“…37 In addition, a cytokine shift to Th1-dominant patterns was observed in vitro in peripheral blood mononuclear cells isolated from Tanzanian children who were zinc deficient. 38 Propagation of immune responses such as immune cell proliferation, cytokine and antibody production, and tissue repair all require constant utilization of essential amino acids, which paralleled with the observed negative correlations between IL-2 levels and several AAs (valine, isoleucine, leucine, lysine, phenylalanine, and tyrosine). However, how MFGM consumption would modulate balance in the immune system needs further investigation.…”
This study builds on a previous study by this group in which 6–11-month-old Peruvian infants who were fed bovine milk fat globule membrane (MFGM) containing complementary food had significantly fewer episodes of infection-related bloody diarrhea relative to those consuming a control food (skim milk powder). Micronutrient deficiencies including zinc deficiency were prevalent in this study population. To understand the mechanism behind the health benefits of consuming MFGM, the serum metabolome and cytokine levels, as markers for systemic immune responses, were evaluated using
1
H nuclear magnetic resonance-based metabolomics and a multiplex system, respectively. Combined with data on micronutrient status and anthropometry, a comparative analysis was performed. Supplementation with MFGM tended to improve micronutrient status, energy metabolism, and growth reflected as increased levels of circulating amino acids and weight gain, particularly in female infants compared to controls. Decreased levels of the microbial choline metabolite trimethylamine-
N
-oxide in the MFGM-supplemented group (both male and female infants) suggest a functional perturbation in the intestinal microbiota. A cytokine shift toward a less T helper type 1 response was observed in those receiving the MFGM supplement, which was mainly attributed to decreases in interleukin-2 levels. Our findings suggest that consumption of MFGM with complementary food may reverse the metabolic abnormalities found in marginally nourished infants, thereby improving metabolic regulation, which may lead to enhanced immunity.
“…37 In addition, a cytokine shift to Th1-dominant patterns was observed in vitro in peripheral blood mononuclear cells isolated from Tanzanian children who were zinc deficient. 38 Propagation of immune responses such as immune cell proliferation, cytokine and antibody production, and tissue repair all require constant utilization of essential amino acids, which paralleled with the observed negative correlations between IL-2 levels and several AAs (valine, isoleucine, leucine, lysine, phenylalanine, and tyrosine). However, how MFGM consumption would modulate balance in the immune system needs further investigation.…”
This study builds on a previous study by this group in which 6–11-month-old Peruvian infants who were fed bovine milk fat globule membrane (MFGM) containing complementary food had significantly fewer episodes of infection-related bloody diarrhea relative to those consuming a control food (skim milk powder). Micronutrient deficiencies including zinc deficiency were prevalent in this study population. To understand the mechanism behind the health benefits of consuming MFGM, the serum metabolome and cytokine levels, as markers for systemic immune responses, were evaluated using
1
H nuclear magnetic resonance-based metabolomics and a multiplex system, respectively. Combined with data on micronutrient status and anthropometry, a comparative analysis was performed. Supplementation with MFGM tended to improve micronutrient status, energy metabolism, and growth reflected as increased levels of circulating amino acids and weight gain, particularly in female infants compared to controls. Decreased levels of the microbial choline metabolite trimethylamine-
N
-oxide in the MFGM-supplemented group (both male and female infants) suggest a functional perturbation in the intestinal microbiota. A cytokine shift toward a less T helper type 1 response was observed in those receiving the MFGM supplement, which was mainly attributed to decreases in interleukin-2 levels. Our findings suggest that consumption of MFGM with complementary food may reverse the metabolic abnormalities found in marginally nourished infants, thereby improving metabolic regulation, which may lead to enhanced immunity.
“…Consequently, it raises a worry that probably higher organisms have fewer chances for successful life in presence of lower organisms. Several efforts in research including experimental, clinical and immunological potential impact of improved nutrition to specific infections have been in place [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69]. Despite these efforts, however, vaccine and drug developments have been made difficult by the tricky survival strategies by pathogens making improvement in health focusing in nutrition not as good as might be if the pathogens were not that clever.…”
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