Effect of occupational lead exposure on α- and γ-tocopherol concentration in plasma

Prokopowicz, Adam; Sobczak, Andrzej; Szuła, Magdalena; Anczyk, Edmund; Kurek, Jolanta; Olszowy, Zofia; Radek, Malgorzata; Pawlas, Natalia; Ochota, Patryk; Szołtysek-Bołdys, Izabela

doi:10.1136/oemed-2012-100979

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…Pb can participate in the generation of ROS, as well as deplete antioxidant resources in the body by interference with enzymatic and non-enzymatic defence systems, which leads to modifications of cellular components, such as proteins, lipids and DNA 24 25…”

Section: Discussionmentioning

confidence: 99%

Effect of occupational exposure to lead on new risk factors for cardiovascular diseases

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Effect of occupational exposure to lead on new risk factors for cardiovascular diseases

et al. 2016

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“…16 In a previous study, we examined lead-exposed workers for the risk of atherosclerosis by measuring various CVD biomarkers and non-enzymatic antioxidants. 17 Interestingly, in the mul- …”

Section: Study Populationmentioning

confidence: 99%

“…17 Volunteers were recruited from workers at a zinc and lead ore mine in Boleslaw Mine and Metallurgical Plant S.A. in Bukowno (southern Poland). The Biomedical Ethics Committee at the Institute of Occupational Medicine and Environmental Health in Sosnowiec reviewed and approved the study protocol.…”

Section: Study Populationmentioning

confidence: 99%

Tobacco Smoking Decreases Plasma Concentration of the Emerging Cardiovascular Risk Marker, L-homoarginine

Sobczak

Prokopowicz

Radek

et al. 2014

Circ J

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1254SOBCZAK A et al. Circulation JournalOfficial Journal of the Japanese Circulation Society http://www. j-circ.or.jp useful biomarker for detecting individuals in the early stages of kidney dysfunction and for determining their risk for developing CVD. 7 To date, most experimental and epidemiological studies have focused on the effect of tobacco smoke on ADMA levels only. The first study of the influence of tobacco smoke on ADMA levels was performed using animal models and demonstrated an increase in ADMA concentrations in the endothelial cells of rabbits after prolonged exposure to nicotine. 8 Jiang et al 9 observed a significant increase in ADMA concentrations in rat plasma following a 4-week administration of nicotine in doses of 5 mg · kg −1 · day −1 , and they suggested that nicotine models the metabolic pathway of ADMA in cells by activating the alpha7 nicotinic acetylcholine receptor. However, studies based on the culture of human endothelium-derived EAhy 926 cells produced divergent results. Incubation of cells within 48 h with condensate of tobacco smoke at concentrations of 1.0 and 10.0 mg/L n the past decade, there has been increased interest in new markers of cardiovascular diseases (CVDs). These new markers of CVD risk include 2 metabolites of L-arginine: asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively). The toxic effect of tobacco smoke is multidirectional, but the mechanism of its action is not completely clear. 1-5 One mechanism may be explained by the adverse effect of tobacco smoke on the concentration of newly discovered cardiovascular risk factors, including ADMA and SDMA, which are metabolites of L-arginine. Increased plasma concentration of ADMA, which is an endogenous inhibitor of endothelial nitric oxide (NO) synthase, is a strong and independent predictor of morbidity and overall mortality of CVD in healthy women and the general population, as well as in patients with kidney insufficiency, ischemic heart disease, peripheral vascular disease, chronic heart failure, idiopathic pulmonary hypertension, and diabetes. 6 SDMA does not inhibit NO synthase, but may be a Background: Tobacco smoking is one of the most important risk factors for cardiovascular disease (CVD) and few biomarkers have been linked to the increased risk of CVD and tobacco smoking. Tobacco smoke has been shown to elevate the plasma levels of asymmetric dimethylarginine (ADMA), a metabolite of L-arginine and an endogenous inhibitor of endothelial nitric oxide synthase. The other potential biomarker that has not been studied to date is L-homoarginine, a homolog of L-arginine. The aim of this study was to evaluate the effects of cigarette smoking on L-homoarginine and other CVD biomarkers.

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“…An increased concentration of alpha-tocopherol in the liver was found to exert a protective effect against oxidative damage in exercise-induced oxidative stress [68]. Also, Alpha-Tocopherol protects cell membranes from lipid peroxidation by superoxide radical anion and lipid peroxyl free radical scavenging [69]. Also, alpha-tocopherol was reported to reduce oxidative stress in workers exposed to lead, and the administration of alphatocopherol reversed adverse health effects of lead exposure, which induced oxidative stress [70].…”

Section: Vitamin E and Oxidative Stressmentioning

confidence: 99%

Vitamins as Antioxidants

Sinbad¹,

Folorunsho²,

Olabisi³

et al. 2019

J Food Sci Nutr Res

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Oxidative stress is a significant factor in the development of chronic diseases. An improved antioxidant potential in the body can reduce oxidative stress and prevent or improve disease conditions. Some food nutrients, especially vitamin C, E, and carotenoids are well-known antioxidants; however, other vitamins such as Vitamin K, Vitamin D, Niacin, Pyridoxine and Riboflavin that may have antioxidant potential are usually not put into consideration. This review entails studies that have investigated the antioxidant properties of other vitamins with the known antioxidants inclusive and their effect in reducing oxidative stress. The reviewed studies suggest that other vitamins possess antioxidant nature, and they can improve oxidative stress, ranging from lipid peroxidation, protein carbonylation, and reduction of advanced glycated end-products. Therefore, proper attention should be given to these neglected vitamins in research activities on oxidative stress, nutrition and the management of diseases related to oxidative stress.

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Effect of occupational lead exposure on α- and γ-tocopherol concentration in plasma

Abstract: Occupational exposure to lead is strongly correlated with the concentration of γ-tocopherol but not α-tocopherol.

Cited by 9 publications

References 34 publications

Effect of occupational exposure to lead on new risk factors for cardiovascular diseases

Effect of occupational exposure to lead on new risk factors for cardiovascular diseases

Tobacco Smoking Decreases Plasma Concentration of the Emerging Cardiovascular Risk Marker, L-homoarginine

Vitamins as Antioxidants

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