Effect of octreotide on cell-cycle kinetics and serum carcinoembryonic antigen level in hepatic metastases of colonic adenocarcinoma

Abstract

AIM:To study the inhibitory e��ect o� somatostatin analogue (octreotide) on tumor growth. METHODS:The influence of cell-cycle kinetics on hepatic metastases o� BALB/c mice colonic adenocarcinoma (CT26) with octreotide treatment in vivo was investigated by flow cytometry. The serum carcinoembryonic antigen (CEA) levels were also determined. RESULTS:The results showed that the proli�erative index (PI) and the S-phase �raction in hepatic tumors o� mice treated with octreotide decreased markedly and that the G0/G1 serum CEA phase �rac-tion increased significantly in comparison with the control (P < 0.01). A�ter administration o� octreotide, the serum CEA levels were also lower than those in the control group. The incidence o� liver metastases in the treated group was lower than that in the control. The body weight loss in the mice was slower and survival was longer in the treated group than in the control group. Furthermore, the changes in PI and the �raction distribution o� S-phase or G0/G1-phase in cell cycle were closely related to the serum CEA levels. CONCLUSION:Octreotide may be use�ul �or inhibiting the hepatic metastases o� colonic carcinoma.