Effect of octanal on the mycelial growth of Penicillium italicum and P. digitatum

Tao, Nengguo; Jia, Lei; Zhou, Haien; He, Xinguang

doi:10.1007/s11274-013-1539-2

Cited by 27 publications

(18 citation statements)

References 25 publications

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“…DEM (6.25 µg mL −1 ) cause heavy damage to mycelium plasma membrane of P. italicum , leading to spillage of intracellular macromolecular cytoplasmic components into the extracellular suspensions through damaged sites. These findings indicated that DEM can induce damage to the mycelium plasma membrane of P. italicum and is mimicking the reports for various other antifungal agents like citral, octanal, and pinocembrin that kills P. italicum and reduces blue mold in citrus fruits [8,9,11,36]. Many related studies stated that P. digitatum induced green molds in citrus fruits and were also reduced in similar mechanisms by using α-terpineol, β-carbolines, citral, octanal, and citronellal [26,30,31,37].…”

Section: Discussionsupporting

confidence: 67%

“…A similar study reported about 90% MGI against Alternaria solani in tomatoes, Cercospora arachidicola in peanuts, Physalospora piricola in apples, and Cladosporium cucumerium in cucumbers when treated with DEM at 50 µg mL −1 [35]. The DEM showed the lowest MIC value against P. italicum in comparation with pinocembrin (400 µg mL −1 ), octanal (64.11 µg mL −1 ), and citral (76.12 µg mL −1 ) in previous studies [8,9,11]. DEM treatment (6.25 µg mL −1 ) significantly reduced the spore germination (4.37%) of P. italicum brought lower than 5%.…”

Section: Discussionmentioning

confidence: 99%

“…DEM treatment (6.25 µg mL −1 ) significantly reduced the spore germination (4.37%) of P. italicum brought lower than 5%. Few natural antifungal agents such as octanal and citral, showed a complete inhibition of mycelial growth of P. italicum when added to the PDA medium at 0.5 µL mL −1 [8,9]. Accordingly, green mold caused by P. digitatum on citrus fruit, the spore germination, and mycelial growth were also completely inhibited by the addition of 0.5 µL mL −1 octanal, 3.2 µL mL −1 citronellal and 8.0 µL mL −1 cinnamaldehyde to PDA plates [25,26,31].…”

Section: Discussionmentioning

confidence: 99%

“…Compared to chemical fungicides, plant-derived natural compounds bear no or less toxicity and are generally found to be safe, along with potential antifungal properties to control postharvest fungal rotting of fresh agricultural products [5,6]. Huge numbers of studies have reported the antifungal effects of natural antifungal compounds for controlling postharvest blue mold caused by P. italicum that seriously deteriorates citrus crop [7,8,9,10,11].…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effect of 7-Demethoxytylophorine on Penicillium italicum and its Possible Mechanism

Chen

Peng

et al. 2019

Microorganisms

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7-demethoxytylophorine (DEM) is a phenanthroindolizidine alkaloid, which is reported to be effective in inhibiting leucocytes and regulation of human immunity. However, few studies reported the inhibitory effect of DEM against plant-pathogenic fungi, particularly postharvest pathogen Penicillium italicum (P. italicum). Current studies have investigated the antifungal activity of DEM through membrane damage and energy deficit in P. italicum. The results showed that the DEM potentially inhibits the growth of P. italicum in a dose-dependent manner. In vitro (mycelial growth and spore germination) tests showed great minimal inhibitory concentration (MIC) (1.56 µg mL−1) and minimum fugicide concentration (MFC) (6.25 µg mL−1). Microscopic analyses showed that mycelial morphology of P. italicum was severely damaged following DEM treatment. Moreover, relative electrical conductivity and lysis ability assays showed that DEM treatment aids in destroying the integrity of plasma membranes that deplete reducing sugars and soluble proteins. The activity of malate dehydrogenase (MDH) and succinate dehydrogenase (SDH) demonstrated that DEM led to the disruption of TCA cycle in P. italicum mycelia. The results of this study led us to conclude that, DEM could be used as a natural antifungal agent for controlling postharvest blue mold disease of citrus fruits caused by P. italicum.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Inhibitory Effect of 7-Demethoxytylophorine on Penicillium italicum and its Possible Mechanism

Chen

Peng

et al. 2019

Microorganisms

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“…SEM examinations could reveal that rough surface and shrinkage of cells were apparent in the treated hyphae (Tao et al 2014). SEM observations also confirmed the damage that the treated hypha demonstrated bending, entwining, shriveling, collapse and disorganization, and the breakage of the hypha was clearly visible (Jiang et al 2015).…”

Section: Discussionsupporting

confidence: 54%

Antifungal activity of thymol and carvacrol against postharvest pathogens Botrytis cinerea

Zhang

et al. 2019

J Food Sci Technol

110

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Botrytis cinerea is a primary pathogen causing stem and fruit rot during pre-and post-harvest. In the present study, the main purpose was to inquire into the antifungal activity and potential mechanisms of thymol and carvacrol against B. cinerea. During the experiment, the effects of thymol and carvacrol on physical and biochemical parameters of B. cinerea were evaluated. Results indicated that thymol and carvacrol exhibited strong antifungal activity against the targeted pathogen, with minimum inhibitory concentration and minimum fungicidal concentration of 65 mg/L and 100 mg/L for thymol, and 120 lL/L and 140 lL/L for carvacrol. Thymol and carvacrol changed obviously the morphology of B. cinerea hyphae by disrupting and distorting the mycelia through scanning electron microscopy. The membrane permeability of B. cinerea hyphae was prompted with the increment of two chemical agents' concentration, as evidenced by extracellular conductivity increase, the release of cell constituent, and the decrease of extracellular pH. Furthermore, a marked decline in total lipid content of B. cinerea cells was induced by the two chemical agents, suggesting that the cell membrane structures were destructed. Therefore, present results indicated that thymol and carvacrol may be used as a good alternative to conventional fungicides against B. cinerea in controlling grey molds in horticultural products.

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Cuminaldehyde downregulates folate metabolism and membrane proteins to inhibit growth of Penicillium digitatum in citrus fruit

Reymick,

Liu,

Tan

et al. 2024

Future Postharvest and Food

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In our previous study, cuminaldehyde triggered oxidative stress to inhibit growth of Penicillium digitatum in citrus fruit. Here, we examined the molecular mechanism by which it inhibited growth of P. digitatum. Results revealed a decline in content of glutathione and catalase activity from 10 and 20 min, respectively. Transcriptome and proteome data disclosed downregulation of proteins integral to mitochondrial electron transport chain (mETC) complexes I, IV, V, and transmembrane transporters. Catalase, regulators of transcription and replication, and biosynthesis of glutathione and folate were also downregulated. These were confirmed by RT‐qPCR analysis. Reduced expression of proteins integral to mETC complexes signaled possible damage to inner mitochondrial membrane. This was confirmed by decline in mitochondrial membrane potential with a concomitant decline in cellular ATP levels. mETC Complex I activity increased from 10 min which corresponded to the onset of rise in superoxide dismutase activity. The results suggest that cuminaldehyde instigated superoxide anion radicle production initially from mitochondrial complex I, while limiting the ability of the cells to scavenge the accumulating ROS by reducing the expression of glutathione and catalase. This was possibly achieved by downregulation of folate metabolism with the associated reduced expression of transcription regulators and proteins involved in glutathione biosynthesis.

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Effect of octanal on the mycelial growth of Penicillium italicum and P. digitatum

Cited by 27 publications

References 25 publications

Inhibitory Effect of 7-Demethoxytylophorine on Penicillium italicum and its Possible Mechanism

Inhibitory Effect of 7-Demethoxytylophorine on Penicillium italicum and its Possible Mechanism

Antifungal activity of thymol and carvacrol against postharvest pathogens Botrytis cinerea

Cuminaldehyde downregulates folate metabolism and membrane proteins to inhibit growth of Penicillium digitatum in citrus fruit

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