Effect of occlusal contact on the rate of eruption of the rat incisor

Matĕna, V; Mrklas, L; Hajek, John

doi:10.1016/0003-9969(74)90249-0

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…In this study, the shortening treatment was employed to increase the eruption rate of incisor teeth, as previously described . In addition, the expression and activity of MMP‐2 in the odontogenic region and periodontal ligament were evaluated during this process.…”

Section: Discussionmentioning

confidence: 99%

Doxycycline reduces the expression and activity of matrix metalloproteinase‐2 in the periodontal ligament of the rat incisor without altering the eruption process

Gomes

Omar

Neves

et al. 2016

J of Periodontal Research

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Section: Discussionmentioning

confidence: 99%

Doxycycline reduces the expression and activity of matrix metalloproteinase‐2 in the periodontal ligament of the rat incisor without altering the eruption process

Gomes

Omar

Neves

et al. 2016

J of Periodontal Research

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“…In addition, when the incisor tooth is subjected to a shortening treatment, that is, an elimination of the occlusal contact, the incisor assumes a hypofunctional state in which the eruption rate is around twice that of normal eruption. This observation was already well established, has been demonstrated in the literature for decades (29,30,31,32,7) and was also observed in the present study.…”

Section: Discussionsupporting

confidence: 92%

MT1-MMP, MMP-2, MMP-9, TIMP-1,-2,-3 e a proliferação celular da região odontogenica de dentes incisivos de ratos adultos

Gomes¹

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Objectives: MT1-MMP and TIMP-2 are well known for their roles in the degradation of matrix components. However, new reports are emerging on the involvement of these molecules in cell kinetics. Doxycycline can inhibit metalloproteinase activity in different systems, but in tooth, under accelerated eruption and cell proliferation conditions, the effects of doxycycline have not been well explored. In this study, doxycycline and hypofunction were used to study the relationships between eruption rate, MT1-MMP and TIMP-2 protein expression as well as cell proliferation in the odontogenic region of the rat incisor tooth.Materials and methods: Male Wistar rats were treated with doxycycline for 14 days.Two days after the beginning the treatment, rats underwent tooth shortening to produce hypo-functional (HP) and doxycycline hypo-functional (DHP) groups. Rats with intact lower teeth maintained normal eruption and were called normofunctional (NF) or doxycycline normofunctional (DNF). In each group, eruption rates were measured, and the levels of MT1-34 MMP, TIMP-2 and Ki-67 were measured in different regions using immunostaining and western blotting. Results and conclusions:The increase of MT1-MMP and TIMP-2 expression allowed us to conclude that there is a relationship between cell proliferation and eruption rate in the HP and DHP groups, suggesting that MT1-MMP and TIMP-2 may have direct roles in increasing cell proliferation in the rat incisor tooth, as observed in other study models.

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The influence of calibrated loads upon the rate of eruption of mandibular rat incisors

Steigman¹,

Michaeli

Zajicek

1981

Archives of Oral Biology

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Effect of occlusal contact on the rate of eruption of the rat incisor

Cited by 5 publications

References 18 publications

Doxycycline reduces the expression and activity of matrix metalloproteinase‐2 in the periodontal ligament of the rat incisor without altering the eruption process

Doxycycline reduces the expression and activity of matrix metalloproteinase‐2 in the periodontal ligament of the rat incisor without altering the eruption process

MT1-MMP, MMP-2, MMP-9, TIMP-1,-2,-3 e a proliferação celular da região odontogenica de dentes incisivos de ratos adultos

The influence of calibrated loads upon the rate of eruption of mandibular rat incisors

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