Effect of Oat Bran on Lithogenic Index of Bile and Bile Acid Metabolism

Arffmann, S; Højgaard, Liselotte; Giese, Birgitte; Krag, E

doi:10.1159/000198986

Cited by 7 publications

(6 citation statements)

References 11 publications

(13 reference statements)

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“…Acidification of the colon might inhibit the 7a-dehydroxylation of primary BA and the formation of secondary BA [27]. It has also been reported that oat bran seems to influence the metabolism of BA [29]. This is in accordance with the findings that short chain fatty acids (SCFA), which are the main end products of the bacterial breakdown of fibres, are rapidly absorbed from the human colon (281.…”

Section: Fibres and Faecal Bile Acid7 In Uc 705supporting

confidence: 65%

Long-term double-blind study on the influence of dietary fibres on faecal bile acid excretion in juvenile ulcerative colitis

Ejderhamn

Hedenborg

Strandvik

1992

Scandinavian Journal of Clinical and Laboratory Investigation

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A double-blind cross-over long-term trial (18 months) with randomized supplementation with wheat fibre or ispaghula for two periods of six months, separated by a six-month wash-out period with placebo, was performed in ten patients with juvenile ulcerative colitis to study the effect on faecal bile acid (BA) excretion. All patients were in remission since 0.5-2 years and orally treated with sulphasalazine. The average intake of either fibres was 16 g day-1. Faecal samples were collected (72 h) before and after each fibre period. Faecal water were prepared by centrifugation of faeces at 15,000 g for 2 h. BA in faeces and faecal water were studied using capillary column gas-liquid chromatography-mass spectrometry. Faecal excretion of total BA were not significantly changed by the two fibres. Supplementation with wheat fibre, but not with ispaghula, decreased the faecal concentration of total BA by 43% (p < 0.05), unconjugated BA by 41% (p < 0.01), and taurine conjugated BA by 58% (p < 0.05). Addition of wheat fibre decreased the concentration of chenodeoxycholic acid by 66% (p < 0.05) and isomers of cholic acid by 51% (p < 0.05) in faeces. The mean faecal water concentration of taurine-conjugated BA decreased by 55% when wheat fibre was added (p < 0.05) and the concentration of isomers of deoxycholic acid increased by 39% when ispaghula was supplemented (p < 0.05). The ratio isomeric deoxycholic acid to deoxycholic acid in faecal water increased significantly when wheat fibre was added (p < 0.05). The percentage distribution of secondary and ketonic BA was not influenced by the dietary fibre supplementation. The concentration of BA in faeces and faecal water decreased only by wheat fibre, suggesting that it is superior in obtaining an affect on faecal BA concentration.

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Section: Fibres and Faecal Bile Acid7 In Uc 705supporting

confidence: 65%

Long-term double-blind study on the influence of dietary fibres on faecal bile acid excretion in juvenile ulcerative colitis

Ejderhamn

Hedenborg

Strandvik

1992

Scandinavian Journal of Clinical and Laboratory Investigation

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“…On the other hand, the adsorption of bile salts by dietary fiber has important roles such as decreased serum bile acid levels after oral administration of ispaghula [27]and altered bile acid composition in bile after oral administration of oat bran [28]. Therefore, it is important to investigate whether GBF can adsorb bile salts in vitro.…”

Section: Discussionmentioning

confidence: 99%

Germinated Barley Foodstuff Exhibits Different Adsorption Properties for Hydrophilic versus Hydrophobic Bile Acids

et al. 2001

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Background/Aims: Germinated barley foodstuff (GBF), a type of dietary fiber, exhibits therapeutic effects in ulcerative colitis (UC) patients. However, the precise mechanisms responsible for these effects are still under investigation. On the other hand, it has been suggested that bile salts in the gut lumen play an important role in the integrity of the intestinal mucosa. The aim of the present study was to investigate the ability of GBF to adsorb bile salts in vitro. Methods: The binding capacities of GBF, enzymatically digested GBF (GBF-fiber), and α-cellulose for unconjugated and conjugated bile salts were measured using Langmuir’s method. The morphology of these fibers was observed by light and fluorescence microscopy. Results: GBF adsorbed bile salts very strongly, especially hydrophobic bile salts. Even after enzymatic digestion, the GBF fiber still exhibited strong binding capacity, whereas α-cellulose exhibited very low binding capacity. Microscopically, GBF consists mainly of aleurone, a lattice-like cell wall with cytoplasm enclosed. After enzymatic digestion, the cytoplasm was also digested. Conclusion: GBF possesses a great capacity to adsorb bile salts. This may be part of the mechanism for the therapeutic effects of GBF in UC patients.

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“…Table 5 describes the fourteen studies (seventeen articles ( 35 – 51 ) ) that were carried out in participants without a history of colorectal adenomas, UC or coeliac disease. Five studies were carried out in the USA ( 36 , 37 , 39 – 41 , 43 ) , three in the UK ( 38 , 48 , 51 ) , two in Denmark ( 42 , 49 ) , two in Australia ( 44 , 50 ) and one each in Austria ( 45 – 47 ) and Sweden ( 35 ) . The number of subjects in each intervention group ranged from six to fifty (with only one study containing more than twenty-four subjects per group) and the interventions lasted between at least 10 d and 12 weeks.…”

Section: Resultsmentioning

confidence: 99%

Oats and bowel disease: a systematic literature review

et al. 2014

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Whole-grain foods such as oats may protect against colorectal cancer and have benefits on inflammatory bowel disease and coeliac disease. The present study aimed to systematically review the literature describing intervention studies that investigated the effects of oats or oat bran on risk factors for bowel disease. A literature search was conducted using Embase, Medline and the Cochrane library, which identified 654 potential articles. Thirty-eight articles describing twenty-nine studies met the inclusion criteria. Two studies carried out in participants with a history of colorectal adenomas found no effects of increased oat-bran intake on indirect risk makers for colorectal cancer. One of two interventions with oat bran in patients with ulcerative colitis showed small improvements in the patients' conditions. Most of the eleven studies carried out in adults with coeliac disease showed no negative effects of uncontaminated oat consumption. The fourteen studies carried out in volunteers with no history of bowel disease suggest that oats or oat bran can significantly increase stool weight and decrease constipation, but there is a lack of evidence to support a specific effect of oats on bowel function compared with other cereals. A long-term dietary intake of oats or oat bran could benefit inflammatory bowel disorders, but this remains to be proven. A protective effect on colorectal adenoma and cancer incidence has not yet been convincingly shown. The majority of patients with coeliac disease could consume up to 100 g/d of uncontaminated oats, which would increase the acceptability of, and adherence to, a gluten-free diet.

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Effect of Oat Bran on Lithogenic Index of Bile and Bile Acid Metabolism

Cited by 7 publications

References 11 publications

Long-term double-blind study on the influence of dietary fibres on faecal bile acid excretion in juvenile ulcerative colitis

Long-term double-blind study on the influence of dietary fibres on faecal bile acid excretion in juvenile ulcerative colitis

Germinated Barley Foodstuff Exhibits Different Adsorption Properties for Hydrophilic versus Hydrophobic Bile Acids

Oats and bowel disease: a systematic literature review

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