susceptible to MAC infection mainly affecting the right middle lobe or lingular segment of the lung. Patients' residence at the onset of the disease was distributed evenly irrespective of a waterfront or city water supply system. As compared with homozygotes for major alleles of the D543N and TGTG insertion/deletion polymorphism of the NRAMP1 gene, heterozygotes containing minor alleles were less often observed in MAC cases than in controls. This genetic effect was more significant in patients without comorbidity but not in patients with comorbidity. Other polymorphisms did not show any association with the MAC infection.The human natural resistance-associated macrophage protein 1 gene might be involved in susceptibility to pulmonary Mycobacterium avium complex infection.

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Section: Discussionmentioning

confidence: 93%

Pulmonary Mycobacterium avium complex infection: association with NRAMP1 polymorphisms

Tanaka

Shojima²,

Matsushita³

et al. 2007

European Respiratory Journal

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“…A higher frequency of exposure to TB in men and other gender-specific factors might also influence antigen-specific antibody responses. Sex steroid hormones have been suggested to play a protective role against mycobacterial infection (27,28), but their role remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antigen-Specific Immunoglobulin G Responses in Pulmonary Tuberculosis Patients and Contacts

et al. 2015

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dThis study aimed to evaluate the serodiagnostic potential of immunoglobulin G (IgG) responses to Mycobacterium tuberculosis antigens in pulmonary tuberculosis (TB) patients, recent TB contacts with latent TB infection (LTBI), and healthy subjects. Infections were assessed using tuberculin skin tests, QuantiFERON-TB Gold In-Tube tests, drug susceptibility testing, and molecular genotyping of clinical isolates. Serum IgG responses to selective M. tuberculosis antigens, including the 38-kDa and 16-kDa antigens, lipoarabinomannan (LAM), and recombinant early secreted antigen target 6 kDa (ESAT-6) and culture filtrate protein 10 kDa (CFP-10), were determined. We found that the serum IgG responses to all antigens might differentiate between active TB and LTBI, with LAM having the highest diagnostic value (area under the curve [AUC] of 0.7756, P < 0.001). Recurrent TB cases showed significantly higher IgG responses to 38 kDa, CFP-10 (P < 0.01), and LAM (P < 0.05) than new cases, and male patients had higher levels of antigen-specific IgG than females (P < 0.05). Conversely, drug resistance and patient body mass index did not affect IgG responses (P > 0.05). LAM-specific IgG responses differentiated between acid-fast bacillus (AFB) smearpositive and -negative patients (P < 0.01), whereas antigen-specific IgG responses did not vary with the M. tuberculosis genotype (P > 0.05). Significantly higher IgG responses to 38 kDa and 16 kDa were observed in AFB smear-negative patients than in controls. These results suggest that assessment of serum IgG responses to selective purified M. tuberculosis antigens may help improve the diagnosis of active TB, particularly for sputum smear-negative patients or recurrent cases, and these may also help to differentiate between active TB and LTBI.

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“…During the early years of menopause (within 10 years), the serum level of macrophage colony-stimulating factor decreases significantly, but hormone replacement therapy restores it (11). In an experimental model, estrogen protects mice from M. avium infection, mainly through augmenting macrophage's functions (18). Currently, we are examining estrogen's effect on macrophages against M. intracellulare.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance and Epidemiologic Analyses of Mycobacterium avium and Mycobacterium intracellulare among Patients without AIDS

Han¹,

Tarrand²,

Infante

et al. 2005

J Clin Microbiol

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The clinical significance and prevalence of Mycobacterium avium and Mycobacterium intracellulare were analyzed in a cohort of 7,472 patients who, from 1999 to 2003, sought care at the University of Texas M.D. Anderson Cancer Center, Houston, and had cultures performed for mycobacteria. Patients were stratified for age, sex, and underlying diseases, and bacteria were identified by 16S rRNA gene sequencing. M. avium was isolated in 62 (0.83%) of 7,472 patients and M. intracellulare in 65 (0.87%). Clinically, only 10 of the 62 (16.2%) patients with M. avium had probable to definite evidence of infection, whereas the majority (83.8%) had weak evidence of infection. Sex and age did not affect the isolation or infection of M. avium. Hematological tumors predisposed to M. avium colonization but not infection. In contrast, 41 of the 65 (63.1%) patients with M. intracellulare had probable to definite infection, a level much higher than those with M. avium (P < 0.001). M. intracellulare was more prevalent in women (1.33% of 3,311) than in men (0.50% of 4,161) (P < 0.001), and underlying diseases had no effect in women. Men with lung cancer had a higher prevalence (1.37%) than men without (0.34%) (4.0-fold; P < 0.001), but it was similar to that in women. A marked age trend for the isolation of M. intracellulare among women was noted: 0.27% (1-fold) for ages of <50 years, 0.85% (3.1-fold) for ages 50 to 59 years, 1.50% (5.6-fold) for ages 60 to 69 years, and 3.74% (13.9-fold) for ages >70 years (trend, P < 0.001). The combined rate for women >50 was 1.86% (95% confidence interval [1.30 to 2.42%]) (6.9-fold). Together, these results suggest that, among non-AIDS patients, M. intracellulare is more pathogenic and tends to infect women increasingly beyond menopause (age >50 years) regardless of underlying disease. The prevalence rate of 1.86% in postmenopausal women suggests the need to further investigate the public health significance of M. intracellulare.Mycobacterium avium and Mycobacterium intracellulare are slow-growing, nontuberculous mycobacterial (NTM) species that, due to similar biochemical characteristics, are usually grouped in the Mycobacterium avium-M. intracellulare complex (MAIC). The organisms are probably the most significant NTM associated with human diseases, causing disseminated infection in patients with AIDS, nodular bronchiectasis and other pulmonary infections, lymphadenitis, and skin infection (10).Although infrequently differentiated in the literature, M. avium and M. intracellulare exhibit significantly different pathogenicity and biology, as suggested by the following. First, the vast majority (Ͼ95%) of AIDS-related MAIC infections are due to M. avium, not M. intracellulare, and the M. avium infection typically occurs when the CD4 cell count falls to less than 0.05 ϫ 10 9 /liter (7, 10). Thus, deficiency in cellular immunity is an infection risk for M. avium but not for M. intracellulare. From a microbiology standpoint, the term MAIC in AIDS is obsolete (9). Second, nodular bronchiectasis caused b...

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Effect of oestrogen onMycobacterium aviumcomplex pulmonary infection in mice

Cited by 103 publications

References 29 publications

Pulmonary Mycobacterium avium complex infection: association with NRAMP1 polymorphisms

Pulmonary Mycobacterium avium complex infection: association with NRAMP1 polymorphisms

Evaluation of Antigen-Specific Immunoglobulin G Responses in Pulmonary Tuberculosis Patients and Contacts

Clinical Significance and Epidemiologic Analyses of Mycobacterium avium and Mycobacterium intracellulare among Patients without AIDS

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