Effect of Obesity on Sex Hormone Levels, Antisperm Antibodies, and Fertility After Vasectomy Reversal

Hinz, Stefan; Rais‐Bahrami, Soroush; Kempkensteffen, Carsten; Weiske, W.-H.; Miller, Kurt; Magheli, Ahmed

doi:10.1016/j.urology.2010.01.055

Cited by 37 publications

(34 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Male obesity is associated with reduced pregnancy rates and an increase in pregnancy loss in couples undergoing ART (Hinz et al, 2010;Keltz et al, 2010;Bakos et al, 2011a). Interestingly, one study noted that fertilisation rate was higher among obese men than men of normal weight for conventional in vitro fertilisation (IVF) cycles, and that there were no signifi cant associations between male BMI and poor-quality embryos or cleavage rate (Colaci et al, 2012).…”

Section: Deleterious Effects Upon Molecular Mechanisms In Spermmentioning

confidence: 99%

“…One study reports that in patients seeking treatment for male infertility, there has been a three-fold increase in the prevalence of obesity (Kasturi et al, 2008). While current data remains highly confl icting, mounting evidence indicates that male obesity is associated with an increased time to conception, reduced pregnancy rates and an increase in pregnancy loss in couples undergoing assisted reproductive technology (ART) (Nguyen et al, 2007;Ramlau-Hansen et al, 2007;Hinz et al, 2010;Keltz et al, 2010;Bakos et al, 2011a).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility

et al. 2015

View full text Add to dashboard Cite

Worldwide obesity rates have nearly doubled since 1980 and currently over 10% of the population is obese. In 2008, over 1.4 billion adults aged 20 years and older had a body mass index or BMI above a healthy weight and of these, over 200 million men and nearly 300 million women were obese. While obesity can have many ramifications upon adult life, one growing area of concern is that of reproductive capacity. Obesity affects male infertility by influencing the hypothalamic-pituitary-gonadal axis, thus causing detrimental effects upon spermatogenesis and subsequent fertility. In particular, evidence indicates that excess adipose tissue can alter the relative ratio of testosterone and oestrogen. Additional effects involve the homeostatic disruption of insulin, sex-hormone-binding-globulin, leptin and inhibin B, leading to diminished testosterone production and impairment to spermatogenesis. Aberrant spermatogenesis arising from obesity is associated with downstream changes in key semen parameters, defective sperm capacitation and binding, and deleterious effects on sperm chromatin structure. More recent investigations into trans-generational epigenetic inheritance further suggest that molecular changes in sperm that arise from obesity-related impaired spermatogenesis, such as modified sperm RNA levels, DNA methylation, protamination and histone acetylation, can impact upon the development of offspring. Here, we summarise our current understanding of how obesity exerts influence over spermatogenesis and subsequent fertility status, and make recommendations for future investigative research.

show abstract

Section: Deleterious Effects Upon Molecular Mechanisms In Spermmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Consequently, the rates of male obesity in reproductive age men has nearly tripled since the 1970s (33). Recent studies in both humans and other species shows that male obesity impairs male reproductive potential, affecting both the molecular and physical structure of sperm (1,10,16,20,21,34,35,38,45,47,50,63,75,79) and the health of the developing fetus and subsequent offspring (9,24,42,55,59). …”

mentioning

confidence: 99%

“…Furthermore, proteins regulating acetylation and DNA damage repair systems are also altered in obese mice (63). High levels of reactive oxygen species (ROS) and DNA damage in sperm have also been associated with increased patient body mass index (BMI) in humans (16,47,79), with increased levels of IgA anti-sperm antibodies also reported in obese men (34). However, the reversibility of the effects to the molecular and physical structure of sperm resultant from obesity has never been studied.…”

mentioning

confidence: 99%

Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function

Palmer¹,

Bakos

Owens³

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

194

181

View full text Add to dashboard Cite

Palmer NO, Bakos HW, Owens JA, Setchell BP, Lane M. Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function. Am J Physiol Endocrinol Metab 302: E768 -E780, 2012. First published January 17, 2012; doi:10.1152/ajpendo.00401.2011.-Male obesity is associated with reduced sperm motility and morphology and increased sperm DNA damage and oxidative stress; however, the reversibility of these phenotypes has never been studied. Therefore, the aim of this study was to assess the reversibility of obesity and its associated sperm physiology and function in mice in response to weight loss through diet and exercise. C57BL6 male mice (n ϭ 40) were fed either a control diet (CD; 6% fat) or a high-fat diet (HFD; 21% fat) for 10 wk before allocation to either diet and/or swimming exercise interventions for 8 wk. Diet alone reduced adiposity (1.6-fold) and serum cholesterol levels (1.7-fold, P Ͻ 0.05), while exercise alone did not alter these, but exercise plus diet also improved glucose tolerance (1.3-fold, P Ͻ 0.05). Diet and/or exercise improved sperm motility (1.2-fold) and morphology (1.1-fold, P Ͻ 0.05), and reduced sperm DNA damage (1.5-fold), reactive oxygen species (1.1-fold), and mitochondrial membrane potential (1.2-fold, P Ͻ 0.05) and increased sperm binding (1.4-fold) (P Ͻ 0.05). Sperm parameters were highly correlated with measures of glycemia, insulin action, and serum cholesterol (all P Ͻ 0.05) regardless of adiposity or intervention, suggesting a link between systemic metabolic status and sperm function. This is the first study to show that the abnormal sperm physiology resulting from obesity can be reversed through diet and exercise, even in the presence of ongoing obesity, suggesting that diet and lifestyle interventions could be a combined approach to target subfertility in overweight and obese men. lifestyle interventions; fertility and metabolism OBESITY IS A GLOBAL HEALTH PROBLEM that is reaching epidemic proportions, with 1.6 billion adults classified as overweight and 400 million adults classified as obese worldwide (60). Consequently, the rates of male obesity in reproductive age men has nearly tripled since the 1970s (33). Recent studies in both humans and other species shows that male obesity impairs male reproductive potential, affecting both the molecular and physical structure of sperm (1,10,16,20,21,34,35,38,45,47,50,63,75,79) and the health of the developing fetus and subsequent offspring (9,24,42,55,59).Although fertility is not always impaired in obese men, almost 80% of men that present to fertility clinics are classified as either overweight or obese, suggestive of an interaction between obesity and sperm function (9). There is a negative impact of male obesity on standard semen parameters, including motility, count, and hormone abundance, such as testosterone and inhibin B (1,5,16,18,21,22,32,35,37,45,47,52,62,69,85). Further studies have reported reduced pregnancy success and live birth outcomes after IVF treatment in overweight and...

show abstract

“…Most often, it has been noted that the high-quality semen is usually produced by people who have frequent sex number of times. The semen they produce contains undestroyed DNA and is very fertile (50). Most men who regularly have sex are likely to impregnate ladies who are in their ovulation period since their sperms are not stale and are more mobile (51).…”

Section: Abstinence and Sperm Dna Integritymentioning

confidence: 99%

Sexual Abstinence and Sperm Quality

AlAwlaqi¹,

Hammadeh²

2017

IJWHR

View full text Add to dashboard Cite

Background: Previous research has documented that sexual abstinence can improve sperm quality. Sexologists have reported that sperms stored in a latex condom decrease at a rate of 60% per minute. Objective: The objective of the current review is to explore the relationship between sexual abstinence duration and other factors that affect standard and substandard semen production. Design: A scientific review of published literature. Main Outcome Measure: Specific focus is to discuss how sexual abstinence behaviours relate to the production, quality and efficiency of sperms and semen in relation to the different characteristics such as duration of abstinence, age, and psychological behaviours. The study will also seek to verify if there is a link between sexual abstinence and semen production or what triggers semen production in men. Results: From the reviewed literature, data analysis on oligozoospermic samples indicated a peak motility of 30% after 1 day of abstinence. After 2 days of abstinence, the recorded average percentage of the normal sperm morphologies among the moderate and mild oligozoospermic samples ranged from 7% to 8.5%. The increase of the normal sperm morphology was statistically significant (P < 0.003) and sperm motility (P < 0.001) that were in line with the average percentage production of 7.5% and 31.9%, respectively. The significant sperm production was recorded between day 3 and day 8 of abstinence. Conclusion:The data obtained supports the literature on abstinence in facilitating male infertility treatment. Thus, the data argues that so as to present the best semen samples for fertility treatment, men should collect semen sample after 3-8 days of abstinence as recommended by the World Health Organization (WHO). Patients that present normal sperms give sperm donations for cryopreservation ought to be informed not to exceed the 10-day abstinence duration as the quality of the sperms is compromised.

show abstract

Effect of Obesity on Sex Hormone Levels, Antisperm Antibodies, and Fertility After Vasectomy Reversal

Cited by 37 publications

References 21 publications

Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility

Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility

Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm function

Sexual Abstinence and Sperm Quality

Contact Info

Product

Resources

About