Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort

Robinson, Cleo; Alfonso, Helman; SeungSeok, Woo; Olsen, Nola; Musk, A.W.; Robinson, B. W.; Nowak, Anna K.; Lake, Richard

doi:10.1016/j.lungcan.2014.08.005

Cited by 12 publications

(11 citation statements)

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“…A successful prevention agent would be particularly useful for the millions of people worldwide who are living with a known asbestos exposure. Vitamins A, E, D and selenium and anti-inflammatory drugs were not found to have a benefit in the MexTAg model, despite a history of preventative activity and in vitro evidence for use against mesothelioma, findings that were confirmed for vitamin A and NSAIDs in a human cohort of asbestos-exposed workers from the Wittenoom crocidolite asbestos mines [70][71][72].…”

Section: • • Asbestos-induced Transgenic Modelsmentioning

confidence: 87%

Mouse Models of Mesothelioma: Strengths, Limitations and Clinical Translation

et al. 2014

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These authors contributed equally SUMMARY Mouse models of cancer are invaluable for obtaining detailed knowledge about tumor development and for screening therapeutic and preventive approaches. Mesothelioma is an unusual cancer because the same carcinogen, asbestos, causes a similar disease in both humans and animals. Unlike most other cancers, murine mesothelioma can therefore be regarded as a disease homolog, rather than a model as such. However, because asbestos-induced cancer has low penetrance and a long lag time, most translational studies have utilized more efficient models such as tumor transplantation. In consequence, many promising results have not translated into positive findings in patients. Here, we describe the widely used murine mesothelioma models and critically discuss their relative advantages and disadvantages. We emphasize the use of the appropriate model for the specific research question and the need to use multiple models in order to obtain robust and translatable data.

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Section: • • Asbestos-induced Transgenic Modelsmentioning

confidence: 87%

Mouse Models of Mesothelioma: Strengths, Limitations and Clinical Translation

et al. 2014

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“…However, previous studies using plausible chemoprophylactic agents have been disappointing. In a transgenic mouse model of peritoneal mesothelioma, driven by SV40 Tag and induced by asbestos injection, anti-inflammatories (aspirin and cyclo-oxygenase-2 (COX-2) inhibitors) and anti-oxidants (Selenium, Vitamin A or Vitamin E) did not demonstrate useful chemoprophylactic effects [111]. In a xenograft (immunodeficient) peritoneal MPM mouse model, aspirin has recently been reported to suppress HMGB-1 levels and tumour growth [112], which may be relevant since HMGB1 is implicated in MPM pathogenesis and is detectable in blood at presentation in many patients [28].…”

Section: Chemoprophylaxismentioning

confidence: 99%

Progress and challenges in Mesothelioma: From bench to bedside

Blyth

Murphy

2018

Respiratory Medicine

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Malignant Pleural Mesothelioma (MPM) is currently an incurable cancer with a typical survival of 1 year from the time of diagnosis. The recent genomic and transcriptomic characterization of MPM presents new opportunities and challenges for MPM researchers. Recent advances in clinical and laboratory diagnostics, and proposals for an updated, data-driven, staging system, also present new challenges for clinicians and hospital services involved in MPM care. The aim of this review is first to introduce the reader to the topic of MPM, a disease that is causally linked to prior, typically occupational, exposure to asbestos fibres. Secondly, we will discuss MPM from the clinical and laboratory perspectives, including reviews of current and evolving therapies and our present understanding of the molecular basis of the disease. Finally, we will attempt to identify critical knowledge gaps that currently prevent more effective treatment, including the challenges involved in early detection and chemoprophylaxis.

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“…In this regard, however, aspirin has not proven effective at preventing other asbestosrelated malignancies in an animal model and in a human cohort. (5) In conclusion, the Choi et al study represents an innovation in the fields of hepatology and oncology and identifies a possible preventive role of aspirin in the development of CC. The results of this retrospec-tive study need validation through prospective studies on selected high-risk populations.…”

Section: To the Editormentioning

confidence: 91%