Effect of Occupational Exposure to Aflatoxins on Some Liver Tumor Markers in Textile Workers

Saad-Hussein, Amal; Beshir, Safia; Moubarz, Gehan; Elserougy, Safaa; Ibrahim, Mohamed Izham Mohamed

doi:10.1002/ajim.22162

Cited by 25 publications

(13 citation statements)

References 20 publications

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“…21,26,27 Textile workers exposed to high concentrations of airborne Aspergillus flavus had significant elevations in the urinary AFM1; the metabolite of AFB1, and the liver tumor biomarkers AFP and AFU compared to a control group, although the tumor markers were generally within normal limits. 28 In the present study, the significant elevation of the serum AFU in the bakers compared to the flourmill workers and the normal controls reflects the high risk of this occupational group of developing HCC. This finding is confirmed by the significant correlation between AFU and AFB1/Alb in the bakers.…”

Section: Discussionsupporting

confidence: 45%

Carcinogenic effects of aflatoxin B1 among wheat handlers

Saad-Hussein

Taha

Beshir

et al. 2014

International Journal of Occupational and Environmental Health

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Section: Discussionsupporting

confidence: 45%

Carcinogenic effects of aflatoxin B1 among wheat handlers

Saad-Hussein

Taha

Beshir

et al. 2014

International Journal of Occupational and Environmental Health

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“…This could be caused by the aflatoxin ability to determine the mutation of the p53 tumor suppressor gene, which in normal conditions induces the apoptosis processes [74][75][76][77] . The risk of HCC increases when the exposure occurs in the presence of HBV infection, as occurs in the Chinese population [78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96] .…”

Section: Aflatoxinsmentioning

confidence: 99%

“…A variety of chemicals comprising VCM, organic solvents, chlorinated pesticides and arsenic exert adverse effects on the liver [97] (Tables 2 and 3). [4,38,41,44] , waste operators [38,44] Group 1 [34] HCV -Health care workers [38,39,61] Group 1 [34] Aflatoxin B1 1162-65-8 Paper mill and sugar factory; poultry production; rice mill; waste management; swine industry; agri-food industry; wheat handling; textile manufacturing [77,78,[87][88][89][90][91]93,96] Group 1 [76] IARC: International Agency for Research on Cancer; CAS No. : Chemical abstract service number; HBV: Hepatitis B virus; HCV: Hepatitis C virus.…”

Section: Non-infective Risk Factors For Hepatocellular Carcinomamentioning

confidence: 99%

Hepatocellular carcinoma and the risk of occupational exposure

Rapisarda

Loreto

Malaguarnera

et al. 2016

WJH

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Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson's disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem. Core tip: Hepatocellular carcinoma (HCC) is the fifth most common human cancer. This review summarizes current knowledge regarding the occupational risk factors of HCC. In particular, we underline not only the infective but also non-infective occupational risk exposure, including chemical agents and toxic metabolites which are a major cause of liver damage.

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“…22 Viegas et al report occupational exposure to aflatoxin B1 in workers involved in poultry and swine production. 6,10 Hayes et al conducted a follow-up study on 71 Dutch oilpress workers exposed to aflatoxin primarily via the respiratory route and observed that the mortalities for total-cancer and respiratory cancer were higher than expected in the aflatoxin-exposed group.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure toAspergillusand aflatoxins among food-grain workers in India

Malik

Ali

Shahid

et al. 2014

International Journal of Occupational and Environmental Health

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Background: Aflatoxins are a metabolite of Aspergillus molds and are widespread in the natural environment. Workers who handle food grains are at increased risk of exposure to aflatoxins and subsequently certain respiratory conditions. In India, more than half of the employed population is engaged in some type of agricultural work, yet little known about the respiratory problems as a result of exposure to aflatoxins among workers who handle food grains in India. Objectives: The aim of this study was to determine the risk of occupational exposure to aflatoxins in foodgrain workers compared to workers who are not occupationally exposed to food grains. Methods: Bronchoalveolar lavage (BAL) and serum samples from 46 food-grain workers and 44 non-foodgrain workers were analyzed for the presence of aflatoxins. Microscopy and culture of BAL samples were performed to detect Aspergillus species. Results: Aflatoxins were detected in 32.6% of the food-grain workers and 9.1% of non food grain workers (P,0.01). A significant difference was also found in BAL culture for Aspergillus (P,0.01) between the two groups. About 47.8% of the food-grain workers and 11.4% of non-food-grain workers had chronic respiratory symptoms. Conclusion: Occupational exposure to aflatoxins in food-grain workers was found to be associated with the increased presence of respiratory symptoms.

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Effect of Occupational Exposure to Aflatoxins on Some Liver Tumor Markers in Textile Workers

Abstract: Exposure to fungi had a significant effect on AFM1 measurements and tumor biomarkers, especially in allergic textile workers (with the exception of the arginase biomarker), though results were generally within normal limits.

Cited by 25 publications

References 20 publications

Carcinogenic effects of aflatoxin B1 among wheat handlers

Carcinogenic effects of aflatoxin B1 among wheat handlers

Hepatocellular carcinoma and the risk of occupational exposure

Occupational exposure toAspergillusand aflatoxins among food-grain workers in India

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