Effect of nutritional and environmental conditions on the production of exo-polysaccharide of Agaricus brasiliensis by submerged fermentation and its antitumor activity

Fan, Leifa; Soccol, Andréa Thomaz; Pandey, Ashok; Soccol, Carlos Ricardo

doi:10.1016/j.lwt.2005.09.006

Cited by 61 publications

(44 citation statements)

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“…(Gbolagade, Fasidi, Ajayi, & Sobowale, 2006), Chinese species Pleurotus tuber-regium (Fr.) (Wu, Cheung, Wong, & Huang, 2003;Wu, Cheung, Wong, & Huang, 2004), Cordyceps militaris (Mao & Zhong, 2006) and Brazilian specie Agaricus brasiliensis (A. blazei) (Fan, Soccol, Pandey, & Soccol, 2007), no studies were found for the Portuguese species and no reports are known about the influence of the nitrogen source in the bioactive properties of wild edible mushrooms. In this work, we evaluated the effects of various nitrogen sources on the production and functional properties of Leucopaxillus giganteus mycelium.…”

Section: Introductionmentioning

confidence: 99%

Bioactive properties of the medicinal mushroom Leucopaxillus giganteus mycelium obtained in the presence of different nitrogen sources

et al. 2007

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Leucopaxillus mushroom species are used in the chemical industry for extraction of clitocybin antibiotic and particularly the edible mushroom Leucopaxillus giganteus can be found in Northeast Portugal. Nevertheless, the production of its mycelium for pharmacological applications has not been explored. Herein, the mycelium obtained in the presence of four different nitrogen sources was investigated with regard to phenol production and antimicrobial and antioxidant properties. Phenol concentration increased along the growth time as a response to the oxidative stress and therefore free radical production. Although significant differences for mycelium growth between the nitrogen sources had not been observed, (NH 4 ) 2 HPO 4 proved to be the most appropriate to increase bioactive properties, leading to the highest phenol content and lowest EC 50 and MIC values. The antimicrobial capacity was screened against Gram positive and Gram negative bacteria, and fungi. The samples selectively inhibited the growth of Gram positive bacteria, Staphylococcus aureus being the most susceptible one. Gram negative bacteria and fungi were resistant to the extracts. Antioxidant activity was calculated by the reducing power assay, the scavenging effect on DPPH radicals, and hemolysis and lipid peroxidation inhibition. Significantly negative linear regressions were established between phenols/flavonoids contents, which increased along the mycelia growth time and antioxidant activity.

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Section: Introductionmentioning

confidence: 99%

Bioactive properties of the medicinal mushroom Leucopaxillus giganteus mycelium obtained in the presence of different nitrogen sources

et al. 2007

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“…3)-glucan side branches. This fungus has been properly adapted to grow in liquid substrates, with several studies proposing its experimental optimization in SmF for the production of mycelial biomass and exopolysaccharides (Lin and Yang 2006;Fan et al 2007;Hamedi et al 2007). Examples of experimental optimization for several fungal species in SSF for the production of industrially important products have been proposed (Prakash et al 2008;Baños et al 2009).…”

Section: Preservation Of Fungal Materialsmentioning

confidence: 99%

“…Gadd (1995) showed that calcium ions play an important role in the regulation of the apical mycelia growth as well as in the formation of hyphal branches, corroborating the positive effects promoted by this micronutrient. Lin and Yang (2006) obtained the highest mycelium yield of A. subrufescens in SmF with an initial pH of 6.06 and an incubation temperature of 27 C. Fan et al (2007) observed that a pH of 6.1 and a temperature of 30 C were the best setting points for increases in exopolysaccharide production. Other results show maximal biomass yield and exopolysaccharide production to happen at pH 5.6 and 6.9, with incubation temperatures of 24.6 and 20 C, respectively (Hamedi et al 2007).…”

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confidence: 99%

Fungal Cultivation and Production of Polysaccharides

Camelini¹,

Rossi²,

Cardozo³

et al. 2014

Polysaccharides

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Many species of higher basidiomycetes have traditionally been used because of their medicinal properties. The positive effects associated to the consumption of those fungi have been mainly attributed to cell wall polysaccharides, which have important structural roles and are present throughout the entire life cycles of fungi. One of the most consumed and studied species native of the Americas is Agaricus subrufescens, a mushroom prescribed in different countries for prophylaxis and noninvasive treatment of numerous health-related disorders. Prior to the process of extraction, purification, and application of these polysaccharides, one needs to be concerned with the preservation of the specimen and production of fungal biomass. Even though basidiomata (syn. fruiting bodies, mushrooms) generally yield larger volumes of biomass when compared to the mycelium, cultivation of mycelium allows a more efficient control of the process and, therefore, is the method of choice of polysaccharide production. Mycelial biomass can be produced by solid-state fermentation (SSF) or submersed fermentation (SmF). Further separation and concentration of bioactive polysaccharides can be done by means of porous membranes, such as tangential flow nanofiltration.

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“…The mushroom Agaricus brasiliensis, also known as A. blazei or A. subrufescens (Wasser et al, 2002;Kerrigan, 2005;Dias et al, 2008), has received great interest since the end of the 20th century, and several papers were recently published highlighting its medicinal properties (Kawagishi et al, 1989;Mizuno et al, 1990aMizuno et al, ,b, 1995Ito et al, 1997;Kaneno et al, 2004;Mizuno & Kawakami, 2006;Fan et al, 2007;Firenzuoli et al, 2008).…”

Section: Medicinal Mushroom (Agaricus Brasiliensis)mentioning

confidence: 99%

Mushroom cultivation in Brazil: challenges and potential for growth

Dias

2010

Ciênc. agrotec.

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Mushroom cultivation is rapidly expanding in Brazil because Brazilians have discovered the medicinal and culinary value of mushrooms and their economic situation has improved. However, the horticultural technology for cultivating mushrooms under Brazilian conditions is lacking. For many years, the mushroom cultivation technology used in Brazil was adapted from developed countries whose materials and climate were different from those of Brazil. In order to exploit the Brazilian potential for mushroom cultivation it is essential to develop cultivation technology for family owned and operated rustic farms as well as for modern large scale industrial operations. Mushroom species cultivated in Brazil are discussed and some approaches for future research are suggested.Index terms: Mushroom compost, casing layer, mushroom fruiting, Agaricus, Pleurotus, Lentinula. RESUMOO cultivo de cogumelos está em franca expansão no Brasil, graças à descoberta de suas propriedades medicinais e culinárias pelo povo brasileiro e também em função da melhoria das condições econômicas. Entretanto, há ainda uma necessidade de desenvolvimento de uma tecnologia de cultivo apropriada para as condições brasileiras. Durante muitos anos, a tecnologia de cultivo de cogumelos utilizada no Brasil foi uma adaptação daquela utilizada nos países desenvolvidos, cujas condições climáticas e disponibilidade de matéria-prima são diferentes do Brasil. Portanto, para que se possa desenvolver todo o potencial brasileiro para o cultivo de cogumelos, é essencial o desenvolvimento de tecnologias de cultivo mais apropriadas para a agricultura familiar, mas também é importante o desenvolvimento tecnológico voltado para o cultivo de cogumelos em escala industrial. As principais espécies de cogumelos cultivados no Brasil são discutidas neste trabalho, além da indicação das principais necessidades de pesquisa para o futuro. Termos para indexação:Composto de cultivo, camada de cobertura, indução da frutificação, Agaricus, Pleurotus, Lentinula.

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Effect of nutritional and environmental conditions on the production of exo-polysaccharide of Agaricus brasiliensis by submerged fermentation and its antitumor activity

Cited by 61 publications

References 10 publications

Bioactive properties of the medicinal mushroom Leucopaxillus giganteus mycelium obtained in the presence of different nitrogen sources

Bioactive properties of the medicinal mushroom Leucopaxillus giganteus mycelium obtained in the presence of different nitrogen sources

Fungal Cultivation and Production of Polysaccharides

Mushroom cultivation in Brazil: challenges and potential for growth

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