Effect of Number of Lymph Nodes Sampled on Outcome in Patients With Stage I Non–Small-Cell Lung Cancer

Gajra, Ajeet; Newman, Nancy; Gamble, Gary P.; Kohman, Leslie J.; Graziano, Stephen L.

doi:10.1200/jco.2003.07.010

Cited by 261 publications

(196 citation statements)

References 17 publications

Supporting

Mentioning

181

Contrasting

Unclassified

Order By: Relevance

“…For the removal of mediastinal lymph nodes, many investigators insist on the importance of systematic nodal dissection (SND) for accurate staging (4)(5)(6)(7)(8)(9)(10).…”

Section: Effect Of Mediastinal Lymph Nodes Sampling In Patients With mentioning

confidence: 99%

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

et al. 2008

View full text Add to dashboard Cite

:Objective : Systematic nodal dissection has been recommended for patients with resectable non-small cell lung cancer because of its staging accuracy. However, in patients with clinical stage I non-small cell lung cancer whether systematic nodal dissection provides more benefits than mediastinal lymph node sampling or not is controversial. In this retrospective study, we evaluated the effect of mediastinal lymph node sampling in patients with clinical stage I NSCLC. Methods : One hundred and nineteen consecutive patients with clinical stage I NSCLC, who underwent curative operation between January 1994 and December 2000, were retrospectively reviewed (dissection group = 58 : sampling group= 61). Systematic nodal dissection was defined as complete removal of mediastinal lymph node, and mediastinal lymph node sampling was defined as removal of lymph node levels 3, 4, and 7 for right-sided tumors and levels 5, 6, and 7 for left-sided tumors. Results : The total number of removed mediastinal lymph nodes in patients who underwent systematic nodal dissection was 22.1 9.7, which was significantly higher than that in patients who underwent mediastinal lymph node sampling of 11.4 7.0 (p 0.001). Postoperatively N2 disease was detected in 8 patients (13.8% %) in the dissection group and 7 (11.5% %) in the sampling group. After the median follow up of 79 months, the cancer specific survival rate at 5 year was 78.0% % in the dissection group and 76.2% % in the sampling group (p = 0.60). Conclusions : Mediastinal lymph node sampling showed the similar effect to systematic nodal dissection in patients with clinical stage I non-small cell lung cancer. J. Med. Invest. 55 : 37-43, February, 2008

show abstract

“…For the removal of mediastinal lymph nodes, many investigators insist on the importance of systematic nodal dissection (SND) for accurate staging (4)(5)(6)(7)(8)(9)(10).…”

Section: Effect Of Mediastinal Lymph Nodes Sampling In Patients With mentioning

confidence: 99%

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Among all the lung cancer-therapeutic methods, surgery plays a pivotal role, especially in the early-stage nonsmall cell lung cancer (NSCLC). Nowadays, the standard surgical treatment of early-stage NSCLC is lobectomy with systematic lymph node dissection (LND) as recommended by the guidelines (3,4), which capable of providing accurate staging (5,6), detecting occult metastasis (7) and improving survival (5,8,9). However, randomized trials have not demonstrated that LND has more survival benefit than sampling (7,10).…”

Section: Introductionmentioning

confidence: 99%

Selective lymph node dissection in early-stage non-small cell lung cancer

Han

Chen

2017

J. Thorac. Dis.

View full text Add to dashboard Cite

Lymph node dissection is a vital part of surgical treatment in early-stage non-small cell lung cancer (NSCLC). Removal of metastatic lymph nodes while preservation of intact lymph nodes are equally important. For hospitalized early-stage patients with limited lymph node metastasis, the operation treatment should be made according to some rules such as lobe-specific lymph node drainage pattern. In order to prevent unnecessary surgical trauma in early-stage patients, a minimally invasive approach with selective lymph node excision is preferred for more clinical benefits. This review summarizes the existing findings on lobe-specific lymph node drainage pattern and we hope to provide guidance for selective lymph node dissection (SLND). Furthermore, we include information on histologic views, a tumor marker and protocols of SLND, with hope to inspire creative research and clinical trials in this field.

show abstract

“…This figure seems to be superior to the absolute number of metastatic lymph nodes in predicting the prognosis and to be useful in reducing stage migration in types of solid cancers such as cancers of the stomach [8][9][10], breast [11], bladder [12], pancreas [13], and lung [14].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Impact of the Metastatic Lymph Node Ratio on Survival in Gastric Cancer

Attaallah

Uprak

Günal

et al. 2016

Indian J Surg Oncol

View full text Add to dashboard Cite

Research on the prognostic value of lymph node ratio (LNR) in gastric cancer (GC) remains limited and controversial results were obtained. In this study, we aimed to evaluate whether LNR was an independent prognostic factor for gastric carcinoma. A retrospective review of a database of gastric cancer patients was performed to determine the effect of the LNR on the overall survival (OS) and the disease-free survival (DFS). Of the total 135 patients with gastric cancer who underwent resection between March 2012 and December 2013, 44 patients with non metastatic gastric cancer were eligible for analysis. Survival curves were estimated using the Kaplan-Meier method. Cox regression analyses, after adjustments for potential confounders, were used to evaluate the relationship between the LNR and survival. According to the cutoff point 0.37 (37 %), the one-year OS rate for LNR ≤ 37 % was significantly better than that for LNR > 37 % (91.3 % and 61.9 %, respectively, P = 0.02). The one-year DFS for LNR ≤ 37 % was significantly better than that for LNR > 37 % (91.3 % and 66.7 %, respectively, P = 0.027). In stratified and multivariate analyses adjusted for age, gender, histology and tumor status, a higher LNR was associated with high pN stage and so associated with worse OS and DFS. Thus, the LNR 37 % as a cutoff point was found not to be an independent factor for predicting the one-year OS or DFS in patients with non-metastatic GC. The LNR is a prognostic factor in GC. However, no single cut-off value was determined as an independent prognostic factor.

show abstract

Effect of Number of Lymph Nodes Sampled on Outcome in Patients With Stage I Non–Small-Cell Lung Cancer

Cited by 261 publications

References 17 publications

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

Effect of mediastinal lymph nodes sampling in patients with clinical stage I non-small cell lung cancer

Selective lymph node dissection in early-stage non-small cell lung cancer

Prognostic Impact of the Metastatic Lymph Node Ratio on Survival in Gastric Cancer

Contact Info

Product

Resources

About