Effect of Obesity on Mortality in Pulmonary Arterial Hypertension: A Retrospective Analysis

Badri, Marwan; Saeed, Wajeeha; Lahoti, Ankush; Salamon, Jason N.; Gnall, Eric; Zolty, Ronald; Sardar, Rizwan

doi:10.1016/s0735-1097(12)61591-5

Cited by 2 publications

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“…Interestingly, conflicting effects of obesity were seen in patients diagnosed with pulmonary arterial hypertension (PAH) after first or third year of PAH diagnosis. The mortality in the first year after PAH diagnosis was higher, while it was significantly lower in obese patients after third year of diagnosis [6]. The role of obesity in PH is still unclear suggesting it neither as a friend nor as a foe.…”

Section: Introductionmentioning

confidence: 95%

Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

et al. 2020

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Background Obesity and pulmonary hypertension (PH) share common characteristics, such as augmented inflammation and oxidative stress. However, the exact role of obesity in the pathology of PH is largely uninvestigated. Therefore, we have hypothesized that in the context of obesity the gender difference may have influence on development of PH in animal models of this disease. Methods Animal experiments were conducted in monocrotaline (MCT) and chronic hypoxia (HOX) models of PH. Lean and obese Zucker rats or B6 mice of both genders were used for MCT or HOX models, respectively. Echocardiography, hemodynamic measurements, histology and immuno-histochemistry were performed to analyze various parameters, such as right ventricular function and hypertrophy, hemodynamics, pulmonary vascular remodeling and lung inflammation. Results Both lean and obese male and female Zucker rats developed PH after a single MCT injection. However, negligible differences were seen between lean and obese male rats in terms of PH severity at the end stage of disease. Conversely, a more prominent and severe PH was observed in obese female rats compared to their lean counterparts. In contrast, HOX induced PH in lean and obese, male and female mice did not show any apparent differences. Conclusion Gender influences PH severity in obese MCT-injected rats. It is also an important factor associated with altered inflammation. However, further research is necessary to investigate and reveal the underlying mechanisms.

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Section: Introductionmentioning

confidence: 95%

Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

et al. 2020

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“…In Colombia, it is estimated that between 0.1 and 0.2% of deaths occur as a result of rheumatic disease [5] . Delay in the treatment of MS leads to complications like atrial fibrillation and pulmonary hypertension [6][7][8] . In 1984, Inoue et al described the first percutaneous mitral balloon valvuloplasty (PMBV) and since then, the Inoue technique has been shown to produce excellent hemodynamic results in patients with severe rheumatic mitral stenosis [9] .…”

Section: Introductionmentioning

confidence: 99%

Long-term Outcomes after Percutaneous Mitral Valvuloplasty in Colombia, South America

Saeed¹

2015

JHC

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Objective: To evaluate the long term clinical results of percutaneous mitral balloon valvuloplasty in patients with rheumatic mitral stenosis in Colombia, South America. Background: In 1993, Colombia, South America began a National Mitral Balloon Valvuloplasty Registry. This multicenter database was designed to establish the longterm safety and efficacy of percutaneous mitral valvuloplasty, as well as rate of restenosis. Methods: Between January 1993 and December 2011, 182 patients >18 years old were treated for rheumatic mitral stenosis with percutaneous valvuloplasty in two centers in Colombia, South America. Clinical, echocardiographic and hemodynamic data were stored in an electronic database. The Inoue Balloon technique was used in 99% of patients. The longest follow-up period was 15 years. Results: 182 patients were included; women (89%), hypertension (19%), dyslipidemia (1.6%), smoking (8.8%), diabetes (5.5%) and renal failure (1%). Forty-six patients (25.7%) were NYHA functional class III-IV. Procedure related mortality was 1.09% (2 patients). Fourteen patients (7.69%) had significant post procedure mitral insufficiency (grades III-IV); 4 patients (2.19%) had cardiac tamponade and 6 patients (3.3%) had vascular site related complications. The survival rate at 12 months was 96%. At 50 months, 60.7% of patients were alive and free of mitral surgery and repeated mitral valvuloplasty. The percentage of severe restenosis of mitral valve was 4.8%, 19.2%, 15.2% at one, five and 10 years of follow-up. Conclusions: Percutaneous mitral valvuloplasty using the Inoue balloon technique improves the hemodynamic profile of severe mitral stenosis. Long-term follow-up suggest that it is a safe alternative to mitral valve surgery in well selected patients.

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Effect of Obesity on Mortality in Pulmonary Arterial Hypertension: A Retrospective Analysis

Cited by 2 publications

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Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

Influence of gender in monocrotaline and chronic hypoxia induced pulmonary hypertension in obese rats and mice

Long-term Outcomes after Percutaneous Mitral Valvuloplasty in Colombia, South America

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