Effect of noxious stimulation on sympathetic vasoconstrictor outflow to human muscles.

Nordin, Magnus; Fagius, Jan

doi:10.1113/jphysiol.1995.sp021101

Cited by 63 publications

(52 citation statements)

References 30 publications

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“…Concerning the idea of synchrony and neuroeffector transmission, enhanced sympathetic synchrony (burst discharges) has been reported in humans under conditions of stress (Callister et al, 1992;Nordin and Fagius, 1995;Morgan et al, 1996;Katragadda et al, 1997), and it has been proposed that the bursts of sympathetic activity may have important consequences for neuroeffector transmission and therefore the end organ response (Sneddon and Burnstock, 1984;Sjöblom-Widfelt et al, 1990). We propose that synchrony may bring about widespread depolarization of electrotonically coupled smooth muscle in blood vessels via ATP released from sympathetic nerve endings (Morris and Gibbins, 1992).…”

Section: Functional Significance Of Synchronization Of Sympathetic Acmentioning

confidence: 89%

Sympathetic Neuronal Oscillators are Capable of Dynamic Synchronization

et al. 1999

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In this paper we show that the discharges of sympathetic neurons innervating an identified peripheral target are driven by multiple oscillators that undergo dynamic synchronization when an entraining force, central respiratory drive (CRD), is increased. Activity was recorded from postganglionic sympathetic neurons (PGNs) innervating the caudal ventral artery of the rat tail: (1) at the population level from the ventral collector nerve (VCN); and (2) from pairs of single PGNs recorded simultaneously using a focal recording technique. Autospectral analysis of VCN activity revealed a more prominent rhythmical component in the presence of CRD than in its absence, suggesting that (1) multiple oscillators drive the discharges of PGNs and (2) these oscillators can be entrained and therefore synchronized by CRD. This interpretation was supported by analysis of the firing behavior of PGN pairs. Autocorrelation and cross-correlation analysis showed that pairs were not synchronized in the absence of CRD but showed significant synchronization when CRD was enhanced. Time-evolving spectral analysis and raster plots demonstrated that the temporal stability of PGN-to-PGN and CRD-to-PGN interactions at a given level of CRD were also dynamic in nature, with stable constant phase relationships predominating as CRD was increased. This is the first reported example of dynamic synchronization in populations of single postganglionic sympathetic neurons, and we suggest that, as in sensory processing and motor control, temporal pattern coding may also be an important feature of neuronal discharges in sympathetic pathways.

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Section: Functional Significance Of Synchronization Of Sympathetic Acmentioning

confidence: 89%

Sympathetic Neuronal Oscillators are Capable of Dynamic Synchronization

et al. 1999

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“…Pressure applied to the supraorbital ridge, electrical stimulation of the supraorbital nerve, instillation of soap solution in the eye and immersion of the face in cold water all caused or tended to cause bradycardia and an increase in MSNA and blood pressure (Fagius and Sundlöf, 1986;Nordin and Fagius, 1995). Very simple manoeuvres like placing an ice-bag on the forehead or directing a stream of cold air (0-10 • C) towards the face also evoked similar hemodynamic adjustments (Hayward et al, 1976;Allen et al, 1992;LeBlanc and Mercier, 1992;Trouerbach et al, 1994;Walsh et al, 1995).…”

Section: Localized Cooling Of the Skinmentioning

confidence: 98%

“…The role of facial receptors in cardiovascular reflexes has also been investigated before (Fagius and Sundlöf, 1986;Nordin and Fagius, 1995). Various types of noxious stimuli to the trigeminal region resulted in a reflex pattern characterized by rises in MSNA and blood pressure and by bradycardia.…”

Section: Introductionmentioning

confidence: 99%

Effect of facial cooling and cold air inhalation on sympathetic nerve activity in men

Heindl¹,

Struck²,

Wellhöner³

et al. 2004

Respiratory Physiology & Neurobiology

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In nine healthy subjects, cold stimuli were administered to the forehead and hand, to the oral and nasal cavities via ice cubes and to the bronchial system via inhalation of cold air (−25 • C). Blood pressure, heart rate and muscle sympathetic nerve activity (MSNA) from the peroneal nerve were recorded. MSNA expressed as total activity increased during cold air inhalation, cooling of the forehead (P < 0.001, ANOVA), hand and mouth (P ≤ 0.05), paralleled by a rise in blood pressure during cold air inhalation and cooling of the forehead and hand (P < 0.01). Cooling of the forehead provoked a faster increase of MSNA expressed as total activity (P < 0.05) and higher levels of diastolic blood pressure (P = 0.05) compared with cooling of the hand. Bradycardia was observed only during cooling of the nasal cavity (P < 0.001) and the forehead (P < 0.05). It is concluded that cooling of the skin and mucous membranes of the tracheobronchial tract elicits sympathetically mediated hemodynamic adaptations, probably via stimulation of cold-sensitive afferents.

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“…Any pain activates the sympathetic nervous system with a release of norepinephrine, as has been demonstrated in the clinic and experimentally [50][51][52]. There is no sufficient evidence showing that the onset of hypertension triggers the crisis of cardiac pain.…”

Section: Acute Coronary Ischemiamentioning

confidence: 99%

Hypertensive Emergencies: a New Clinical Approach

Lagi

Cencetti

2014

J Hypertens

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The expression 'hypertensive urgencies' includes many diseases. The unifying features of these diseases are a high level of arterial pressure and acute distress of one or more organs. The aim of the review was to define the idea of the 'acute hypertension' as a new concept, different from 'chronic hypertension'. Acute hypertension might be related to 'organ damage' because it is the cause, the consequence or an effect of the acute stress. We compounded a narrative review which has included analyses of 373 articles. The structure of the search strategy included a literature search of PubMed, MEDLINE, Cochrane Library and Google Scholar databases. We applied the following inclusion criteria: prospective double-blind randomised controlled trials, experimental animal work studies, case-control studies and recruiting patients representative of the general sick population. In this review, the diseases included in the term 'hypertensive emergencies' share 'acute' hypertension. This is a new idea that emphasises the suddenly increased arterial pressure, irrespective of the initial arterial pressure and independent of the goals of hypertension control. The 'hypertensive emergencies' have been grouped together in three subsets: (1) diseases that result from acute hypertension that is caused by faulty regulation of the peripheral circulation (acute primary hypertension), (2) diseases that produce hypertension (acute secondary hypertension) and 3) diseases that have hypertension as an effect of the acute stress caused by the principle disease (acute associated hypertension). This review highlights a novel idea: acute hypertension is a common sign of different diseases characterised by the sudden surge of arterial pressure, so overwhelming the difference between hypertensive emergencies and urgencies. The judgment of acute hypertension is independent of the initial arterial pressure, normotension or hypertension and is linked with the transient failure of the baroreflex. Hypertensive emergencies are grouped together because all of these diseases require prompt therapy to prevent the negative outcomes of acute hypertension

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Effect of noxious stimulation on sympathetic vasoconstrictor outflow to human muscles.

Cited by 63 publications

References 30 publications

Sympathetic Neuronal Oscillators are Capable of Dynamic Synchronization

Sympathetic Neuronal Oscillators are Capable of Dynamic Synchronization

Effect of facial cooling and cold air inhalation on sympathetic nerve activity in men

Hypertensive Emergencies: a New Clinical Approach

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