Effect of O3/H2O2 molar concentration ratio at different pH values on cyclophosphamide degradation

Venta, Mayra Bataller; Castro, Carlos; García, Lidia Asela Fernández; Marzo, Adaris López; Lorenzo, Eliet Véliz; Álvarez, Caridad Álvarez

doi:10.2166/aqua.2005.0038

Cited by 12 publications

(4 citation statements)

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“…4‐ketocyclophosphamide was identified as the main product of the reaction of cyclophosphamide and ozone at pH 9, by the combined use of preparative HPLC, infrared spectrum, ESI‐MS and tandem mass spectra. This compound has been reported before (Peter 1976) in other experimental conditions and also by our group at pH 7 and O 3 /H 2 O 2 molar relation ratio 3.4 (Bataller et al 2005).…”

Section: Reaction Productssupporting

confidence: 85%

“…Under the reaction conditions used, this is a logical behaviour because the ozone decomposition rate and the generation of hydroxyl radical that reacts with the substrate are augmented. The same effect was observed when hydrogen peroxide was added simultaneously during the ozonation of cyclophosphamide (Bataller et al 2005).…”

Section: Study Of the Hydrogen Peroxide Effect Addition Of Hydrogen supporting

confidence: 55%

“…Taking into account previous results obtained in the study of O 3 /H 2 O 2 –cyclophosphamide system (Bataller et al 2005), it was decided to investigate the influence of a group of parameters on the cyclophosphamide degradation rate. With that purpose an experimental design was carried out.…”

Section: Influence Of Several Physico‐chemical Parametersmentioning

confidence: 99%

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Cyclophosphamide degradation by advanced oxidation processes

Fernández¹,

Hernández²,

Bataller³

et al. 2009

Water and Environment Journal

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Cyclophosphamide is a hazardous cytostatic drug, which should be removed from wastewaters before disposals. Ozonation slowly inactivates this substance, requiring long reaction times to obtain degradation. In this paper, different advanced oxidation processes (AOPs) are studied for cyclophosphamide oxidative degradation in aqueous medium: ozone at several basic pH values, ozone/hydrogen peroxide at neutral and basic pHs with the addition of the peroxide at the beginning of ozonation. The influence of ozone concentration in the gas phase and gas flow is also discussed. Results show that, under the experimental conditions studied, the radical mechanism acting in the AOPs rapidly degrades cyclophosphamide. Additionally, second‐order rate constants kd and kOH were determined for direct (molecular) and indirect (radical) reactions. Finally, reactions were carried out with the aim of isolating and identifying some of the degradation products. From ozonation at pH 9, 4‐ketocyclophosphamide was identified as the main reaction product.

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Section: Reaction Productssupporting

confidence: 85%

Section: Study Of the Hydrogen Peroxide Effect Addition Of Hydrogen supporting

confidence: 55%

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Cyclophosphamide degradation by advanced oxidation processes

Fernández¹,

Hernández²,

Bataller³

et al. 2009

Water and Environment Journal

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“…The degradation of 5-fluorouracyl, cytarabine, azathioprine and methotrexate with ozone reported by Pe´rez-Rey et al (1999) and the degradation of cyclophosphamide by ozone under advanced oxidation process conditions reported by Bataller et al (2005) are among them. In this last article the main oxidation product was identified.…”

Section: Introductionmentioning

confidence: 93%

Ozonation of Cisplatin in Aqueous Solution at pH 9

Hernandez

Ramos

Fernández

et al. 2008

Ozone: Science & Engineering

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Ozonation of cisplatin [cis-diamminedichloroplatinum (II)] in non-buffered and buffered aqueous solutions at pH 9 was carried out at 303 K in a semi batch system at laboratory scale. The degradation of cisplatin and the formation of reaction products were analyzed by reverse phase high performance liquid chromatography. In the first two minutes of reaction practically all the initial cisplatin was depleted and only one major peak was observed in chromatograms under both experimental conditions. The structure of this main product was proposed after analysis by electrospray ionization tandem mass spectrometry (ESI-MS/MS). The mutagenicity of reaction mixture at non-buffered pH 9 was evaluated by performing Ames test. Non-mutagenic effect was observed. The second-order reaction rate constant of cisplatin with hydroxyl radical at pH 9 and 303 K was determined.

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