Effect of Nutritional Status and Changes in Protein Intake on Renal Function

Landau, Daniel; Rabkin, Ralph

doi:10.1016/b978-0-12-391934-2.00013-8

Cited by 4 publications

(6 citation statements)

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“…Comparison Between Impaired Kidney Function and Non-Impaired Kidney Function Subgroups in the Anorexia Nervosa Group 0.54 [0.14] mg/dL; P < .001; SCr/BMI: 3.6% [0.8%] vs 2.8% [1.1%]; P < .001; minimal eGFR: 112[18.5] mL/min/1.73 m 2 vs 124[26.5] mL/min/1.73 m 2 ; P < .001).The FT 3 levels, available for fewer patients in the AN group (n = 187), were lower in the IKF Vs non IKF group (mean [SD] 3.5 [0.2] pmol/L vs 4.08[1.2] pmol/L; P = .001). A similar difference was seen for minimal mean (SD) HR (44[11] beats per min vs 56[16] beats per min; P < .001). Length of hospitalization was longer in the IKF group (median 13 [IQR,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] days vs 8 [IQR,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] days; P = .03).…”

supporting

confidence: 65%

“…Nutrition plays a substantial role in renal function. 16 While GFR increases with animal protein intake, it decreases in a state of protein-energy malnutrition, as well as sodium and acid excretion and urinary concentrating ability. 17 Healthy patients fed a calorie-deficient diet demonstrate a reduction in creatinine clearance.…”

Section: Discussionmentioning

confidence: 99%

“…There was no difference in admission BMI between anorexia groups with and without kidney function impairment. Mean (SD) free T 3 levels (3.5 [0.2] pmol/L vs 4.08 [1.2] pmol/L; P < .001) and mean (SD) minimal heart rate (44 [11] beats per min vs 56 [16] beats per min; P < .001) were lower and hospital stay was longer (median, 13 [IQR,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) days vs 8 [IQR,[4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] days; P = .03) in the impaired kidney function group. The highest correlation was found between minimal heart rate and minimal eGFR (R = 0.53; P < .001).…”

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confidence: 99%

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Incidence of Impaired Kidney Function Among Adolescent Patients Hospitalized With Anorexia Nervosa

2021

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Key Points Question What is the incidence of impaired kidney function in adolescents with anorexia nervosa, and how does it correlate with body mass index and physiologic parameters of anorexia nervosa severity? Findings In this case-control study of 395 adolescent patients with recent diagnosis of anorexia nervosa, impaired kidney function was found in 36.8%. Minimal heart rate and free triiodothyronine levels showed correlation with eGFR but not with admission body mass index. Meaning Results of this case-control study suggest that impaired kidney function may be a better parameter of anorexia nervosa severity than body mass index.

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confidence: 65%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Incidence of Impaired Kidney Function Among Adolescent Patients Hospitalized With Anorexia Nervosa

2021

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“…70 Both renal blood flow and GFR increase by at least 30% when healthy persons transition from low to high animal protein intake, 70 whereas vegetable protein intake is not associated with changes in renal plasma flow. 71 The elevated GFR or hyperfiltration noted in obese adults is not mediated by protein intake, 72 but high animal protein intake in obese adults may heighten intraglomerular capillary pressure by vasodilating the afferent arteriole. This afferent dilation occurs due to amino acids triggering multiple humoral and local mediators that vasodilate the afferent arteriole.…”

Section: Proteinmentioning

confidence: 99%

“…This afferent dilation occurs due to amino acids triggering multiple humoral and local mediators that vasodilate the afferent arteriole. 71,[73][74][75] Afferent vasodilatation then impairs the autoregulatory response of afferent arteriole vasoconstriction in the setting of elevated systemic blood pressures. Impairment of this autoregulatory capacity enhances the transmission of elevated systemic pressures to the glomerular capillary.…”

Section: Proteinmentioning

confidence: 99%

Kidney Disease and the Westernization and Industrialization of Food

Kramer

2017

American Journal of Kidney Diseases

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The industrialization of food in the United States has led to lower prices, and families now spend a smaller percentage of their total income on food compared with past generations. The decline in prices for food commodities has led to sharp increases in food consumption, with average caloric intake in the United States now more than 500 calories higher per day compared to the 1970s. This increase in total food consumption has fueled the ongoing obesity epidemic, which in turn has likely played a role in the epidemic of end-stage renal disease during the last 2 decades. A close examination of dietary behaviors in the United States reveals high consumption of salt and animal protein, which negatively affects kidney disease progression. An interprofessional approach is necessary to address obesity, and studies are needed to identify best practices for integrating medical nutrition therapy into the long-term care of patients with chronic kidney disease.

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The Western Diet and Chronic Kidney Disease

2015

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Characteristics of the Western diet that fueled the obesity epidemic may also impact kidney disease incidence and progression. Enlarging portion sizes over the past half century has been accompanied by increased intake of protein, sodium, and processed foods while consumption of fruits and vegetables has declined. Overall dietary patterns play a strong role for chronic disease risk including chronic kidney disease. While dietary patterns high in fresh fruits and vegetables and low in red meats, such as the Mediterranean diet, decrease the risk of chronic diseases, the Western diet, characterized by high intake of red meat, animal fat, sweets, and desserts and low intake of fresh fruits and vegetables and low-fat dairy products, increases risk of chronic diseases. In this article, we review the potential mechanisms whereby several key characteristics of the typical Western diet may impact kidney disease incidence and progression. We also discuss a public health policy initiative to improve dietary choices. Reducing protein intake to the recommended daily allowance of 0.8 g/kg/day and increasing intake of fruit and vegetables and fiber may mitigate kidney disease progression and reduce risk of cardiovascular disease and mortality.

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Effect of Nutritional Status and Changes in Protein Intake on Renal Function

Cited by 4 publications

References 99 publications

Incidence of Impaired Kidney Function Among Adolescent Patients Hospitalized With Anorexia Nervosa

Incidence of Impaired Kidney Function Among Adolescent Patients Hospitalized With Anorexia Nervosa

Kidney Disease and the Westernization and Industrialization of Food

The Western Diet and Chronic Kidney Disease

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