Effect of norepinephrine and vasopressin on carotid sinus baroreceptor activity in the anesthetized rabbit

Holmes, Allan; Ledsome, J. R.

doi:10.1007/bf01951973

Cited by 7 publications

(3 citation statements)

References 9 publications

(2 reference statements)

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“…This response may be related to a direct effect of AVP on carotid arterial vessels (43). In anesthetized rabbits, increases in single fiber and whole nerve afferent traffic in response to carotid sinus pressure changes are augmented by AVP infusion (49).…”

Section: Methodsmentioning

confidence: 98%

Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man.

Ebert¹,

Cowley²,

Skelton³

1986

J. Clin. Invest.

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We examined the effects of physiologic infusions of arginine vasopressin (AVP) on cardiovascular hemodynamics and on reflex responses initiated by decreasing cardiopulmonary baroreceptor stimulation (with lower body negative pressure) in 10 healthy, captopril-pretreated young men (19-27 yr). Their responses were compared with those of four volunteers given isosmotic infusion. Heart rate, stroke volume, blood pressure, and forearm blood flow were measured by electrocardiography, impedance cardiography, radial artery cannulation, and strain gauge plethysmography. Two 55-min infusions of AVP at rates of 0.15 and 0.40 ng/kg per min increased average plasma concentrations from control levels of 5 pg/ml to 18 and 36 pg/ml, respectively. These infusions resulted in progressive reductions of heart rate and cardiac output and increases of forearm and total peripheral resistance. Blood pressure increases were significant only during the larger AVP infusion rate. Lower body negative pressure provoked reflex increases of total peripheral resistance. These increases were enhanced 60% during AVP infusion compared with increases during control (pre-AVP). Baseline measurements and reflex responses were unchanged by isosmotic infusions. These results demonstrate that AVP has profound effects on cardiovascular function and augments cardiopulmonary baroreflex-mediated increases of peripheral resistance in man.

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Section: Methodsmentioning

confidence: 98%

Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man.

Ebert¹,

Cowley²,

Skelton³

1986

J. Clin. Invest.

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“…Interestingly, in four of the experiments there was a short period of a reduced PNA, which started simultaneously with the NE-induced increase of the perfusion pressure (aPP). Activation of arterial baroreceptors by the elevated aPP or directly by NE ( Holmes and Ledsome, 1984 ), would negatively modulate the network in the VRC ( Simms et al, 2007 ; Barnett et al, 2021 ). After adaptation of the baroreflex, the neuron-mediated stimulation of the network by NE will become dominant ( Zanella et al, 2014 ; Tacke et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Fiber optical imaging of astroglial calcium signaling in the respiratory network in the working heart brainstem preparation

Tacke,

Bischoff,

Harb

et al. 2023

Front. Physiol.

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The neuronal activity in the respiratory network strongly depends on a variety of different neuromodulators. Given the essential role of astrocytes in stabilizing respiratory network activity generated by neurons in the preBötzinger complex (preBötC), our aim was to investigate astrocytic calcium signaling in the working heart brainstem preparation using fiber-optical imaging. By using transgenic mice that express GCaMP6s specifically in astrocytes, we successfully recorded astrocytic calcium signals in response to norepinephrine from individual astrocytes.

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“…Landgren, Neil & Zotterman (1952) reported that local injection of pitressin into a connective tissue sac around the carotid sinus region of cat increased the firing of two baroreceptor units (one with 'small' and one with 'large' amplitude spikes). Holmes & Ledsome (1984) showed in anaesthetized rabbits a very small increase in activity of whole carotid sinus nerves and inconsistent results in single fibres when vasopressin was given in the isolated sinus.…”

Section: Evidence That Vasopressin Facilitates the Baroreflexmentioning

confidence: 99%

Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals.

Abboud¹,

Aylward²,

Floras³

et al. 1986

The Journal of Physiology

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SUMMARY1. Vasopressin facilitates the baroreflex control ofthe circulation. The peptide may act at several sites to augment the baroreflex. In this study we examined the effect of vasopressin on aortic baroreceptors in anaesthetized rabbits and on left ventricular mechanoreceptors in anaesthetized cats.2 Vasopressin (16 mu./kg. min) did not change resting nerve discharge in single fibres from aortic baroreceptors.3. Vasopressin (16 mu./kg. min) significantly enhanced the response of single aortic nerve fibre discharge to elevation in arterial pressure. The slope relating nerve activity to mean arterial pressure increased from 0-24 + 0'05 (mean + S.E. of mean) to 0'50+0-16 impulses/cardiac cycle . mmHg (P < 0-05) in ten aortic medullated fibres and from 0-06 + 0 03 to 0-18 + 0-04 impulses/cardiac cycle . mmHg (P < 0-05) in three non-medullated fibres.4. Vasopressin (16 mu./kg. min) did not change resting nerve discharge in single fibres from left ventricular mechanoreceptors.5. Vasopressin (16 mu./kg. min) significantly enhanced the response ofsingle nerve fibre discharge from left ventricular mechanoreceptors in response to elevation of left ventricular end-diastolic pressure. The slope relating nerve activity to left ventricular end-diastolic pressure increased from 0-24 + 0-07 to 0-32 + 0-07 impulses/cardiac cycle. mmHg (P < 005) in six medullated fibres and from 0 10 +0-01 to 0 15 + 0-02 impulses/cardiac cycle . mmHg (P < 0-05) in four non-medullated fibres.6. These data show that vasopressin sensitizes high and low pressure baroreceptors and suggest a mechanism by which vasopressin may facilitate the baroreflex control of the circulation.

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Effect of norepinephrine and vasopressin on carotid sinus baroreceptor activity in the anesthetized rabbit

Cited by 7 publications

References 9 publications

Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man.

Vasopressin reduces cardiac function and augments cardiopulmonary baroreflex resistance increases in man.

Fiber optical imaging of astroglial calcium signaling in the respiratory network in the working heart brainstem preparation

Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals.

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