Effect of Obstructive Sleep Apnea on Cardiovascular Function in Obese Youth

Wang, Hui; Slorach, Cameron; Guerra, Vitor; Parekh, Rulan S.; Hamilton, Jill; Messiha, Sandra; Tse, E.; Mertens, Luc; Narang, Indra

doi:10.1016/j.amjcard.2018.09.038

Cited by 19 publications

(15 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Forty‐three studies eligible for systematic review reported matching LVDF measures to those included in the meta‐analysis (Figure 4). 19–21,26,28,29,33,35,37,39,40,44,46,48–50,52–54,57–59,61–81 A full list of these results is given in Table S5.…”

Section: Resultsmentioning

confidence: 99%

The effect of overweight/obesity on diastolic function in children and adolescents: A meta‐analysis

et al. 2021

View full text Add to dashboard Cite

Summary Left ventricular diastolic function (LVDF) is an important marker of early cardiovascular remodelling, which has not been well summarized in young people with overweight/obesity. Weighted, random‐effects regression was used to determine the strength of associations of both body mass index (BMI) and homeostatic model assessment of insulin resistance (HOMA‐IR) with LVDF measures, adjusting for age and sex. Six databases were searched after PROSPERO registration (CRD42020177470) from inception to July 2020 for studies that compared LVDF between overweight/obesity and control groups aged ≤24 years, yielding 70 studies (9983 individuals). Quality and risk of bias were assessed using NHLBI tools, with scores of good, fair, and poor for 6, 48, and 16 studies, respectively. Increased BMI was associated with worse LVDF in all measures except early mitral inflow deceleration time, with septal early diastolic tissue peak velocity to late diastolic tissue peak velocity ratio having the strongest association (n = 13 studies, 1824 individuals; r = −0.69; P < 0.001). Elevated HOMA‐IR was also associated with worse LVDF. Although we could not determine the causality of reduced LVDF in young people, our findings should aid the development of paediatric guidelines for the assessment of LVDF and support further work to address the longitudinal consequences of childhood obesity and IR on LVDF.

show abstract

Section: Resultsmentioning

confidence: 99%

The effect of overweight/obesity on diastolic function in children and adolescents: A meta‐analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Obesity was an independent risk factor for right atrial enlargement in OSA patients of Al-Khadra et al's study (Al-Khadra et al 2018). Hui's investigation also showed that obesity and OSA are two independent risk factors for cardiac dysfunction (Hui et al 2019). The subjects' BMI was also higher in the OSA group than the control group in previous studies (Buonauro et al 2017).…”

Section: Discussionmentioning

confidence: 87%

“…OSA is a clinical disorder result from recurrent sleep apnea with symptoms of snoring, respiratory pause, sudden and frequent awaking following a respiratory interruption, morning headaches, fatigue, and daytime sleepiness (Young et al 2002;Khazaie et al 2011). OSA patients are also at risk for cardiovascular disease and stroke due to hypoxia and hypercapnia (Al-Khadra et al 2018;Li et al 2018;Hui et al 2019). Although polysomnography is the gold standard for the diagnosis of obstructive sleep apnea, history and physical examination are the simplest and most cost-effective way to detect the possibility of OSA (Khazaie et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Cardiac function and cognitive function in patients with obstructive sleep apnea

Vahedi

Khosravi

Alizadian

et al. 2021

Sleep Science Practice

View full text Add to dashboard Cite

Objectives This study was designed to evaluate echocardiographic findings in patients with obstructive sleep apnea (OSA) with cognitive impairment and compare it with the control group. Methods Sixty-seven OSA patients and 52 group of healthy controls were evaluated prospectively by Mini-Mental State Examination questionnaire and trans-thoracic echocardiography. Results The cognitive impairment and diastolic dysfunction were 19.6% (P = .002) and 18.4% (P = .016) more prevalent in OSA group compared to the control group. The mean tricuspid regurgitant gradient, pulmonary artery size, and transmitral A velocity were higher, but mean right ventricular peak systolic velocity, tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), transmitral E/A ratio, and annular E’ velocity were lower in the OSA group than the control group. Comparing the patients with and without cognitive disorders, showed significant differences regarding the size of right atrium, TAPSE and FAC (P < .05). Conclusions OSA patients need accurate cardiac examinations, early diagnosis, and interventions to prevent the progression of cardiac dysfunction, especially older male patients with higher BMI and impaired cognition. Further studies are needed to determine the exact link between the OSA, obesity, and cardiac physiology.

show abstract

“…Adiposity is also associated with increasing LV stiffness, thus can be attributed to diastolic dysfunction in patients with HFpEF [ 5 ]. However, information regarding the relationship of cardiac diastolic functions with obesity in individuals without heart failure is limited [ 16 , 17 ]. In the present study, simple regression analyses showed that BMI and visceral adiposity were each significantly associated with many of the examined parameters of LV diastolic functions.…”

Section: Discussionmentioning

confidence: 99%

“…Early detection of subclinical cardiac diastolic dysfunction is apparently a clinical priority in patients with metabolic disorders for prevention of HFpEF [ 12 ]. Limited numbers of studies have shown changes in cardiac diastolic function in prediabetes [ [13] , [14] , [15] ] and obesity [ 16 , 17 ]. Although adiposity, altered glycemic abnormalities and insulin resistance may be candidate risk factors even in the pre-heart failure period, significance of autonomic nervous functions in cardiac diastolic functions is entirely obscure.…”

Section: Introductionmentioning

confidence: 99%

Subclinical decrease in cardiac autonomic and diastolic function in patients with metabolic disorders: HSCAA study

et al. 2020

View full text Add to dashboard Cite

Heart failure due to decreased diastolic function, HFpEF, is a growing health concern with rising prevalence. We examined subclinical cardiac autonomic and diastolic functions in 605 patients with metabolic diseases classified as pre-heart failure. Presence of glucose intolerance or diabetes, or visceral adiposity was significantly associated with reduced cardiac autonomic and diastolic functions. Higher autonomic functions were significantly associated with a parameter of better cardiac diastolic function (E/A) (SDNN: r = 0.306, p < 0.01; HF: r = 0.341, p < 0.01), with the association independent of diabetes, body mass index, visceral adiposity and insulin resistance index. Thus, reduced autonomic function may be a potential predictor for decreased cardiac diastolic functions in metabolic disorders.

show abstract

Effect of Obstructive Sleep Apnea on Cardiovascular Function in Obese Youth

Cited by 19 publications

References 28 publications

The effect of overweight/obesity on diastolic function in children and adolescents: A meta‐analysis

The effect of overweight/obesity on diastolic function in children and adolescents: A meta‐analysis

Cardiac function and cognitive function in patients with obstructive sleep apnea

Subclinical decrease in cardiac autonomic and diastolic function in patients with metabolic disorders: HSCAA study

Contact Info

Product

Resources

About